{"id":"https://openalex.org/W2073370132","doi":"https://doi.org/10.1016/j.jalz.2007.04.019","title":"O2\u201305\u201303: Stable trimeric A\u2010beta peptides: Potential vaccine immunogens to prevent ADDL\u2010triggered memory deficits","display_name":"O2\u201305\u201303: Stable trimeric A\u2010beta peptides: Potential vaccine immunogens to prevent ADDL\u2010triggered memory deficits","publication_year":2007,"publication_date":"2007-06-04","ids":{"openalex":"https://openalex.org/W2073370132","doi":"https://doi.org/10.1016/j.jalz.2007.04.019","mag":"2073370132"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2007.04.019","doi":"https://doi.org/10.1016/j.jalz.2007.04.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2007.04.019","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2007.04.019","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2007.04.019","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081926493","display_name":"Grant A. Krafft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160595","display_name":"Acumen Pharmaceuticals (United States)","ror":"https://ror.org/05pvq8q22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210160595"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Grant A. Krafft","raw_affiliation_strings":["Acumen Pharmaceuticals, South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acumen Pharmaceuticals, South San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210160595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081926493"],"corresponding_institution_ids":["https://openalex.org/I4210160595"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.1138,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41289805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"3S_Part_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C2779909307","wikidata":"https://www.wikidata.org/wiki/Q1660181","display_name":"Immunogen","level":4,"score":0.7710257768630981},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.7029197216033936},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.49275949597358704},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.4664193093776703},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4553232491016388},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4547809660434723},{"id":"https://openalex.org/C179223381","wikidata":"https://www.wikidata.org/wiki/Q419425","display_name":"Avidity","level":3,"score":0.4508237838745117},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.432589054107666},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3087891936302185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.296366810798645},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2530719041824341},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.23734226822853088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1668788194656372},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2007.04.019","doi":"https://doi.org/10.1016/j.jalz.2007.04.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2007.04.019","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2007.04.019","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2007.04.019","doi":"https://doi.org/10.1016/j.jalz.2007.04.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2007.04.019","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2007.04.019","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073370132.pdf","grobid_xml":"https://content.openalex.org/works/W2073370132.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7008080089","https://openalex.org/W2007358579","https://openalex.org/W2883424851","https://openalex.org/W2091308257","https://openalex.org/W2896855117","https://openalex.org/W2912268839","https://openalex.org/W2366076174","https://openalex.org/W3019507793","https://openalex.org/W3022025949","https://openalex.org/W2624476852"],"abstract_inverted_index":{"The":[0,51],"picture":[1],"of":[2,49,81,98,105,130,137,149,177],"Alzheimer's":[3],"disease":[4],"has":[5],"changed":[6],"dramatically":[7],"over":[8],"the":[9,23,93,175],"past":[10],"decade,":[11],"as":[12,22],"emerging":[13],"data":[14],"now":[15,31],"implicate":[16],"amyloid":[17],"\u03b2-derived":[18],"diffusible":[19],"ligands":[20],"(ADDLs)":[21],"key":[24,127],"memory-compromising":[25],"molecules":[26],"responsible":[27],"for":[28],"AD.":[29,208],"We":[30,116,172,190],"understand":[32],"that":[33,102,181,192],"ADDLs":[34],"assemble":[35],"from":[36],"elevated":[37],"A\u03b242,":[38],"and":[39,62,95,121,159],"they":[40],"selectively":[41],"attack":[42],"dendritic":[43],"spine":[44],"receptors":[45],"on":[46],"a":[47,183],"subset":[48],"neurons.":[50],"ensuing":[52],"signals":[53],"disrupt":[54],"long-term":[55],"potentiation":[56],"(LTP),":[57],"leading":[58],"to":[59,125,166,206],"compromised":[60],"learning":[61],"memory.":[63],"In":[64],"connection":[65],"with":[66,84,140,153,203],"our":[67],"collaborative":[68],"ADDL-directed":[69],"therapeutic":[70],"antibody":[71],"program,":[72],"we":[73],"developed":[74],"novel":[75,144],"trimeric":[76,99,145],"A\u03b2":[77,132,195],"peptide":[78],"immunogens":[79,101,139,146,180],"capable":[80,148],"generating":[82,178],"antibodies":[83,152],"potent":[85,154],"ADDL":[86,107,155,185],"assembly":[87,156,186],"blocking":[88,157,187],"activity.":[89,162],"This":[90],"study":[91],"targets":[92],"design":[94,136],"pre-clinical":[96],"development":[97],"vaccine":[100,138,179],"trigger":[103],"production":[104],"selective":[106],"assembly-blocking":[108],"antibodies,":[109],"without":[110],"accompanying":[111],"anti-monomer":[112,161],"or":[113],"anti-fibril":[114],"antibodies.":[115],"have":[117,173],"deployed":[118],"molecular":[119],"dynamics":[120],"2D":[122],"NMR":[123],"studies":[124],"reveal":[126],"structural":[128],"aspects":[129],"stable":[131],"analog":[133],"trimers,":[134],"allowing":[135],"optimized":[141,169],"properties.":[142],"Several":[143],"are":[147,164],"triggering":[150],"polyclonal":[151],"activity":[158],"minimal":[160],"Studies":[163],"continuing":[165],"generate":[167,182],"an":[168],"IND-candidate":[170],"immunogen.":[171],"demonstrated":[174],"feasibility":[176],"trimer-specific,":[184],"immune":[188],"response.":[189],"believe":[191],"vaccines":[193],"targeting":[194],"trimers":[196],"will":[197],"be":[198],"highly":[199],"effective":[200],"AD":[201],"therapeutics":[202],"great":[204],"potential":[205],"prevent":[207]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}