{"id":"https://openalex.org/W2073545951","doi":"https://doi.org/10.1080/01926230490523978","title":"Cisplatin-Induced Renal Interstitial Fibrosis in Neonatal Rats, Developing as Solitary Nephron Unit Lesions","display_name":"Cisplatin-Induced Renal Interstitial Fibrosis in Neonatal Rats, Developing as Solitary Nephron Unit Lesions","publication_year":2005,"publication_date":"2005-01-24","ids":{"openalex":"https://openalex.org/W2073545951","doi":"https://doi.org/10.1080/01926230490523978","mag":"2073545951","pmid":"https://pubmed.ncbi.nlm.nih.gov/15902963"},"language":"en","primary_location":{"id":"doi:10.1080/01926230490523978","doi":"https://doi.org/10.1080/01926230490523978","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01926230490523978","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009514473","display_name":"Jyoji Yamate","orcid":"https://orcid.org/0009-0002-5544-2925","observed_orcids":["https://orcid.org/0009-0002-5544-2925"]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Jyoji Yamate","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054633171","display_name":"Yuuko Machida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuuko Machida","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075311357","display_name":"Mika Ide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mika Ide","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035550385","display_name":"Mitsuru Kuwamura","orcid":"https://orcid.org/0009-0004-6577-2252","observed_orcids":["https://orcid.org/0009-0004-6577-2252"]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuru Kuwamura","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068001270","display_name":"Takao Kotani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Kotani","raw_affiliation_strings":["Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050342671","display_name":"Osamu Sawamoto","orcid":"https://orcid.org/0000-0002-1756-8829","observed_orcids":["https://orcid.org/0000-0002-1756-8829"]},"institutions":[{"id":"https://openalex.org/I114030911","display_name":"Otsuka (Japan)","ror":"https://ror.org/013k5y296","country_code":"JP","type":"company","lineage":["https://openalex.org/I114030911"]},{"id":"https://openalex.org/I4405271247","display_name":"Otsuka Pharmaceutical Factory (Japan)","ror":"https://ror.org/024hzjk66","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405271247"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Sawamoto","raw_affiliation_strings":["Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc, Muya-cho, Naruto, Tokushima 772-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc, Muya-cho, Naruto, Tokushima 772-8601, Japan","institution_ids":["https://openalex.org/I114030911","https://openalex.org/I4405271247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008449484","display_name":"Jonathan LaMarre","orcid":"https://orcid.org/0000-0002-3956-3041","observed_orcids":["https://orcid.org/0000-0002-3956-3041"]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jonathan LaMarre","raw_affiliation_strings":["Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, N 1G2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, N 1G2W1, Canada","institution_ids":["https://openalex.org/I79817857"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009514473"],"corresponding_institution_ids":["https://openalex.org/I15807432"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.3484,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.61445157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"2","first_page":"207","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.10019999742507935,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin-induced-nephrotoxicity","display_name":"cisplatin nephrotoxicity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.8330000042915344},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6489999890327454},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.8460000157356262},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.878000020980835},{"id":"https://openalex.org/keywords/corticomedullary-junction","display_name":"corticomedullary junction","score":0.8389999866485596},{"id":"https://openalex.org/keywords/renal-tubules","display_name":"renal tubules","score":0.5460000038146973},{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.740362286567688},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6894849538803101},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.6285064816474915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.577166736125946},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5544546842575073},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5316503643989563},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5058424472808838},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4408072829246521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2463553547859192},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24283072352409363},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08014664053916931},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009395","descriptor_name":"Nephritis, Interstitial","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009395","descriptor_name":"Nephritis, Interstitial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009395","descriptor_name":"Nephritis, Interstitial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/01926230490523978","doi":"https://doi.org/10.1080/01926230490523978","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01926230490523