{"id":"https://openalex.org/W2073593530","doi":"https://doi.org/10.1016/s0960-894x(99)00010-4","title":"Nucleosides and nucleotides. 183. Synthesis of 4\u2032 \u03b1-branched thymidines as a new type of antiviral agent","display_name":"Nucleosides and nucleotides. 183. Synthesis of 4\u2032 \u03b1-branched thymidines as a new type of antiviral agent","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2073593530","doi":"https://doi.org/10.1016/s0960-894x(99)00010-4","mag":"2073593530","pmid":"https://pubmed.ncbi.nlm.nih.gov/10091689"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-894x(99)00010-4","doi":"https://doi.org/10.1016/s0960-894x(99)00010-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(99)00010-4","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040448285","display_name":"Isamu Sugimoto","orcid":"https://orcid.org/0000-0003-3786-8228","observed_orcids":["https://orcid.org/0000-0003-3786-8228"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isamu Sugimoto","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102670495","display_name":"Satoshi Shuto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Shuto","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105938901","display_name":"Shuichi Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Mori","raw_affiliation_strings":["Department of Bacteriology, Fukushima Medical College, Fukushima 960-1247, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Fukushima Medical College, Fukushima 960-1247, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112643049","display_name":"Shir\u00f4 Shigeta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiro Shigeta","raw_affiliation_strings":["Department of Bacteriology, Fukushima Medical College, Fukushima 960-1247, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Fukushima Medical College, Fukushima 960-1247, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111699102","display_name":"Akira Matsuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akira Matsuda","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111699102"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":4.6648,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.95064798,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"3","first_page":"385","last_page":"388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.08730000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.04699999839067459,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.7400000095367432},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.9240000247955322},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.972000002861023},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.893386721611023},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6898366212844849},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6865494251251221},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.6419185996055603},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.5059370398521423},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.40011078119277954},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35907045006752014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23412677645683289},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06413686275482178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0960-894x(99)00010-4","doi":"https://doi.org/10.1016/s0960-894x(99)00010-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(99)00010-4","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:10091689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10091689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1977911233","https://openalex.org/W1986632606","https://openalex.org/W2008186334","https://openalex.org/W2013618562","https://openalex.org/W2019614596","https://openalex.org/W2028731355","https://openalex.org/W2032039742","https://openalex.org/W2045636114","https://openalex.org/W2063825413","https://openalex.org/W2071921630","https://openalex.org/W2087914469","https://openalex.org/W2097288920","https://openalex.org/W2156488616"],"related_works":["https://openalex.org/W2952866801","https://openalex.org/W1993036141","https://openalex.org/W2072680017","https://openalex.org/W2868810458","https://openalex.org/W2951994200","https://openalex.org/W2952083640","https://openalex.org/W2081912295","https://openalex.org/W2066191837","https://openalex.org/W2845992353","https://openalex.org/W1537660037"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
