{"id":"https://openalex.org/W2073608176","doi":"https://doi.org/10.1038/sj.emboj.7601568","title":"Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant\u2010negative, or hypomorphic alleles","display_name":"Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant\u2010negative, or hypomorphic alleles","publication_year":2007,"publication_date":"2007-02-08","ids":{"openalex":"https://openalex.org/W2073608176","doi":"https://doi.org/10.1038/sj.emboj.7601568","mag":"2073608176","pmid":"https://pubmed.ncbi.nlm.nih.gov/17290219","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1852839"},"language":"en","primary_location":{"id":"doi:10.1038/sj.emboj.7601568","doi":"https://doi.org/10.1038/sj.emboj.7601568","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.emboj.7601568","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.emboj.7601568","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.emboj.7601568","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003502388","display_name":"Christina Matheny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina J Matheny","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA","Department of Biochemistry, Dartmouth Medical School Hanover NH USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School Hanover NH USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003611896","display_name":"Maren E. Speck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maren E Speck","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School Hanover NH USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School Hanover NH USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049120212","display_name":"Patrick R. Cushing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick R Cushing","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School Hanover NH USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School Hanover NH USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003477437","display_name":"Yunpeng Zhou","orcid":"https://orcid.org/0000-0002-5550-8974","observed_orcids":["https://orcid.org/0000-0002-5550-8974"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunpeng Zhou","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069352045","display_name":"Takeshi Corpora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takeshi Corpora","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086553722","display_name":"Michael C. Regan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Regan","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041057085","display_name":"Miki N. Newman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miki Newman","raw_affiliation_strings":["Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063935480","display_name":"Liya Roudaia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liya Roudaia","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School Hanover NH USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School Hanover NH USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109107301","display_name":"Caroline L. Speck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline L Speck","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School Hanover NH USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School Hanover NH USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110899203","display_name":"Ting-Lei Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting\u2010Lei Gu","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School Hanover NH USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School Hanover NH USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111674942","display_name":"Stephen M. Griffey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen M Griffey","raw_affiliation_strings":["Comparative Pathology Laboratory, School of Veterinary Medicine, University of California Davis CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comparative Pathology Laboratory, School of Veterinary Medicine, University of California Davis CA USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058775784","display_name":"John Hackett Bushweller","orcid":"https://orcid.org/0000-0002-5386-1758","observed_orcids":["https://orcid.org/0000-0002-5386-1758"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John H Bushweller","raw_affiliation_strings":["Department of Chemistry, University of Virginia Charlottesville VA USA","Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia Charlottesville VA USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Molecular Physiology and Biological Physics, University of Virginia Charlottesville VA USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017920497","display_name":"Nancy A. Speck","orcid":"https://orcid.org/0000-0002-1893-582X","observed_orcids":["https://orcid.org/0000-0002-1893-582X"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nancy A Speck","raw_affiliation_strings":["Department of Biochemistry, Dartmouth Medical School Hanover NH USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dartmouth Medical School Hanover NH USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017920497","https://openalex.org/A5058775784"],"corresponding_institution_ids":["https://openalex.org/I107672454","https://openalex.org/I51556381"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":4.7681,"has_fulltext":true,"cited_by_count":119,"citation_normalized_percentile":{"value":0.95190134,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"26","issue":"4","first_page":"1163","last_page":"1175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":1.0},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cleidocranial-dysplasia","display_name":"cleidocranial dysplasia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hypomorphic-allele","display_name":"hypomorphic allele","score":0.7350000143051147},{"id":"https://openalex.org/keywords/dominant-negative-allele","display_name":"dominant-negative allele","score":0.8529999852180481},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.9380000233650208},{"id":"https://openalex.org/keywords/runt-domain","display_name":"Runt domain","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.8690000176429749},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.8920000195503235},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9452388882637024},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7069453001022339},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6914523839950562},{"id":"https://openalex.org/C2778193527","wikidata":"https://www.wikidata.org/wiki/Q15320451","display_name":"RUNX1","level":4,"score":0.5371615886688232},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5133765935897827},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4738086760044098},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2668270170688629},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.23189863562583923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06501224637031555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002973","descriptor_name":"Cleidocranial Dysplasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006402","descriptor_name":"Hematologic Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050658","descriptor_name":"Core Binding Factor beta Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.emboj.7601568","doi":"https://doi.org/10.1038/sj.emboj.7601568","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.emboj.7601568","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.emboj.7601568","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1852839","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1852839","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:17290219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17290219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1038/sj.emboj.7601568","doi":"https://doi.org/10.1038/sj.emboj.7601568","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.emboj.7601568","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.emboj.7601568","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4963384019","display_name":"MOUSE MODELS FOR FAMILIAL PLATELET DISORDER","funder_award_id":"R01CA089419","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G518495827","display_name":null,"funder_award_id":"CA23108","funder_id":"https://openalex.org/F4320332817","funder_display_name":"Norris Cotton Cancer Center"},{"id":"https://openalex.org/G6981840230","display_name":"Molecular and Cellular Biology at Dartmouth","funder_award_id":"T32GM008704","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000859653","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA023108","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332817","display_name":"Norris Cotton Cancer Center","ror":"https://ror.org/00d1dhh09"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073608176.pdf","grobid_xml":"https://content.openalex.org/works/W2073608176.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1541919983","https://openalex.org/W1564956131","https://openalex.org/W1600695244","https://openalex.org/W1739103212","https://openalex.org/W1890692607","https://openalex.org/W1965099673","https://openalex.org/W1965825612","https://openalex.org/W1972130478","https://openalex.org/W1974362197","https://openalex.org/W1982721874","https://openalex.org/W1986389204","https://openalex.org/W1991766825","https://openalex.org/W1996350539","https://openalex.org/W1996899753","https://openalex.org/W1998543370","https://openalex.org/W2006048313","https://openalex.org/W2013714561","https://openalex.org/W2019732553","https://openalex.org/W2023197851","https://openalex.org/W2030587990","https://openalex.org/W2033256744","https://openalex.org/W2035726898","https://openalex.org/W2036287488","https://openalex.org/W2038401448","https://openalex.org/W2039210066","https://openalex.org/W2039655485","https://openalex.org/W2044923556","https://openalex.org/W2046907229","https://openalex.org/W2047596219","https://openalex.org/W2079852484","https://openalex.org/W2080607444","https://openalex.org/W2085033687","https://openalex.org/W2086083531","https://openalex.org/W2093059615","https://openalex.org/W2099405453","https://openalex.org/W2102601404","https://openalex.org/W2103012849","https://openalex.org/W2105723130","https://openalex.org/W2115055038","https://openalex.org/W2132749685","https://openalex.org/W2134305063","https://openalex.org/W2140596923","https://openalex.org/W2148033929","https://openalex.org/W2148247618","https://openalex.org/W2149787089","https://openalex.org/W2156828054","https://openalex.org/W2160494819","https://openalex.org/W2168497623","https://openalex.org/W2424613988","https://openalex.org/W2610334482"],"related_works":["https://openalex.org/W2523605647","https://openalex.org/W2149787089","https://openalex.org/W2981286071","https://openalex.org/W1981770612","https://openalex.org/W2556599590","https://openalex.org/W2271634026","https://openalex.org/W2559536183","https://openalex.org/W2593759860","https://openalex.org/W2016313505","https://openalex.org/W2080607444"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}