{"id":"https://openalex.org/W2073545276","doi":"https://doi.org/10.1210/jcem.83.2.4584","title":"Serum Soluble Interleukin-6 Receptor and Biochemical Markers of Bone Metabolism Show Significant Variations During the Menstrual Cycle","display_name":"Serum Soluble Interleukin-6 Receptor and Biochemical Markers of Bone Metabolism Show Significant Variations During the Menstrual Cycle","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2073545276","doi":"https://doi.org/10.1210/jcem.83.2.4584","mag":"2073545276","pmid":"https://pubmed.ncbi.nlm.nih.gov/9467535"},"language":"en","primary_location":{"id":"doi:10.1210/jcem.83.2.4584","doi":"https://doi.org/10.1210/jcem.83.2.4584","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.83.2.4584","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075789649","display_name":"Itsuo Gorai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Itsuo Gorai","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058545312","display_name":"Yasuto Taguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuto Taguchi","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005030198","display_name":"Osamu Chaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Osamu Chaki","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111816205","display_name":"Ritsuko Kikuchi Masaki Nakayama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ritsuko Kikuchi Masaki Nakayama","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103343438","display_name":"Bing Chen Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing Chen Yang","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110182317","display_name":"Shumpei Yokota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shumpei Yokota","raw_affiliation_strings":["Pediatrics (S.Y.), Yokohama City University School of Medicine, Yokohama 236-8567, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics (S.Y.), Yokohama City University School of Medicine, Yokohama 236-8567, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111440910","display_name":"Hiroshi MINAGUCHI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Minaguchi","raw_affiliation_strings":["Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynecology (I.G., Y.T., O.C., R.K., M.N., B.C.Y., S.Y., H.M.), Yokohama 236-8567, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":8.9881,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.98035406,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"83","issue":"2","first_page":"326","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.6845999956130981,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.6845999956130981,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.2897999882698059,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-il-6-receptor","display_name":"soluble IL-6 receptor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/menstrual-cycle","display_name":"menstrual cycle","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bone-formation-markers","display_name":"bone formation markers","score":0.8840000033378601},{"id":"https://openalex.org/keywords/bone-specific-alkaline-phosphatase","display_name":"bone-specific alkaline phosphatase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/deoxypyridinoline","display_name":"deoxypyridinoline","score":0.9629999995231628},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.7960000038146973},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ovarian-hormones","display_name":"ovarian hormones","score":0.6819999814033508},{"id":"https://openalex.org/keywords/follicular-phase","display_name":"follicular phase","score":0.5960000157356262},{"id":"https://openalex.org/keywords/luteal-phase","display_name":"luteal phase","score":1.0}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8949040174484253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8895565271377563},{"id":"https://openalex.org/C143228043","wikidata":"https://www.wikidata.org/wiki/Q2363481","display_name":"Luteal phase","level":3,"score":0.7341611981391907},{"id":"https://openalex.org/C125870589","wikidata":"https://www.wikidata.org/wiki/Q16959485","display_name":"N-terminal telopeptide","level":5,"score":0.7304620742797852},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6700141429901123},{"id":"https://openalex.org/C2780787237","wikidata":"https://www.wikidata.org/wiki/Q1200841","display_name":"Deoxypyridinoline","level":5,"score":0.5893459916114807},{"id":"https://openalex.org/C2778588143","wikidata":"https://www.wikidata.org/wiki/Q7263584","display_name":"Pyridinoline","level":5,"score":0.5739601254463196},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5531057715415955},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.5499158501625061},{"id":"https://openalex.org/C2779058012","wikidata":"https://www.wikidata.org/wiki/Q83864","display_name":"Menstrual cycle","level":3,"score":0.41256067156791687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3541804254055023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32479584217071533},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2857299745082855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27402210235595703},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.2569013237953186},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.2457488775253296},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008597","descriptor_name":"Menstrual