{"id":"https://openalex.org/W2073422014","doi":"https://doi.org/10.1002/syn.890170310","title":"Methamphetamine\u2010induced neurotoxicity: Roles for glutamate and dopamine efflux","display_name":"Methamphetamine\u2010induced neurotoxicity: Roles for glutamate and dopamine efflux","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W2073422014","doi":"https://doi.org/10.1002/syn.890170310","mag":"2073422014","pmid":"https://pubmed.ncbi.nlm.nih.gov/7974204"},"language":"en","primary_location":{"id":"doi:10.1002/syn.890170310","doi":"https://doi.org/10.1002/syn.890170310","is_oa":false,"landing_page_url":"https://doi.org/10.1002/syn.890170310","pdf_url":null,"source":{"id":"https://openalex.org/S158211696","display_name":"Synapse","issn_l":"0887-4476","issn":["0887-4476","1098-2396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2073422014"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006971242","display_name":"Stacy E. Stephans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacy E. Stephans","raw_affiliation_strings":["Department of Neuroscience, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-5000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-5000","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042693752","display_name":"Bryan K. Yamamoto","orcid":"https://orcid.org/0000-0001-8101-7733","observed_orcids":["https://orcid.org/0000-0001-8101-7733"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bryan K. Yamamoto","raw_affiliation_strings":["Departments of Neuroscience and Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-5000","Dept. of Psychiatry, University Hospitals of Cleveland, 2040 Abington Rd., Cleveland, OH 44106\u20105000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neuroscience and Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-5000","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Dept. of Psychiatry, University Hospitals of Cleveland, 2040 Abington Rd., Cleveland, OH 44106\u20105000","institution_ids":["https://openalex.org/I2799343972"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042693752"],"corresponding_institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":2.2681,"has_fulltext":false,"cited_by_count":277,"citation_normalized_percentile":{"value":0.89548148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"17","issue":"3","first_page":"203","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.07559999823570251,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.984000027179718},{"id":"https://openalex.org/keywords/dopamine-efflux","display_name":"dopamine efflux","score":0.8420000076293945},{"id":"https://openalex.org/keywords/glutamate-efflux","display_name":"glutamate efflux","score":0.9279999732971191},{"id":"https://openalex.org/keywords/striatal-dopaminergic-neurons","display_name":"striatal dopaminergic neurons","score":0.8569999933242798},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.6919999718666077},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.8259999752044678},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.972000002861023},{"id":"https://openalex.org/keywords/gbr-12909","display_name":"GBR 12909","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C2780114369","wikidata":"https://www.wikidata.org/wiki/Q6823535","display_name":"Meth-","level":5,"score":0.9195065498352051},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.7938210964202881},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7882643938064575},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.7760859727859497},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.760933518409729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7121690511703491},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6551804542541504},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6078109741210938},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5776026248931885},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5384817719459534},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.48444536328315735},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.4738645553588867},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.44610562920570374},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.44228503108024597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26443052291870117},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2626380920410156},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.22956052422523499},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1752631664276123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1725028157234192},{"id":"https://openalex.org/C2779989194","wikidata":"https://www.wikidata.org/wiki/Q343016","display_name":"Acrylate","level":4,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004563","descriptor_name":"Electrochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014179","descriptor_name":"Neurotransmitter Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/syn.890170310","doi":"https://doi.org/10.1002/syn.890170310","is_oa":false,"landing_page_url":"https://doi.org/10.1002/syn.890170310","pdf_url":null,"source":{"id":"https://openalex.org/S158211696","display_name":"Synapse","issn_l":"0887-4476","issn":["0887-4476","1098-2396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse","raw_type":"journal-article"},{"id":"pmid:7974204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7974204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6149472512","display_name":"Methamphetamine