{"id":"https://openalex.org/W2073527746","doi":"https://doi.org/10.1164/ajrccm.160.2.9810002","title":"Prevention of Chronic Postbronchiolitis Airway Sequelae with IFN- \u03b3 Treatment in Rats","display_name":"Prevention of Chronic Postbronchiolitis Airway Sequelae with IFN- \u03b3 Treatment in Rats","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2073527746","doi":"https://doi.org/10.1164/ajrccm.160.2.9810002","mag":"2073527746","pmid":"https://pubmed.ncbi.nlm.nih.gov/10430749"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.160.2.9810002","doi":"https://doi.org/10.1164/ajrccm.160.2.9810002","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.160.2.9810002","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024137275","display_name":"Ronald L. Sorkness","orcid":"https://orcid.org/0000-0001-5936-1423","observed_orcids":["https://orcid.org/0000-0001-5936-1423"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RONALD L. SORKNESS","raw_affiliation_strings":["Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046012473","display_name":"William L. Castleman","orcid":"https://orcid.org/0000-0002-2868-346X","observed_orcids":["https://orcid.org/0000-0002-2868-346X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WILLIAM L. CASTLEMAN","raw_affiliation_strings":["Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113725635","display_name":"Aparna Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"APARNA KUMAR","raw_affiliation_strings":["Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"MICHAEL R. KAPLAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL R. KAPLAN","raw_affiliation_strings":["Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111993112","display_name":"Robert F. Lemanske","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT F. LEMANSKE","raw_affiliation_strings":["Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin; and Department of Pathobiology, University of Florida, Gainesville, Florida","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2099,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.91947945,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"160","issue":"2","first_page":"705","last_page":"710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.30570000410079956,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/viral-bronchiolitis","display_name":"viral bronchiolitis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.8230000138282776},{"id":"https://openalex.org/keywords/bronchiolar-inflammation","display_name":"bronchiolar inflammation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/airway-fibrosis","display_name":"airway fibrosis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.8939999938011169},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.777999997138977},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.8859999775886536},{"id":"https://openalex.org/keywords/asthma-prevention","display_name":"asthma prevention","score":0.7480000257492065},{"id":"https://openalex.org/keywords/brown-norway-rats","display_name":"Brown Norway rats","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9214499592781067},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5824982523918152},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5474604964256287},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.46370750665664673},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4528752267360687},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.4470771849155426},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.43300557136535645},{"id":"https://openalex.org/C2778821649","wikidata":"https://www.wikidata.org/wiki/Q424227","display_name":"Bronchiolitis","level":3,"score":0.4313783347606659},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.42225801944732666},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.41250866651535034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3460972309112549},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3339328169822693},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24213209748268127},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.16435959935188293},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.15843814611434937}],"mesh":[{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001990","descriptor_name":"Bronchiolitis, Viral","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008170","descriptor_name":"Lung Compliance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010253","descriptor_name":"Respirovirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018108","descriptor_name":"Respirovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1164/ajrccm.160.2.9810002","doi":"https://doi.org/10.1164/ajrccm.160.2.9810002","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.160.2.9810002","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:10430749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10430749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.326.5253","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.5253","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajrccm.atsjournals.org/content/160/2/705.