{"id":"https://openalex.org/W2073468412","doi":"https://doi.org/10.1513/pats.200603-058ms","title":"Thomas A. Neff Lecture. Chronic Obstructive Pulmonary Disease: A Systemic Disease","display_name":"Thomas A. Neff Lecture. Chronic Obstructive Pulmonary Disease: A Systemic Disease","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2073468412","doi":"https://doi.org/10.1513/pats.200603-058ms","mag":"2073468412","pmid":"https://pubmed.ncbi.nlm.nih.gov/16921116"},"language":"en","primary_location":{"id":"doi:10.1513/pats.200603-058ms","doi":"https://doi.org/10.1513/pats.200603-058ms","is_oa":false,"landing_page_url":"https://doi.org/10.1513/pats.200603-058ms","pdf_url":null,"source":{"id":"https://openalex.org/S128617280","display_name":"Proceedings of the American Thoracic Society","issn_l":"1546-3222","issn":["1546-3222","1943-5665"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the American Thoracic Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054165025","display_name":"Alvar G.N. Agust\u00ed","orcid":"https://orcid.org/0000-0003-3271-3788","observed_orcids":["https://orcid.org/0000-0003-3271-3788"]},"institutions":[{"id":"https://openalex.org/I4210133252","display_name":"Hospital Universitario Son Dureta","ror":"https://ror.org/02ptw3r05","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210133252"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Alvar Agusti","raw_affiliation_strings":["Hospital Universitario Son Dureta and Fundaci\u00f3 Caubet\u2013CIMERA, Palma Mallorca, Spain","Hospital Universitari Son Dureta, Andrea Doria 55, 07014 Palma Mallorca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Son Dureta and Fundaci\u00f3 Caubet\u2013CIMERA, Palma Mallorca, Spain","institution_ids":["https://openalex.org/I4210133252"]},{"raw_affiliation_string":"Hospital Universitari Son Dureta, Andrea Doria 55, 07014 Palma Mallorca, Spain","institution_ids":["https://openalex.org/I4210133252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054165025"],"corresponding_institution_ids":["https://openalex.org/I4210133252"],"apc_list":null,"apc_paid":null,"fwci":8.1895,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.97649288,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"3","issue":"6","first_page":"478","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":1.0},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.4869999885559082},{"id":"https://openalex.org/keywords/peripheral-blood-inflammatory-markers","display_name":"peripheral blood inflammatory markers","score":0.6340000033378601},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cachexia","display_name":"cachexia","score":0.6949999928474426},{"id":"https://openalex.org/keywords/arterial-hypoxemia","display_name":"arterial hypoxemia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/oxygen-therapy","display_name":"oxygen therapy","score":0.7070000171661377},{"id":"https://openalex.org/keywords/copd-management","display_name":"COPD management","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9392938613891602},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.8071170449256897},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.512043297290802},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48081648349761963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26967349648475647}],"mesh":[{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010102","descriptor_name":"Oxygen Inhalation Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016540","descriptor_name":"Smoking Cessation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1513/pats.200603-058ms","doi":"https://doi.org/10.1513/pats.200603-058ms","is_oa":false,"landing_page_url":"https://doi.org/10.1513/pats.200603-058ms","pdf_url":null,"source":{"id":"https://openalex.org/S128617280","display_name":"Proceedings of the American Thoracic Society","issn_l":"1546-3222","issn":["1546-3222","1943-5665"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the American Thoracic Society","raw_type":"journal-article"},{"id":"pmid:16921116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16921116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the American Thoracic Society","raw_type":"Lecture"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.313.4740","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.313.4740","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.goldcopd.it/materiale/gr_lavoro07/2.1/04.pdf","raw_type":"text"},{"id":"mag:2764534946","doi":null,"is_oa":false,"landing_page_url":"http://www.goldcopd.it/materiale/gr_lavoro07/2.1/04.