Toxicity and Corticostriatal Glutamate","funder_award_id":"R01DA007606","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1791541579","https://openalex.org/W1833844094","https://openalex.org/W1924869647","https://openalex.org/W1961011427","https://openalex.org/W1961847285","https://openalex.org/W1966308032","https://openalex.org/W1975635801","https://openalex.org/W1980765757","https://openalex.org/W1982425449","https://openalex.org/W1983638775","https://openalex.org/W1984777572","https://openalex.org/W1989442300","https://openalex.org/W1996556589","https://openalex.org/W2005952891","https://openalex.org/W2008524165","https://openalex.org/W2010243667","https://openalex.org/W2011301983","https://openalex.org/W2013024853","https://openalex.org/W2022107914","https://openalex.org/W2025445592","https://openalex.org/W2026835867","https://openalex.org/W2031242571","https://openalex.org/W2032950110","https://openalex.org/W2044779910","https://openalex.org/W2048484492","https://openalex.org/W2050452861","https://openalex.org/W2057566122","https://openalex.org/W2058758107","https://openalex.org/W2061589525","https://openalex.org/W2066214697","https://openalex.org/W2072436586","https://openalex.org/W2073424517","https://openalex.org/W2076922712","https://openalex.org/W2086425346","https://openalex.org/W2090140030","https://openalex.org/W2094141023","https://openalex.org/W2094817743","https://openalex.org/W2146904216","https://openalex.org/W2148418924","https://openalex.org/W2164975184","https://openalex.org/W2228073141","https://openalex.org/W2265800422","https://openalex.org/W2410175368"],"related_works":["https://openalex.org/W1963824106","https://openalex.org/W2005952891","https://openalex.org/W2088704249","https://openalex.org/W2066680759","https://openalex.org/W2352590141","https://openalex.org/W2128828064","https://openalex.org/W2067020104","https://openalex.org/W1906682078","https://openalex.org/W2109732720","https://openalex.org/W2053320493"],"abstract_inverted_index":{"The":[0,42,153],"neurotoxic":[1],"effects":[2,39],"of":[3,40,44,70,78,136,215,243],"methamphetamine":[4],"(METH)":[5],"on":[6,221],"striatal":[7,71,126],"dopaminergic":[8],"neurons":[9],"have":[10],"been":[11],"hypothesized":[12],"to":[13,48,56,66,169],"be":[14],"mediated":[15],"by":[16,114,163,196],"excess":[17],"dopamine":[18],"(DA)":[19],"release.":[20],"In":[21,59,122,133,172],"addition,":[22],"N-methyl-D-aspartate":[23],"(NMDA)":[24],"receptor":[25],"antagonists":[26],"block":[27],"METH-induced":[28,57,150,244],"DA":[29,51,72,106,127,151,170,177,193,216,228],"depletions.":[30],"This":[31],"suggests":[32],"that":[33,50,226],"glutamate":[34,53,74,161,202,230],"also":[35],"mediates":[36],"the":[37,92,99,111,118,144,157,176,191,211,218,233,241],"toxic":[38],"METH.":[41],"purpose":[43],"this":[45],"study":[46],"is":[47],"demonstrate":[49],"and":[52,73,98,165,229,237],"efflux":[54],"contribute":[55],"neurotoxicity.":[58,245],"vivo":[60],"microdialysis":[61],"in":[62,110,160,217,232,240],"rats":[63,95],"was":[64,130],"used":[65],"measure":[67],"extracellular":[68,158],"concentrations":[69,109],"following":[75,91],"3":[76],"injections":[77],"METH":[79,120,146,164,187,197],"(10":[80,181],"mg/kg,":[81,182],"i.p.),":[82],"each":[83,186],"injection":[84],"given":[85],"2":[86],"hours":[87],"apart.":[88],"One":[89],"week":[90],"dialysis":[93],"experiment,":[94],"were":[96,103],"sacrificed":[97],"ventral":[100],"lateral":[101],"striata":[102],"assayed":[104],"for":[105],"content.":[107],"Glutamate":[108],"dialysate":[112],"increased":[113,149,192,227],"over":[115],"4-fold":[116],"after":[117],"third":[119],"injection.":[121],"these":[123,222],"same":[124],"animals,":[125],"tissue":[128,212],"content":[129,213],"significantly":[131,148,189],"depleted.":[132],"separate":[134],"groups":[135],"rats,":[137],"pretreatment":[138,155,174,205],"with":[139,175,206],"haloperidol":[140,154],"(2":[141],"mg/kg":[142],"at":[143],"first":[145],"injection)":[147,188],"efflux.":[152,203],"attenuated":[156,190],"increase":[159],"produced":[162,195],"blocked":[166],"subsequent":[167],"neurotoxicity":[168],"neurons.":[171],"contrast,":[173],"uptake":[178],"blocker,":[179],"GBR-12909":[180,207],"30":[183],"min":[184],"before":[185],"release":[194,231],"but":[198],"did":[199,208],"not":[200],"change":[201],"However,":[204],"protect":[209],"against":[210],"depletion":[214],"striatum.":[219],"Based":[220],"findings,":[223],"it":[224],"appears":[225],"striatum":[234],"are":[235],"important":[236],"possibly":[238],"interact":[239],"development":[242]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}