{"id":"https://openalex.org/W2073487299","doi":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","title":"Modified LDLs induce and bind to membrane ruffles on macrophages","display_name":"Modified LDLs induce and bind to membrane ruffles on macrophages","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W2073487299","doi":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","mag":"2073487299","pmid":"https://pubmed.ncbi.nlm.nih.gov/10321992"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","doi":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0185%2819990501%29255%3A1%3C44%3A%3AAID-AR6%3E3.0.CO%3B2-7","source":{"id":"https://openalex.org/S4210187571","display_name":"The Anatomical Record","issn_l":"0003-276X","issn":["0003-276X","1097-0185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical Record","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0185%2819990501%29255%3A1%3C44%3A%3AAID-AR6%3E3.0.CO%3B2-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nancy L. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nancy L. Jones","raw_affiliation_strings":["Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1092, USA. njones@wfubmc.edu","Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157\u20131092"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1092, USA. njones@wfubmc.edu","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157\u20131092","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110066815","display_name":"Nina Stromgren Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina S. Allen","raw_affiliation_strings":["Department of Biology, North Carolina State University, Raleigh, North Carolina 27695-7612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, North Carolina State University, Raleigh, North Carolina 27695-7612","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085840629","display_name":"Mark C. Willingham","orcid":"https://orcid.org/0000-0002-6576-8809","observed_orcids":["https://orcid.org/0000-0002-6576-8809"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark C. Willingham","raw_affiliation_strings":["Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157\u20131092"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157\u20131092","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112542900","display_name":"Jon C. Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon C. Lewis","raw_affiliation_strings":["Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157\u20131092"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157\u20131092","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.228,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.51259341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"255","issue":"1","first_page":"44","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.2985999882221222,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modified-low-density-lipoprotein","display_name":"modified low-density lipoprotein","score":0.9279999732971191},{"id":"https://openalex.org/keywords/acetylated-ldl","display_name":"acetylated LDL","score":0.9779999852180481},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.9959999918937683},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.781000018119812},{"id":"https://openalex.org/keywords/membrane-ruffling","display_name":"ruffles","score":0.8600000143051147},{"id":"https://openalex.org/keywords/foam-cell-formation","display_name":"foam cell formation","score":0.902999997138977},{"id":"https://openalex.org/keywords/microvilli","display_name":"microvilli","score":0.800000011920929},{"id":"https://openalex.org/keywords/lipoprotein-uptake","display_name":"lipoprotein uptake","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5999088883399963},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.47755321860313416},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.46875524520874023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45139381289482117},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3870007395744324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2420819103717804},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17369186878204346},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16304105520248413}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005487","descriptor_name":"Foam Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005487","descriptor_name":"Foam Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008079","descriptor_name":"Lipoproteins, VLDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010856","descriptor_name":"Columbidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","doi":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0185%2819990501%29255%3A1%3C44%3A%3AAID-AR6%3E3.0.CO%3B2-7","source":{"id":"https://openalex.org/S4210187571","display_name":"The Anatomical Record","issn_l":"0003-276X","issn":["0003-276X","1097-0185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical Record","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.3.co;2-z","doi":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.3.co;2-z","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.3.co;2-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210187571","display_name":"The Anatomical