{"id":"https://openalex.org/W2073597798","doi":"https://doi.org/10.1113/jphysiol.1993.sp019934","title":"Microheterogeneity of subsarcolemmal sodium gradients. Electron probe microanalysis in guinea\u2010pig ventricular myocytes.","display_name":"Microheterogeneity of subsarcolemmal sodium gradients. Electron probe microanalysis in guinea\u2010pig ventricular myocytes.","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W2073597798","doi":"https://doi.org/10.1113/jphysiol.1993.sp019934","mag":"2073597798","pmid":"https://pubmed.ncbi.nlm.nih.gov/8145148","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1160474"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1993.sp019934","doi":"https://doi.org/10.1113/jphysiol.1993.sp019934","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1993.sp019934","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1160474","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113492879","display_name":"Maria Fiora Wendt-Gallitelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M F Wendt\u2010Gallitelli","raw_affiliation_strings":["Department of Physiology, University of T\u00fcbingen, Germany","Department of Physiology, University of Tubingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Physiology, University of Tubingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034688826","display_name":"Tilman Voigt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Voigt","raw_affiliation_strings":["Department of Physiology, University of Tubingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tubingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020273470","display_name":"G Isenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Isenberg","raw_affiliation_strings":["Department of Physiology, University of Tubingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tubingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I8087733"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":4.0613,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.94163603,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"472","issue":"1","first_page":"33","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.8790000081062317},{"id":"https://openalex.org/keywords/sodium-calcium-exchange","display_name":"sodium-calcium exchange","score":0.7599999904632568},{"id":"https://openalex.org/keywords/intracellular-sodium-concentration","display_name":"intracellular sodium concentration","score":0.8109999895095825},{"id":"https://openalex.org/keywords/sarcolemma","display_name":"sarcolemma","score":0.6970000267028809},{"id":"https://openalex.org/keywords/calcium-efflux","display_name":"calcium efflux","score":0.5699999928474426},{"id":"https://openalex.org/keywords/guinea-pig-heart","display_name":"guinea pig heart","score":0.6169999837875366},{"id":"https://openalex.org/keywords/electron-probe-microanalysis","display_name":"electron probe microanalysis","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C199096232","wikidata":"https://www.wikidata.org/wiki/Q1545001","display_name":"Sarcolemma","level":3,"score":0.8021876811981201},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6834403276443481},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.607822060585022},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5313670635223389},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4444962441921234},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4392701983451843},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.4137803912162781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21820518374443054},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1734028458595276},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.14040285348892212},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13813596963882446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07504025101661682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06749787926673889},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004577","descriptor_name":"Electron Probe Microanalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012508","descriptor_name":"Sarcolemma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1993.sp019934","doi":"https://doi.org/10.1113/jphysiol.1993.sp019934","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1993.sp019934","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1160474","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1160474","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:8145148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8145148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1160474","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1160474","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1964233954","https://openalex.org/W1971431736","https://openalex.org/W1975663695","https://openalex.org/W1995994865","https://openalex.org/W2004403903","https://openalex.org/W2011920501","https://openalex.org/W2047620575","https://openalex.org/W2065490409","https://openalex.org/W2068595881","https://openalex.org/W2080317393","https://openalex.org/W2092377076","https://openalex.org/W2103825195","https://openalex.org/W2116275634","https://openalex.org/W2285387263"],"related_works":["https://openalex.org/W2909040787","https://openalex.org/W2069564726","https://openalex.org/W3147062237","https://openalex.org/W2156381819","https://openalex.org/W2064058560","https://openalex.org/W2515888895","https://openalex.org/W1995278670","https://openalex.org/W2102552083","https://openalex.org/W2013364226","https://openalex.org/W1981352541"],"abstract_inverted_index":{"1.":[0],"The":[1,253],"effect":[2],"of":[3,23,121,167,171,233,304],"stimulation":[4,185],"on":[5],"possible":[6],"subsarcolemmal":[7],"sodium":[8,77,85,148,258],"accumulation":[9],"was":[10,132,186,213,248],"studied":[11],"in":[12,161],"ventricular":[13],"myocytes":[14],"(2":[15],"mM":[16,136,198,298,306],"[Ca2+]o,":[17],"36":[18],"degrees":[19],"C).":[20],"By":[21],"trains":[22],"eighteen":[24],"paired":[25],"voltage-clamp":[26],"pulses":[27],"(180":[28],"ms":[29,34,39,44],"to":[30,35,40,45,52,66,74,118,150,179,194,203,239],"0":[31],"mV,":[32,37,42],"20":[33,165],"-45":[36,46],"180":[38],"+50":[41,102],"620":[43],"mV)":[47],"unloaded":[48],"contractions":[49],"were":[50,72,280],"potentiated":[51,220],"an":[53],"optimum.":[54],"2.":[55],"Potentiation":[56,96,174],"reversibly":[57,97,175],"enlarged":[58],"and":[59,104,199,263,287,320],"prolonged":[60],"the":[61,82,99,119,139,168,172,237,240],"diastolic":[62],"tail":[63],"currents":[64],"due":[65],"Na(+)-Ca2+":[67],"exchange.":[68],"Eighteen":[69],"pulse":[70],"pairs":[71],"estimated":[73],"provide":[75],"a":[76,112,128,162,230],"influx":[78],"that":[79,143,257,313],"could":[80],"increment":[81],"total":[83],"intracellular":[84,147],"concentration":[86,149],"(sigma":[87],"Na(i))":[88],"by":[89,268,273],"no":[90],"more":[91,107],"than":[92,272],"0.5":[93],"mM.":[94,152,183,207,217,252,289],"3.":[95],"increased":[98,176],"current":[100],"at":[101,223,242,284,316,324],"mV":[103],"made":[105],"it":[106],"noisy.":[108],"Cell-attached":[109],"recordings":[110,141],"with":[111,134,229,282,296,302],"second":[113],"electrode":[114],"attributed":[115],"this":[116],"noise":[117],"activation":[120,323],"K+":[122],"(Na)":[123],"channels.":[124],"In":[125,208,219],"inside-out":[126],"patches,":[127],"comparable":[129],"channel":[130,322],"activity":[131],"obtained":[133],"40":[135,151,180],"sodium.":[137],"Hence,":[138],"cell-attached":[140],"suggest":[142],"potentiation":[144],"can":[145,328],"increase":[146],"4.":[153],"Electron":[154],"probe":[155],"microanalysis":[156],"(EPMA)":[157],"measured":[158],"sigma":[159,177,188,211,226,246,264,277,299,307,318,326],"Na":[160,227,247],"volume":[163],"within":[164,191,200],"nm":[166,235],"inner":[169],"side":[170],"sarcolemma.":[173],"Na20nm":[178,189,212,265,278,300,319,327],"+/-":[181,196,205,215,250],"7":[182],"When":[184],"terminated,":[187],"fell":[190,228],"8":[192,197],"s":[193],"37":[195],"3":[201,251],"min":[202],"19":[204],"6":[206],"unstimulated":[209],"cells":[210],"17":[214],"5":[216],"5.":[218],"cells,":[221],"shock-frozen":[222],"early":[224],"systole,":[225],"space":[231],"constant":[232],"28":[234],"from":[236],"sarcolemma":[238],"centre;":[241],"1":[243],"microns":[244],"distance":[245],"12":[249],"steep":[254],"gradient":[255],"suggests":[256,312],"does":[259],"not":[260],"freely":[261],"diffuse":[262],"is":[266],"controlled":[267],"transmembrane":[269],"fluxes":[270],"rather":[271],"cell":[274],"dialysis.":[275],"6.":[276],"data":[279],"distributed":[281],"peaks":[283],"5,":[285],"30":[286],"60":[288],"Quantitative":[290],"elemental":[291],"digital":[292],"imaging":[293],"demonstrated":[294],"patches":[295],"60-80":[297],"alternating":[301],"others":[303],"0-15":[305],"Na20nm.":[308],"This":[309],"'sodium":[310],"microheterogeneity'":[311],"Ca2+":[314],"efflux":[315],"low":[317],"K+(Na)":[321],"high":[325],"operate":[329],"simultaneously.":[330]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
