{"id":"https://openalex.org/W2073487112","doi":"https://doi.org/10.1016/j.jmb.2011.10.037","title":"Decoding the Molecular Design Principles Underlying Ca2+ Binding to \u03b2\u03b3-Crystallin Motifs","display_name":"Decoding the Molecular Design Principles Underlying Ca2+ Binding to \u03b2\u03b3-Crystallin Motifs","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2073487112","doi":"https://doi.org/10.1016/j.jmb.2011.10.037","mag":"2073487112","pmid":"https://pubmed.ncbi.nlm.nih.gov/22099475"},"language":"en","primary_location":{"id":"doi:10.1016/j.jmb.2011.10.037","doi":"https://doi.org/10.1016/j.jmb.2011.10.037","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2011.10.037","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101597141","display_name":"Amita Mishra","orcid":"https://orcid.org/0000-0002-7303-8697","observed_orcids":["https://orcid.org/0000-0002-7303-8697"]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amita Mishra","raw_affiliation_strings":["Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad 500007, India","Centre for Cellular and Molecular Biology Council of Scientific and Industrial Research, Uppal Road, Hyderabad, 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad 500007, India","institution_ids":["https://openalex.org/I185638415","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Centre for Cellular and Molecular Biology Council of Scientific and Industrial Research, Uppal Road, Hyderabad, 500007, India","institution_ids":["https://openalex.org/I185638415","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046987985","display_name":"Shashi Kumar Suman","orcid":"https://orcid.org/0000-0002-7668-5515","observed_orcids":["https://orcid.org/0000-0002-7668-5515"]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shashi Kumar Suman","raw_affiliation_strings":["Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500007, India","institution_ids":["https://openalex.org/I185638415","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090133072","display_name":"Shanti Swaroop Srivastava","orcid":"https://orcid.org/0000-0002-4208-6127","observed_orcids":["https://orcid.org/0000-0002-4208-6127"]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shanti Swaroop Srivastava","raw_affiliation_strings":["Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500007, India","institution_ids":["https://openalex.org/I185638415","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040415111","display_name":"Rajan Sankaranarayanan","orcid":"https://orcid.org/0000-0003-4524-9953","observed_orcids":["https://orcid.org/0000-0003-4524-9953","https://orcid.org/0000-0001-9683-0372"]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rajan Sankaranarayanan","raw_affiliation_strings":["Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500007, India","institution_ids":["https://openalex.org/I185638415","https://openalex.org/I66760702"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072913194","display_name":"Yogendra Sharma","orcid":"https://orcid.org/0000-0003-1345-8478","observed_orcids":["https://orcid.org/0000-0003-1345-8478"]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Yogendra Sharma","raw_affiliation_strings":["Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500007, India","institution_ids":["https://openalex.org/I185638415","https://openalex.org/I66760702"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040415111","https://openalex.org/A5072913194"],"corresponding_institution_ids":["https://openalex.org/I185638415","https://openalex.org/I66760702"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.3909,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.79799211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"415","issue":"1","first_page":"75","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-binding","display_name":"calcium binding","score":0.8159999847412109},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.45500001311302185},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.5580000281333923},{"id":"https://openalex.org/keywords/binding-site-evolution","display_name":"binding site evolution","score":0.49300000071525574},{"id":"https://openalex.org/keywords/protein-design","display_name":"protein design","score":0.3310000002384186},{"id":"https://openalex.org/keywords/sequence-structure-function-relationships","display_name":"sequence-structure-function relationships","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.7456737756729126},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.6935925483703613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6044577360153198},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5805947184562683},{"id":"https://openalex.org/C187250156","wikidata":"https://www.wikidata.org/wiki/Q2902610","display_name":"Cooperative binding","level":3,"score":0.4865075945854187},{"id":"https://openalex.org/C7263354","wikidata":"https://www.wikidata.org/wiki/Q2992167","display_name":"Crystallin","level":2,"score":0.48037204146385193},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4419100880622864},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.4284001290798187},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4210503101348877},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4131716787815094},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4127548336982727},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3195587992668152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22642096877098083},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11053413152694702}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005417","descriptor_name":"Flavobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046970","descriptor_name":"Clostridium beijerinckii","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jmb.2011.10.037","doi":"https://doi.org/10.1016/j.jmb.2011.10.037","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2011.10.037","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:22099475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22099475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W95394682","https://openalex.org/W1539796472","https://openalex.org/W1545396935","https://openalex.org/W1558495014","https://openalex.org/W1963875432","https://openalex.org/W1968927082","https://openalex.org/W1972739987","https://openalex.org/W1974054783","https://openalex.org/W1975209718","https://openalex.org/W1977835415","https://openalex.org/W1978302916","https://openalex.org/W1978639428","https://openalex.org/W1986191025","https://openalex.org/W1986696619","https://openalex.org/W1989469836","https://openalex.org/W1995017064","https://openalex.org/W1998533680","https://openalex.org/W2001641653","https://openalex.org/W2003312863","https://openalex.org/W2011682316","https://openalex.org/W2016617726","https://openalex.org/W2017593920","https://openalex.org/W2023396840","https://openalex.org/W2023460608","https://openalex.org/W2036440789","https://openalex.org/W2038840577","https://openalex.org/W2040048905","https://openalex.org/W2051025707","https://openalex.org/W2058858274","https://openalex.org/W2065894108","https://openalex.org/W2075379913","https://openalex.org/W2079016964","https://openalex.org/W2086963517","https://openalex.org/W2097493124","https://openalex.org/W2118818078","https://openalex.org/W2142276361","https://openalex.org/W2144081223","https://openalex.org/W2145250917","https://openalex.org/W2162041340","https://openalex.org/W2173218272","https://openalex.org/W2183120559","https://openalex.org/W2334106026"],"related_works":["https://openalex.org/W2070347856","https://openalex.org/W1986696619","https://openalex.org/W2028059958","https://openalex.org/W2321688555","https://openalex.org/W782731916","https://openalex.org/W1978639428","https://openalex.org/W2558115269","https://openalex.org/W2008699385","https://openalex.org/W2023460608","https://openalex.org/W2334106026"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}