{"id":"https://openalex.org/W2073581978","doi":"https://doi.org/10.1073/pnas.1005997107","title":"Fas-associated death domain (FADD) is a negative regulator of T-cell receptor\u2013mediated necroptosis","display_name":"Fas-associated death domain (FADD) is a negative regulator of T-cell receptor\u2013mediated necroptosis","publication_year":2010,"publication_date":"2010-07-06","ids":{"openalex":"https://openalex.org/W2073581978","doi":"https://doi.org/10.1073/pnas.1005997107","mag":"2073581978","pmid":"https://pubmed.ncbi.nlm.nih.gov/20615958","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2919948"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1005997107","doi":"https://doi.org/10.1073/pnas.1005997107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1005997107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2919948","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007153038","display_name":"Stephanie L. Osborn","orcid":"https://orcid.org/0000-0002-6020-0077","observed_orcids":["https://orcid.org/0000-0002-6020-0077"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie L. Osborn","raw_affiliation_strings":["Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016586314","display_name":"Gretchen E. Diehl","orcid":"https://orcid.org/0000-0002-1841-2842","observed_orcids":["https://orcid.org/0000-0002-1841-2842"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Gretchen Diehl","raw_affiliation_strings":["Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"raw_affiliation_string":"The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004078112","display_name":"Seong\u2010Ji Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Seong-Ji Han","raw_affiliation_strings":["Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"raw_affiliation_string":"The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110591066","display_name":"Ling Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Ling Xue","raw_affiliation_strings":["Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"raw_affiliation_string":"The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056609060","display_name":"Nadia S. Kurd","orcid":"https://orcid.org/0000-0003-0421-9491","observed_orcids":["https://orcid.org/0000-0003-0421-9491","https://orcid.org/0000-0001-7849-5304"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Nadia Kurd","raw_affiliation_strings":["Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"raw_affiliation_string":"The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069516821","display_name":"Kristina Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Kristina Hsieh","raw_affiliation_strings":["Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"raw_affiliation_string":"The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077988568","display_name":"Dragana Cado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Dragana Cado","raw_affiliation_strings":["Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"raw_affiliation_string":"The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079977765","display_name":"Ellen A. Robey","orcid":"https://orcid.org/0000-0002-3630-5266","observed_orcids":["https://orcid.org/0000-0002-3630-5266"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Ellen A. Robey","raw_affiliation_strings":["Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"raw_affiliation_string":"The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060763507","display_name":"Astar Winoto","orcid":"https://orcid.org/0000-0003-4363-4591","observed_orcids":["https://orcid.org/0000-0003-4363-4591"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Astar Winoto","raw_affiliation_strings":["Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, Canada,","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]},{"raw_affiliation_string":"The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060763507"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476","https://openalex.org/I57206974","https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":6.639,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.97912251,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"107","issue":"29","first_page":"13034","last_page":"13039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.8759999871253967},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/rip1-kinase","display_name":"RIP1 kinase","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ripk3","display_name":"RIPK3","score":0.8889999985694885},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.8960000276565552},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.625},{"id":"https://openalex.org/keywords/t-cell-clonal-expansion","display_name":"T cell clonal expansion","score":0.8029999732971191},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.765999972820282},{"id":"https://openalex.org/keywords/toxoplasmosis","display_name":"toxoplasmosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.9774175882339478},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.9260821342468262},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.7141261696815491},{"id":"https://openalex.org/C2779004061","wikidata":"https://www.wikidata.org/wiki/Q5247322","display_name":"Death