Record","issn_l":"0003-276X","issn":["0003-276X","1097-0185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical Record","raw_type":"journal-article"},{"id":"pmid:10321992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10321992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical record","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","doi":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0185(19990501)255:1<44::aid-ar6>3.0.co;2-7","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0185%2819990501%29255%3A1%3C44%3A%3AAID-AR6%3E3.0.CO%3B2-7","source":{"id":"https://openalex.org/S4210187571","display_name":"The Anatomical Record","issn_l":"0003-276X","issn":["0003-276X","1097-0185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical Record","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2625812743","display_name":"INTERMEDIATE VOLTAGE ELECTRON MICROSCOPY IN MEDICINE","funder_award_id":"5p41rr002722-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4317941545","display_name":"MONOCYTE/MACROPHAGE SUBCELLULAR LIPOPROTEIN PROCESSING","funder_award_id":"5r01hl041990-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7082991545","display_name":"BIOMEDICAL RESEARCH SUPPORT","funder_award_id":"2s07rr005404-31","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7349394847","display_name":null,"funder_award_id":"RR-05404","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8346191769","display_name":null,"funder_award_id":"HL-41990","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8738797","display_name":null,"funder_award_id":"RR0-2722","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320309558","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332689","display_name":"Wake Forest School of Medicine","ror":"https://ror.org/0207ad724"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073487299.pdf","grobid_xml":"https://content.openalex.org/works/W2073487299.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W47222896","https://openalex.org/W109074058","https://openalex.org/W228447933","https://openalex.org/W295866172","https://openalex.org/W337375082","https://openalex.org/W1487922209","https://openalex.org/W1931983289","https://openalex.org/W1964085537","https://openalex.org/W1971405542","https://openalex.org/W1977683248","https://openalex.org/W1985188734","https://openalex.org/W1989300983","https://openalex.org/W2006612457","https://openalex.org/W2012033144","https://openalex.org/W2031934838","https://openalex.org/W2044069721","https://openalex.org/W2048595675","https://openalex.org/W2052394995","https://openalex.org/W2065145876","https://openalex.org/W2076378695","https://openalex.org/W2081796145","https://openalex.org/W2091792425","https://openalex.org/W2112039160","https://openalex.org/W2115048429","https://openalex.org/W2120626817","https://openalex.org/W2153716751","https://openalex.org/W2171303172","https://openalex.org/W2291592525","https://openalex.org/W2296290664","https://openalex.org/W2398175483","https://openalex.org/W2408636018","https://openalex.org/W3140263825","https://openalex.org/W4238726741"],"related_works":["https://openalex.org/W2024364795","https://openalex.org/W7099790469","https://openalex.org/W1983340022","https://openalex.org/W2064398178","https://openalex.org/W3150453456","https://openalex.org/W3141859062","https://openalex.org/W2082573774","https://openalex.org/W2034025726","https://openalex.org/W2011390446","https://openalex.org/W2017980027"],"abstract_inverted_index":{"Macrophage":[0],"foam":[1],"cell":[2],"formation":[3],"in":[4,42,52],"vitro":[5],"requires":[6],"uptake":[7],"of":[8,44,55,105],"modified":[9,135,142],"low":[10,27],"density":[11,28],"lipoproteins":[12],"(LDL)":[13],"such":[14],"as":[15],"acetylated":[16],"LDL":[17,22,117,127],"(AcLDL)":[18],"and":[19,39,68,87,126,141],"moderately":[20],"oxidized":[21],"(OxLDL),":[23],"or":[24,116],"beta-migrating":[25],"very":[26],"lipoprotein":[29],"(betaVLDL),":[30],"a":[31],"naturally":[32],"occurring":[33],"lipoprotein.":[34],"Incubation":[35],"ofmacrophages":[36],"with":[37,113],"AcLDL":[38,97,120],"OxLDL":[40],"resulted":[41,51],"stimulation":[43],"membrane":[45,85,88,102,108,122,139,148],"ruffle":[46,89],"formation,":[47],"while":[48,124],"betaVLDL":[49,115,125],"primarily":[50],"increased":[53],"numbers":[54],"microvilli.":[56],"Time-lapse":[57],"Allen":[58],"video":[59],"enhanced":[60],"contrast":[61,64],"differential":[62],"interference":[63],"(AVEC-DIC)":[65],"light":[66],"microscopy":[67,75],"correlative":[69],"whole":[70],"mount":[71],"intermediate-voltage":[72],"transmission":[73],"electron":[74],"(IVEM)":[76],"was":[77],"used":[78],"to":[79,99,145],"examine":[80],"the":[81,106],"dynamics":[82],"ofAcLDL":[83],"stimulated":[84,121,128],"ruffling":[86],"ultrastructure.":[90],"Stereo":[91],"3D":[92],"surface":[93,109],"replicas":[94],"confirmed":[95,118],"that":[96,119,134],"bound":[98],"these":[100,146],"AcLDL-induced":[101],"ruffles.":[103,149],"Quantification":[104],"plasma":[107],"area":[110],"after":[111],"incubation":[112],"AcLDL,":[114],"ruffling,":[123],"microvilli":[129],"formation.":[130],"These":[131],"studies":[132],"suggest":[133],"LDLs":[136,143],"induce":[137],"circular":[138],"ruffles":[140],"bind":[144],"ligand-induced":[147]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}