Cycle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011347","descriptor_name":"Procollagen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jcem.83.2.4584","doi":"https://doi.org/10.1210/jcem.83.2.4584","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.83.2.4584","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jc.83.2.326","doi":"https://doi.org/10.1210/jc.83.2.326","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.83.2.326","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:9467535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9467535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320894","display_name":"Abdus Salam International Centre for Theoretical Physics","ror":"https://ror.org/009gyvm78"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1821110234","https://openalex.org/W1887241598","https://openalex.org/W1964343530","https://openalex.org/W1965354004","https://openalex.org/W1966875923","https://openalex.org/W1967215037","https://openalex.org/W1968299184","https://openalex.org/W1972641924","https://openalex.org/W1980786945","https://openalex.org/W1989588004","https://openalex.org/W1996028579","https://openalex.org/W1996758205","https://openalex.org/W1998605268","https://openalex.org/W1999659902","https://openalex.org/W2007614714","https://openalex.org/W2009378649","https://openalex.org/W2010868848","https://openalex.org/W2014148690","https://openalex.org/W2031293802","https://openalex.org/W2033455765","https://openalex.org/W2051344895","https://openalex.org/W2051414204","https://openalex.org/W2053467079","https://openalex.org/W2054845942","https://openalex.org/W2055353584","https://openalex.org/W2058362889","https://openalex.org/W2062729355","https://openalex.org/W2064779138","https://openalex.org/W2066385294","https://openalex.org/W2072567024","https://openalex.org/W2078039950","https://openalex.org/W2087438535","https://openalex.org/W2087734541","https://openalex.org/W2100197809","https://openalex.org/W2104376589","https://openalex.org/W2105873677","https://openalex.org/W2108875090","https://openalex.org/W2112207893","https://openalex.org/W2115932658","https://openalex.org/W2115941653","https://openalex.org/W2122107555","https://openalex.org/W2129449855","https://openalex.org/W2135804654","https://openalex.org/W2140086733","https://openalex.org/W2140674169","https://openalex.org/W2143655684","https://openalex.org/W2153655978","https://openalex.org/W2162308548","https://openalex.org/W2410595201"],"related_works":["https://openalex.org/W1999659902","https://openalex.org/W2051344895","https://openalex.org/W2069732359","https://openalex.org/W2056144289","https://openalex.org/W2106553606","https://openalex.org/W2062008343","https://openalex.org/W2122242665","https://openalex.org/W2072567024","https://openalex.org/W1997071042","https://openalex.org/W2120323055"],"abstract_inverted_index":{"We":[0],"examined":[1],"sequential":[2],"changes":[3,82,284],"of":[4,14,86,88,116,132,165,268,275,298],"bone-resorbing":[5,277],"cytokines":[6],"and":[7,11,50,69,75,102,109,144,153,159,180,185,228,237,249,271,274,310,315],"bone":[8,18,89,133,269],"metabolic":[9],"markers":[10,87,273],"the":[12,21,48,59,73,84,100,122,130,151,176,191,206,209,266,290,295,302],"effect":[13],"ovarian":[15,34],"hormones":[16,288],"on":[17],"metabolism":[19],"during":[20,47,58,72,99,121,150,175,190,205,289],"menstrual":[22,291,303],"cycle":[23,304],"in":[24,83,93,112,265,285,301,313,319],"10":[25],"healthy":[26],"Japanese":[27],"women,":[28],"aged":[29],"22-43":[30],"yr,":[31],"with":[32,219,240],"normal":[33],"function.":[35],"Serum":[36,215],"soluble":[37],"interleukin-6":[38],"receptor":[39],"(sIL-6R)":[40],"showed":[41],"a":[42,45,56,91,110,276],"significant":[43,81],"variation;":[44],"rise":[46,92],"early":[49,60,152,177],"late":[51,76,103,192],"follicular":[52,104,207],"periods":[53,108],"followed":[54],"by":[55,282],"fall":[57,111],"luteal":[61,77,178,193,210],"period":[62,124,194,211],"(P":[63,105,125,170,195,212],"=":[64,67,106,126,171,196,213,223,232,244,253],"0.0423,":[65],"P":[66,225,234,246,255],"0.0334)":[68],"an":[70],"increase":[71],"mid":[74,101],"periods.":[78],"There":[79],"were":[80],"levels":[85,131,267],"formation:":[90],"serum":[94,113,160,186,199,229,238,250,286],"bone-specific":[95],"alkaline":[96],"phosphatase":[97],"(ALP)":[98],"0.0265)":[107],"carboxyl-terminal":[114,163],"propeptide":[115],"type":[117,137,166],"I":[118,138,167],"procollagen":[119],"(PICP)":[120],"midluteal":[123],"0.0161).":[127],"As":[128],"for":[129,307],"resorption":[134,272],"markers,":[135],"urinary":[136,156,181,220],"collagen":[139,168],"C-telopeptide":[140],"breakdown":[141],"products":[142],"(CTx)":[143],"free":[145,157,183],"deoxypyridinoline":[146],"(D-Pyr)":[147],"decreased":[148,188],"significantly":[149,174,189,203,217],"midfollicular":[154],"periods,":[155],"D-Pyr":[158],"pyridinoline":[161],"cross-linked":[162],"telopeptide":[164],"(ICTP)":[169],"0.0440)":[172],"increased":[173],"period,":[179],"CTx,":[182],"D-Pyr,":[184],"ICTP":[187],"0.0170-0.0008).":[197],"The":[198],"PTH":[200],"level":[201],"was":[202],"higher":[204],"than":[208],"0.0132).":[214],"sIL-6R":[216],"correlated":[218],"CTx":[221],"(r":[222,231,243,252],"0.190,":[224],"<":[226,235,247,256],"0.05)":[227,236],"ALP":[230,251],"0.209,":[233],"estradiol":[239],"intact":[241],"osteocalcin":[242],"0.309,":[245],"0.0005)":[248],"0.181,":[254],"0.05).":[257],"These":[258],"observations":[259],"strongly":[260],"suggest":[261],"that":[262],"cyclic":[263,283],"variations":[264],"formation":[270],"cytokine":[278],"may":[279],"be":[280],"modulated":[281],"steroid":[287],"period.":[292],"In":[293],"addition,":[294],"specific":[296],"days":[297],"biochemical":[299],"events":[300],"are":[305],"crucial":[306],"evaluating":[308],"osteoclastic":[309],"osteoblastic":[311],"activities":[312],"pre-":[314],"perimenopausal":[316],"women":[317,320],"or":[318],"starting":[321],"GnRH":[322],"agonist":[323],"therapy.":[324]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}