{"id":"https://openalex.org/W2073489557","doi":"https://doi.org/10.1159/000216869","title":"Protein S and C4b-Binding Protein Levels in Patients with Stroke: Implications for Protein S Regulation","display_name":"Protein S and C4b-Binding Protein Levels in Patients with Stroke: Implications for Protein S Regulation","publication_year":2009,"publication_date":"2009-04-28","ids":{"openalex":"https://openalex.org/W2073489557","doi":"https://doi.org/10.1159/000216869","mag":"2073489557","pmid":"https://pubmed.ncbi.nlm.nih.gov/8276319"},"language":"en","primary_location":{"id":"doi:10.1159/000216869","doi":"https://doi.org/10.1159/000216869","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000216869","pdf_url":null,"source":{"id":"https://openalex.org/S25130563","display_name":"Haemostasis","issn_l":"0301-0147","issn":["0301-0147","1423-0038"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111713733","display_name":"Marcus E. Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marcus E. Carr, Jr.","raw_affiliation_strings":["Department of Medicine, Medical College of Virginia, Richmond","Coagulation Special Studies Laboratory, Departments of Medicine and Pathology, Medical College of Virginia","Fibrin Studies Laboratory, Department of Medicine, McGuire VA Hospital, Richmond, Va., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Virginia, Richmond","institution_ids":["https://openalex.org/I72019824"]},{"raw_affiliation_string":"Coagulation Special Studies Laboratory, Departments of Medicine and Pathology, Medical College of Virginia","institution_ids":["https://openalex.org/I72019824"]},{"raw_affiliation_string":"Fibrin Studies Laboratory, Department of Medicine, McGuire VA Hospital, Richmond, Va., USA","institution_ids":["https://openalex.org/I2801770128"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004725702","display_name":"Sheryl L. Zekert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheryl L. Zekert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111713733"],"corresponding_institution_ids":["https://openalex.org/I2801770128","https://openalex.org/I72019824"],"apc_list":null,"apc_paid":null,"fwci":0.2131,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61406644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"23","issue":"3","first_page":"159","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-s","display_name":"protein S","score":0.9869999885559082},{"id":"https://openalex.org/keywords/c4b-binding-protein","display_name":"C4b-binding protein","score":0.9929999709129333},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7409999966621399},{"id":"https://openalex.org/keywords/free-protein-s","display_name":"free protein S","score":0.8740000128746033},{"id":"https://openalex.org/keywords/protein-s-deficiency","display_name":"protein S deficiency","score":0.628000020980835},{"id":"https://openalex.org/keywords/protein-c","display_name":"protein C","score":0.6570000052452087},{"id":"https://openalex.org/keywords/binding-dissociation-constant","display_name":"binding dissociation constant","score":0.7239999771118164},{"id":"https://openalex.org/keywords/thrombotic-risk","display_name":"thrombosis risk","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2776135265","wikidata":"https://www.wikidata.org/wiki/Q419774","display_name":"Protein S","level":3,"score":0.8938484191894531},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.727411150932312},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.5835498571395874},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.5374027490615845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.516878604888916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4822460114955902},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4716930687427521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2965991497039795},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28268229961395264},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25623100996017456},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.061580806970596313}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003169","descriptor_name":"Complement Inactivator Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011951","descriptor_name":"Receptors, Complement","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015935","descriptor_name":"Complement C4b","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017293","descriptor_name":"Protein S","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000216869","doi":"https://doi.org/10.1159/000216869","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000216869","pdf_url":null,"source":{"id":"https://openalex.org/S25130563","display_name":"Haemostasis","issn_l":"0301-0147","issn":["0301-0147","1423-0038"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemostasis","raw_type":"journal-article"},{"id":"pmid:8276319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8276319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemostasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W100167056","https://openalex.org/W127753390","https://openalex.org/W2033172000","https://openalex.org/W2018840859","https://openalex.org/W7008992144","https://openalex.org/W1905363000","https://openalex.org/W2074687666","https://openalex.org/W2079729310","https://openalex.org/W1544398217","https://openalex.org/W4231878363"],"abstract_inverted_index":{"Protein":[0],"S":[1,14,31,48,85,94,104,112,128,134,146,158,169,183,186,217,227,238],"circulates":[2],"either":[3,26],"free":[4,12,46,70,92,103,110,126,142,157,166,182,211],"or":[5,29,231],"bound":[6],"to":[7,57,229],"C4b-binding":[8],"protein":[9,13,19,27,30,47,84,93,111,127,133,199,212,216],"(C4b-BP).":[10],"Only":[11],"possesses":[15],"cofactor":[16],"activity":[17],"for":[18,197],"C,":[20],"a":[21,39,60,220],"physiologic":[22],"anticoagulant.":[23],"Deficiencies":[24],"of":[25,52,121,194,210,236,244],"C":[28],"are":[32,241],"associated":[33],"with":[34,44,82,90,100,130,140,164,173,207],"increased":[35,129,148,151],"thrombotic":[36],"risk.":[37],"Over":[38],"23-month":[40],"period,":[41],"40":[42,88],"patients":[43,54,81,89,99,139,163,206],"low":[45,102,165,208],"were":[49,55,116],"identified.":[50],"Eight":[51],"these":[53,245],"found":[56],"have":[58],"suffered":[59],"stroke.":[61,107],"This":[62],"study":[63],"examined":[64],"the":[65,119,144,156,179,198,234],"relationship":[66],"between":[67,181],"total":[68,132,145,168,185],"S,":[69,71,143,167],"and":[72,96,106,109,113,155,184],"C4b-BP":[73,114,150,240],"in":[74,79,87,97,205,233],"15":[75],"healthy":[76,124],"adult":[77],"volunteers,":[78],"20":[80],"normal":[83,141],"levels,":[86,95],"decreased":[91],"8":[98],"combined":[101],"levels":[105,115,209],"Total":[108],"determined":[117],"using":[118],"method":[120],"Laurell.":[122],"In":[123,138,162,176],"adults,":[125],"increasing":[131,174],"(r":[135,152,190],"=":[136,153,191],"0.60).":[137],"level":[147,159],"as":[149],"0.74),":[154],"remained":[160],"constant.":[161],"did":[170],"not":[171],"increase":[172],"C4b-BP.":[175],"stroke":[177],"patients,":[178],"correlation":[180],"was":[187],"actually":[188],"negative":[189],"-0.449).":[192],"Evaluation":[193],"dissociation":[195],"constants":[196],"S-C4b-BP":[200],"complex":[201],"revealed":[202],"enhanced":[203],"binding":[204,218,228,239],"S.":[213],"A":[214],"non-C4b-BP":[215],"protein,":[219],"previously":[221],"undescribed":[222],"regulatory":[223],"factor":[224],"which":[225],"modulates":[226],"C4b-BP,":[230],"shifts":[232],"amount":[235],"non-protein":[237],"possible":[242],"explanations":[243],"results.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