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1169821637","display_name":null,"funder_award_id":"HL-56396","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3131532208","display_name":"SCOR--CELLULAR AND MOLECULAR MECHANISMS OF ASTHMA","funder_award_id":"P50HL056396","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G828371678","display_name":null,"funder_award_id":"AI 34891","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W72079153","https://openalex.org/W116846703","https://openalex.org/W1604654427","https://openalex.org/W1963513289","https://openalex.org/W1983164777","https://openalex.org/W1990990168","https://openalex.org/W1993357286","https://openalex.org/W2019362927","https://openalex.org/W2025463080","https://openalex.org/W2029489668","https://openalex.org/W2047375545","https://openalex.org/W2083903343","https://openalex.org/W2094414184","https://openalex.org/W2124133622","https://openalex.org/W2138478679","https://openalex.org/W2143014879","https://openalex.org/W2151787851","https://openalex.org/W2159997401","https://openalex.org/W2162179591","https://openalex.org/W2276328619","https://openalex.org/W2312397711","https://openalex.org/W2395362254","https://openalex.org/W2597165789","https://openalex.org/W2626318619"],"related_works":["https://openalex.org/W2008683676","https://openalex.org/W2028597107","https://openalex.org/W2157826614","https://openalex.org/W1980363423","https://openalex.org/W1964949763","https://openalex.org/W1976527093","https://openalex.org/W2064011793","https://openalex.org/W1974551699","https://openalex.org/W1996960202","https://openalex.org/W2119007840"],"abstract_inverted_index":{"After":[0],"viral":[1,33,83,170],"bronchiolitis":[2],"at":[3],"an":[4,206],"early":[5,207],"age,":[6],"Brown":[7],"Norway":[8],"(BN)":[9],"rats":[10,46,69],"develop":[11],"chronic":[12,181],"airway":[13,175,182,203],"dysfunction":[14,204],"consisting":[15],"of":[16,28,191,202],"inflammation,":[17],"remodeling,":[18],"episodic":[19],"reversible":[20],"obstruction,":[21],"and":[22,40,64,70,135,140,149],"hyperresponsiveness.":[23],"We":[24,161],"hypothesized":[25],"that":[26,163,173],"supplementation":[27],"interferon":[29,52],"gamma":[30,53],"(IFN-gamma)":[31],"during":[32,105],"illness":[34],"would":[35],"alter":[36],"the":[37,42,106,114,117,125,157,166,189,200],"inflammatory":[38,167],"response":[39,168],"attenuate":[41],"postviral":[43,123,159],"sequelae.":[44],"Weanling":[45],"were":[47],"treated":[48],"daily":[49],"with":[50,66,71,156,205],"aerosolized":[51],"(IFN-gamma),":[54],"from":[55],"2":[56],"d":[57,61],"prior":[58],"through":[59],"7":[60],"after":[62],"inoculation,":[63],"compared":[65,155],"saline-treated":[67],"infected":[68],"noninfected":[72],"control":[73],"rats.":[74],"The":[75],"IFN-gamma":[76,118,126,164],"treatment":[77],"had":[78,119],"no":[79],"significant":[80],"effect":[81],"on":[82,113,122],"titers,":[84],"growth":[85],"retardation,":[86],"or":[87],"total":[88],"bronchoalveolar":[89],"leukocytes,":[90],"but":[91],"there":[92],"was":[93],"a":[94],"slight":[95],"decrease":[96],"in":[97,143],"lung":[98],"interleukin-4":[99],"(IL-4)":[100],"mRNA":[101],"(p":[102,132,137,146,152],"=":[103,133,138,147,153],"0.015)":[104],"first":[107],"week.":[108],"Despite":[109],"having":[110,128],"minimal":[111],"effects":[112,121],"acute":[115,174],"illness,":[116,171],"marked":[120],"sequelae,":[124],"group":[127],"less":[129],"bronchiolar":[130],"inflammation":[131],"0.025)":[134],"fibrosis":[136],"0.01),":[139],"lacking":[141],"abnormalities":[142],"pulmonary":[144],"resistance":[145],"0.028)":[148],"dynamic":[150],"compliance":[151],"0.006)":[154],"untreated":[158],"group.":[160],"conclude":[162],"modulated":[165],"to":[169,188,198],"such":[172],"injury":[176],"did":[177],"not":[178],"evolve":[179],"into":[180],"dysfunction.":[183],"If":[184],"similar":[185],"processes":[186],"contribute":[187],"development":[190],"human":[192],"asthma,":[193],"it":[194],"may":[195],"be":[196],"possible":[197],"interrupt":[199],"progression":[201],"immunomodulatory":[208],"intervention.":[209]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}