domain","level":4,"score":0.7037131190299988},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6738465428352356},{"id":"https://openalex.org/C2776550021","wikidata":"https://www.wikidata.org/wiki/Q18033276","display_name":"RIPK1","level":5,"score":0.630470335483551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6264098882675171},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.4642183780670166},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.4523445665836334},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4203590750694275},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.40422767400741577},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3800147473812103},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.26537519693374634},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24388062953948975},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2033357322216034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07808747887611389}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014123","descriptor_name":"Toxoplasmosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014123","descriptor_name":"Toxoplasmosis","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053422","descriptor_name":"Receptor-Interacting Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053422","descriptor_name":"Receptor-Interacting Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.1005997107","doi":"https://doi.org/10.1073/pnas.1005997107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1005997107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2919948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2919948","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:20615958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20615958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2919948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2919948","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1503848289","https://openalex.org/W1523845694","https://openalex.org/W1616910822","https://openalex.org/W1970506485","https://openalex.org/W1979032223","https://openalex.org/W1981019067","https://openalex.org/W1986978728","https://openalex.org/W1989474275","https://openalex.org/W2004511841","https://openalex.org/W2005138952","https://openalex.org/W2005631373","https://openalex.org/W2012422873","https://openalex.org/W2016345107","https://openalex.org/W2020987391","https://openalex.org/W2031956798","https://openalex.org/W2032917789","https://openalex.org/W2038520262","https://openalex.org/W2052605153","https://openalex.org/W2055132644","https://openalex.org/W2055669325","https://openalex.org/W2058250395","https://openalex.org/W2060204808","https://openalex.org/W2063490958","https://openalex.org/W2069075668","https://openalex.org/W2070058498","https://openalex.org/W2087920955","https://openalex.org/W2104240343","https://openalex.org/W2109317345","https://openalex.org/W2110796758","https://openalex.org/W2111728725","https://openalex.org/W2113414525","https://openalex.org/W2121842388","https://openalex.org/W2122482353","https://openalex.org/W2133868033","https://openalex.org/W2142124752","https://openalex.org/W2143680039","https://openalex.org/W2145341441","https://openalex.org/W2149388384","https://openalex.org/W2158662692","https://openalex.org/W2159965856","https://openalex.org/W2161830466","https://openalex.org/W2166273613","https://openalex.org/W2167430243","https://openalex.org/W2167551229"],"related_works":["https://openalex.org/W1989235336","https://openalex.org/W2089868528","https://openalex.org/W2012422873","https://openalex.org/W2112863026","https://openalex.org/W1616910822","https://openalex.org/W1970234319","https://openalex.org/W2040334186","https://openalex.org/W1548121369","https://openalex.org/W2027946516","https://openalex.org/W1941334139"],"abstract_inverted_index":{"Cell":[0],"death":[1,22,47,53,63],"is":[2,28,35,42,56,158],"an":[3,43,169],"important":[4],"mechanism":[5,218],"to":[6,58,126,136,187,203,219],"limit":[7],"uncontrolled":[8],"T-cell":[9,31,93,152,198,231],"expansion":[10],"during":[11,146,227],"immune":[12],"responses.":[13],"Given":[14],"the":[15,62,87,118,147,176],"role":[16,88],"of":[17,46,89,109,150,166,171,230],"death-receptor":[18],"adapter":[19],"protein":[20],"Fas-associated":[21],"domain":[23],"(FADD)":[24],"in":[25,37,68,82,91,161,225],"apoptosis,":[26],"it":[27],"intriguing":[29],"that":[30,48,142,155,214],"receptor":[32],"(TCR)-induced":[33],"proliferation":[34,94,153],"blocked":[36],"FADD-defective":[38],"T":[39,107,122,163],"cells.":[40,164],"Necroptosis":[41],"alternate":[44],"form":[45],"can":[49],"be":[50],"induced":[51],"by":[52],"receptors":[54],"and":[55,73,95,134,154],"linked":[57],"autophagy.":[59],"It":[60],"requires":[61],"domain-containing":[64],"kinase":[65,173],"RIP1":[66,172],"and,":[67],"certain":[69],"instances,":[70],"RIP3.":[71,192],"FADD":[72,90,102,116,177,215],"its":[74],"apoptotic":[75],"partner,":[76],"Caspase-8,":[77],"have":[78],"also":[79],"been":[80],"implicated":[81],"necroptosis.":[83],"To":[84],"accurately":[85],"assess":[86],"mature":[92,119],"death,":[96],"we":[97],"generated":[98],"a":[99,217],"conditional":[100],"T-cell-specific":[101],"knockout":[103,178],"mouse":[104],"strain.":[105],"The":[106],"cells":[108,123],"these":[110,200],"mice":[111,201],"develop":[112],"normally,":[113],"but":[114],"lack":[115],"at":[117],"stage.":[120],"FADD-deficient":[121,162],"respond":[124],"poorly":[125],"TCR":[127],"triggering,":[128],"exhibit":[129],"slow":[130],"cell":[131],"cycle":[132],"entry,":[133],"fail":[135],"expand":[137],"over":[138],"time.":[139],"We":[140,212],"find":[141],"programmed":[143,222],"necrosis":[144],"occurs":[145],"late":[148],"stage":[149],"normal":[151],"this":[156],"process":[157],"greatly":[159],"amplified":[160],"Inhibition":[165],"necroptosis":[167,183],"using":[168],"inhibitor":[170],"activity":[174],"rescues":[175],"proliferative":[179],"defect.":[180],"However,":[181],"TCR-induced":[182,221],"did":[184],"not":[185],"appear":[186],"require":[188],"autophagy":[189],"or":[190],"involve":[191],"Consistent":[193],"with":[194],"their":[195],"defective":[196],"CD8":[197],"response,":[199],"succumb":[202],"Toxoplasma":[204],"gondii":[205],"infection":[206],"more":[207],"readily":[208],"than":[209],"wild-type":[210],"mice.":[211],"conclude":[213],"constitutes":[216],"keep":[220],"necrotic":[223],"signaling":[224],"check":[226],"early":[228],"phases":[229],"clonal":[232],"expansion.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}