978","pdf_url":null,"source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:15902963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15902963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W37545008","https://openalex.org/W69293607","https://openalex.org/W224527408","https://openalex.org/W251496494","https://openalex.org/W1240112515","https://openalex.org/W1547475680","https://openalex.org/W1569889800","https://openalex.org/W1749117680","https://openalex.org/W1766380940","https://openalex.org/W1839701843","https://openalex.org/W1967046920","https://openalex.org/W1971591357","https://openalex.org/W1973782465","https://openalex.org/W1977644273","https://openalex.org/W1984650546","https://openalex.org/W1990562824","https://openalex.org/W1990596334","https://openalex.org/W1991736330","https://openalex.org/W1998319967","https://openalex.org/W2007633861","https://openalex.org/W2020902418","https://openalex.org/W2022138192","https://openalex.org/W2027693573","https://openalex.org/W2030356894","https://openalex.org/W2032261477","https://openalex.org/W2032341330","https://openalex.org/W2036369638","https://openalex.org/W2039359299","https://openalex.org/W2041082150","https://openalex.org/W2041964357","https://openalex.org/W2045832382","https://openalex.org/W2047924164","https://openalex.org/W2051184495","https://openalex.org/W2060999075","https://openalex.org/W2065633957","https://openalex.org/W2072750017","https://openalex.org/W2076982071","https://openalex.org/W2080325240","https://openalex.org/W2095253772","https://openalex.org/W2096061509","https://openalex.org/W2099292886","https://openalex.org/W2099714031","https://openalex.org/W2106316471","https://openalex.org/W2120190464","https://openalex.org/W2126232334","https://openalex.org/W2128137492","https://openalex.org/W2130157555","https://openalex.org/W2132963869","https://openalex.org/W2144108073","https://openalex.org/W2146232095","https://openalex.org/W2151040582","https://openalex.org/W2160787474","https://openalex.org/W2181719998","https://openalex.org/W2184817776","https://openalex.org/W2194525164","https://openalex.org/W2303592392","https://openalex.org/W2344353429","https://openalex.org/W2401589271","https://openalex.org/W2406192603","https://openalex.org/W2418011979","https://openalex.org/W2427984515","https://openalex.org/W3184628723"],"related_works":["https://openalex.org/W2047924164","https://openalex.org/W2121619348","https://openalex.org/W617869563","https://openalex.org/W7096606128","https://openalex.org/W2007633861","https://openalex.org/W2144108073","https://openalex.org/W2085056993","https://openalex.org/W3122826549","https://openalex.org/W4396997222","https://openalex.org/W1970185294"],"abstract_inverted_index":{"Cisplatin":[0],"(CDDP)-induced":[1],"renal":[2,151,163,190,236],"lesions":[3,76,98,214,219],"in":[4,26,62,88,113,141,161,235],"rats":[5,29,197],"prove":[6],"a":[7,32],"useful":[8],"model":[9],"for":[10,126,156,185],"analysis":[11],"of":[12,15,35,52,120,166,188,212,243],"the":[13,23,50,89,97,114,118,149,162,186,210,218,223,226],"pathogenesis":[14],"post-tubular":[16],"injury-renal":[17],"interstitial":[18,191,201],"fibrosis.":[19,192],"This":[20],"study":[21],"investigated":[22],"histopathological":[24],"changes":[25],"10-day-old":[27],"neonatal":[28,189],"induced":[30],"by":[31],"single":[33],"injection":[34],"CDDP":[36],"(4.5":[37],"mg/kg).":[38],"Compared":[39,193],"with":[40,56,85,123,194],"age-matched":[41],"controls,":[42],"on":[43,92],"postinjection":[44],"(PI)":[45],"days":[46],"1":[47],"to":[48,78,222,233],"6,":[49],"number":[51],"apoptotic":[53],"cells,":[54],"demonstrable":[55],"TUNEL":[57],"method,":[58],"was":[59,67,158,215],"significantly":[60,146],"increased":[61,147],"CDDP-treated":[63,167],"neonates,":[64],"and":[65,96,133,175,217,240],"there":[66],"no":[68],"marked":[69],"epithelial":[70,164],"necrosis":[71],"nor":[72],"fibrotic":[73,115,213],"lesions.":[74,116],"Fibrotic":[75],"began":[77],"be":[79,183,231],"developed":[80],"solitarily":[81],"around":[82,148,225],"some":[83],"nephrons":[84],"dilated":[86],"ducts":[87],"corticomedullary":[90],"junction":[91],"PI":[93,103],"day":[94,104],"10":[95],"became":[99],"more":[100],"prominent":[101],"until":[102],"20.":[105],"The":[106],"alpha-SMA-positive":[107],"myofibroblastic":[108],"cells":[109,165,177],"were":[110,145,220],"seen":[111,159],"exclusively":[112],"Additionally,":[117],"numbers":[119],"macrophages":[121],"reacting":[122],"EDI":[124],"(specific":[125],"exudate":[127],"macrophages),":[128,132],"ED2":[129],"(for":[130],"resident":[131],"OX6":[134],"(recognizing":[135],"MHC":[136],"class":[137],"II":[138],"antigens":[139],"expressed":[140],"antigen-presenting":[142],"macrophages/dendritic":[143],"cells)":[144],"affected":[150,227],"tubules.":[152],"A":[153],"greater":[154],"immunoreaction":[155],"TGF-beta1":[157,181],"mostly":[160],"neonates.":[168],"These":[169],"findings":[170],"indicated":[171],"that":[172,198],"macrophage":[173],"populations":[174],"myofibrolastic":[176],"as":[178,180],"well":[179],"may":[182],"responsible":[184],"production":[187],"CDDP-injected":[195],"adult":[196,244],"develop":[199],"extensive":[200],"fibrosis":[202],"(Yamate":[203],"et":[204],"al.,":[205],"J":[206],"Comp":[207],"Pathol,":[208],"1995),":[209],"formation":[211],"delayed,":[216],"limited":[221],"area":[224],"nephrons;":[228],"this":[229],"could":[230],"attributable":[232],"differences":[234],"morphology":[237],"between":[238],"neonates":[239],"mature":[241],"kidney":[242],"rats.":[245]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}