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S128617280","display_name":"Proceedings of the American Thoracic Society","issn_l":"1546-3222","issn":["1546-3222","1943-5665"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the American Thoracic Society","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W201724846","https://openalex.org/W1824777861","https://openalex.org/W1972588215","https://openalex.org/W1973999216","https://openalex.org/W1981878902","https://openalex.org/W1984454286","https://openalex.org/W1988481400","https://openalex.org/W2004030776","https://openalex.org/W2013489935","https://openalex.org/W2045749557","https://openalex.org/W2057115439","https://openalex.org/W2058709767","https://openalex.org/W2071595170","https://openalex.org/W2077395343","https://openalex.org/W2089337998","https://openalex.org/W2090134402","https://openalex.org/W2091806638","https://openalex.org/W2094203991","https://openalex.org/W2094941678","https://openalex.org/W2100822050","https://openalex.org/W2101415295","https://openalex.org/W2104168490","https://openalex.org/W2105166354","https://openalex.org/W2108983987","https://openalex.org/W2110378267","https://openalex.org/W2110872530","https://openalex.org/W2116569033","https://openalex.org/W2116784557","https://openalex.org/W2124631075","https://openalex.org/W2125266996","https://openalex.org/W2128055065","https://openalex.org/W2131471942","https://openalex.org/W2132978348","https://openalex.org/W2140886594","https://openalex.org/W2143180162","https://openalex.org/W2147640669","https://openalex.org/W2156645716","https://openalex.org/W2166432084","https://openalex.org/W2168591827","https://openalex.org/W2170003225","https://openalex.org/W2321320809","https://openalex.org/W2416990511","https://openalex.org/W2614242365","https://openalex.org/W4205209053","https://openalex.org/W4243551229"],"related_works":["https://openalex.org/W2764534946","https://openalex.org/W4282929253","https://openalex.org/W2009370032","https://openalex.org/W2110378267","https://openalex.org/W2231149796","https://openalex.org/W2161856905","https://openalex.org/W2060405242","https://openalex.org/W2067200721","https://openalex.org/W7095958866","https://openalex.org/W1964581150"],"abstract_inverted_index":{"For":[0,55],"the":[1,4,27,110,163,175,179,213,257,260,281],"first":[2,255],"time,":[3],"recently":[5],"published":[6],"American":[7],"Thoracic":[8],"Society/European":[9],"Respiratory":[10],"Society":[11],"chronic":[12,22],"obstructive":[13,23],"pulmonary":[14,24],"disease":[15],"(COPD)":[16],"guidelines":[17],"explicitly":[18],"recognize":[19],"that":[20,49,62,79,112,158,165,234],"\u201calthough":[21],"disease...":[25],"affects":[26],"lungs,":[28],"it":[29,200],"also":[30,192],"produces":[31],"significant":[32,67],"systemic":[33,53,224,263],"consequences":[34,216],"\u201d":[35,76,143,204],"(1).":[36],"This":[37,253],"is":[38,135,150,160,162,167],"somewhat":[39],"surprising":[40],"because":[41],"we":[42,59,105,229],"have":[43,60,106,208],"implicitly":[44],"known":[45,61],"for":[46,100],"many":[47],"years":[48],"COPD":[50,64,116,145,166,250],"indeed":[51],"has":[52],"consequences.":[54],"instance,":[56],"since":[57],"1980,":[58],"severe":[63],"can":[65,83,191],"produce":[66],"arterial":[68],"hypoxemia":[69],"(thus,":[70],"presumably,":[71],"some":[72,113],"degree":[73],"of":[74,109,144,174,181,239,247,262],"\u201csystemic":[75,141,202],"hypoxia)":[77],"and":[78,121,183,215,218,228,242,272,274],"domiciliary":[80],"oxygen":[81],"therapy":[82,221],"improve":[84],"survival":[85],"in":[86,153,195,226,265],"these":[87,235],"patients":[88,114,248],"without":[89],"having":[90],"any":[91],"noticeable":[92],"effect":[93,142],"on":[94],"lung":[95,176],"function":[96],"(2,":[97],"3).":[98],"Likewise,":[99],"more":[101],"than":[102],"30":[103],"years,":[104],"been":[107],"aware":[108],"fact":[111],"with":[115,249],"will":[117,130,287],"develop":[118],"weight":[119],"loss":[120],"eventually":[122],"cachexia":[123],"(\u201cpink":[124],"puffers\u201d),":[125],"whereas":[126],"others":[127],"(\u201cblue":[128],"blotters\u201d)":[129],"not":[131],"(4).":[132],"The":[133],"former":[134],"clearly":[136],"recognized":[137],"now":[138,209],"as":[139,201],"a":[140],"(5,":[146,205,251],"6).":[147,206,252],"So,":[148],"what":[149,159],"really":[151],"new":[152],"this":[154,223],"field?":[155],"I":[156],"believe":[157],"novel":[161],"realization":[164],"characterized":[168],"by":[169],"an":[170],"abnormal":[171],"inflammatory":[172],"response":[173],"parenchyma":[177],"to":[178,211,232,244],"inhalation":[180],"particles":[182],"toxic":[184],"fumes,":[185],"mostly":[186],"tobacco":[187],"smoking":[188],"(1),":[189],"which":[190],"be":[193,238,288],"detected":[194],"peripheral":[196],"blood,":[197],"thus":[198],"qualifying":[199],"inflammation":[203,225,264],"We":[207],"begun":[210],"uncover":[212],"origin":[214,271],"of,":[217],"seek":[219],"potential":[220,270,277],"for,":[222],"COPD,":[227,266],"are":[230],"beginning":[231],"appreciate":[233],"discoveries":[236],"may":[237],"great":[240],"relevance":[241],"lead":[243],"better":[245],"management":[246],"presentation":[254],"reviews":[256],"evidence":[258],"supporting":[259],"presence":[261],"then":[267],"discusses":[268,276],"its":[269],"consequences,":[273],"finally,":[275],"therapeutic":[278],"alternatives.":[279],"Throughout":[280],"text,":[282],"relevant":[283],"questions,":[284],"still":[285],"unanswered,":[286],"identified.":[289]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}