{"id":"https://openalex.org/W2073467167","doi":"https://doi.org/10.1097/00001721-199609000-00012","title":"Use of the direct RNA amplification technique NASBA to detect factor V Leiden, a point mutation associated with APC resistance","display_name":"Use of the direct RNA amplification technique NASBA to detect factor V Leiden, a point mutation associated with APC resistance","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W2073467167","doi":"https://doi.org/10.1097/00001721-199609000-00012","mag":"2073467167","pmid":"https://pubmed.ncbi.nlm.nih.gov/8899156"},"language":"en","primary_location":{"id":"doi:10.1097/00001721-199609000-00012","doi":"https://doi.org/10.1097/00001721-199609000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001721-199609000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation &amp; Fibrinolysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057396192","display_name":"Pieter H. Reitsma","orcid":"https://orcid.org/0000-0003-2207-1830","observed_orcids":["https://orcid.org/0000-0003-2207-1830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. H. Reitsma","raw_affiliation_strings":["Department of Hematology, University Hospital, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Hospital, Leiden, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017561914","display_name":"Pieter A. van der Velden","orcid":"https://orcid.org/0000-0002-5710-9256","observed_orcids":["https://orcid.org/0000-0002-5710-9256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. A. van der Velden","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055916043","display_name":"Esther W.M. Vogels","orcid":"https://orcid.org/0000-0002-5298-2910","observed_orcids":["https://orcid.org/0000-0002-5298-2910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Vogels","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021523398","display_name":"Dianne van Strijp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. van Strijp","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020221508","display_name":"Nicole M. M. Tacken","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Tacken","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021413563","display_name":"Henk J Adriaansen","orcid":"https://orcid.org/0000-0003-0444-0436","observed_orcids":["https://orcid.org/0000-0003-0444-0436"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Adriaansen","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002637298","display_name":"Bob van Gemen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. van Gemen","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4044,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.81359769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"6","first_page":"659","last_page":"659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-v-leiden","display_name":"factor V Leiden","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nasba","display_name":"NASBA","score":0.6100000143051147},{"id":"https://openalex.org/keywords/elga","display_name":"Elga","score":0.6620000004768372},{"id":"https://openalex.org/keywords/venous-thrombosis","display_name":"venous thrombosis","score":0.906000018119812},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.671999990940094},{"id":"https://openalex.org/keywords/factor-v","display_name":"factor V","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.703913152217865},{"id":"https://openalex.org/C2779695955","wikidata":"https://www.wikidata.org/wiki/Q3869370","display_name":"NASBA","level":4,"score":0.5305697321891785},{"id":"https://openalex.org/C2777175894","wikidata":"https://www.wikidata.org/wiki/Q185986","display_name":"Factor V Leiden","level":4,"score":0.48180049657821655},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.45482614636421204},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37146878242492676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3691709637641907},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36809709668159485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3369213938713074},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.32003656029701233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19975325465202332},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15529802441596985},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.07981684803962708},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.06090199947357178}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001779","descriptor_name":"Blood Coagulation Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010314","descriptor_name":"Partial Thromboplastin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013924","descriptor_name":"Thrombophlebitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00001721-199609000-00012","doi":"https://doi.org/10.1097/00001721-199609000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001721-199609000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation &amp; Fibrinolysis","raw_type":"journal-article"},{"id":"pmid:8899156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8899156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W90236147","https://openalex.org/W2007987240","https://openalex.org/W2130416269","https://openalex.org/W1982328813","https://openalex.org/W2465142459","https://openalex.org/W131637596","https://openalex.org/W2153071433","https://openalex.org/W1845599173","https://openalex.org/W1574303849","https://openalex.org/W2414248457"],"abstract_inverted_index":{"APC":[0,69],"resistance":[1,70],"is":[2,53,73],"a":[3,57,67,84,97],"common":[4],"and":[5,59,77],"strong":[6],"hereditary":[7],"risk":[8],"factor":[9,29,48,107],"for":[10,100],"venous":[11],"thrombosis.":[12],"This":[13],"plasma":[14,68],"abnormality":[15],"appears":[16],"to":[17,41,55,66],"be":[18],"almost":[19],"always":[20],"caused":[21],"by":[22,46,75],"the":[23,27,91,101,106],"same":[24],"defect":[25],"in":[26],"coagulation":[28],"V":[30,49,108],"gene":[31],"(a":[32],"G":[33],"-->":[34],"A":[35],"transition":[36],"at":[37],"nucleotide":[38,102],"1691":[39],"leading":[40],"replacement":[42],"of":[43,105],"506":[44],"Arg":[45],"Gln;":[47],"Leiden).":[50],"Therefore,":[51],"it":[52],"possible":[54],"consider":[56],"simple":[58,98],"specific":[60,103],"genetic":[61],"test":[62,71],"as":[63],"an":[64],"alternative":[65],"that":[72],"compromised":[74],"treatment":[76],"other":[78],"factors.":[79],"We":[80],"have":[81],"investigated":[82],"whether":[83],"new":[85],"amplification":[86],"procedure,":[87],"NASBA,":[88],"together":[89],"with":[90],"detection":[92,104],"procedure":[93],"ELGA":[94],"would":[95],"provide":[96],"protocol":[99],"mutation.":[109]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
