{"id":"https://openalex.org/W2073362811","doi":"https://doi.org/10.4161/cbt.5.10.3453","title":"Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: Heteroduplex analysis of limiting dilution PCRs","display_name":"Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: Heteroduplex analysis of limiting dilution PCRs","publication_year":2006,"publication_date":"2006-10-11","ids":{"openalex":"https://openalex.org/W2073362811","doi":"https://doi.org/10.4161/cbt.5.10.3453","mag":"2073362811","pmid":"https://pubmed.ncbi.nlm.nih.gov/17106238"},"language":"en","primary_location":{"id":"doi:10.4161/cbt.5.10.3453","doi":"https://doi.org/10.4161/cbt.5.10.3453","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.5.10.3453","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.5.10.3453?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.5.10.3453?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112904705","display_name":"Yansong Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yansong Bian","raw_affiliation_strings":["Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036877791","display_name":"Hiroyuki Matsubayashi","orcid":"https://orcid.org/0000-0002-7050-2351","observed_orcids":["https://orcid.org/0000-0002-7050-2351"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroyuki Matsubayashi","raw_affiliation_strings":["Departments of 1 Pathology , Medicine and","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Pathology , Medicine and","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042673919","display_name":"Chung\u2010Pin Li","orcid":"https://orcid.org/0000-0003-2123-8264","observed_orcids":["https://orcid.org/0000-0003-2123-8264"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung-Pin Li","raw_affiliation_strings":["Departments of 1 Pathology , Medicine and","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Pathology , Medicine and","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076947350","display_name":"Tadayoshi Abe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tadayoshi Abe","raw_affiliation_strings":["Departments of 1 Pathology , Medicine and","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Pathology , Medicine and","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039731184","display_name":"Marcia Irene Canto","orcid":"https://orcid.org/0000-0002-2193-3032","observed_orcids":["https://orcid.org/0000-0002-2193-3032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcia I. Canto","raw_affiliation_strings":["Departments of 1 Pathology , Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Pathology , Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101769237","display_name":"Kathleen M. Murphy","orcid":"https://orcid.org/0000-0001-5840-9384","observed_orcids":["https://orcid.org/0000-0001-5840-9384"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen M. Murphy","raw_affiliation_strings":["Departments of 1 Pathology , Medicine and","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Pathology , Medicine and","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090286753","display_name":"Michael Goggins","orcid":"https://orcid.org/0000-0002-4286-2296","observed_orcids":["https://orcid.org/0000-0002-4286-2296"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Goggins","raw_affiliation_strings":["Departments of Pathology, Medicine and Oncology ; The Sol Goldman Center for Pancreatic Cancer Research ; The Johns Hopkins Medical Institutions ; 342 CRB2 ; 1550 Orleans Street ; Baltimore , Maryland 21231 USA;","Oncology ; The Sol Goldman Center for Pancreatic Cancer Research ; The Johns Hopkins Medical Institutions ; Baltimore , Maryland USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Medicine and Oncology ; The Sol Goldman Center for Pancreatic Cancer Research ; The Johns Hopkins Medical Institutions ; 342 CRB2 ; 1550 Orleans Street ; Baltimore , Maryland 21231 USA;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Oncology ; The Sol Goldman Center for Pancreatic Cancer Research ; The Johns Hopkins Medical Institutions ; Baltimore , Maryland USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":null,"fwci":1.0402,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.76943858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"10","first_page":"1392","last_page":"1399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.08100000023841858,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p16-mutation","display_name":"p16 mutation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-juice","display_name":"pancreatic juice","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8009999990463257},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/heteroduplex-analysis","display_name":"heteroduplex analysis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mutation-detection-sensitivity","display_name":"mutation detection sensitivity","score":0.5960000157356262},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C57380142","wikidata":"https://www.wikidata.org/wiki/Q863089","display_name":"Pancreatic juice","level":3,"score":0.7992696166038513},{"id":"https://openalex.org/C134494468","wikidata":"https://www.wikidata.org/wiki/Q408140","display_name":"Heteroduplex","level":3,"score":0.7579073905944824},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7146226167678833},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.6694260239601135},{"id":"https://openalex.org/C2779960720","wikidata":"https://www.wikidata.org/wiki/Q668063","display_name":"Pancreatic duct","level":3,"score":0.5843936800956726},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49250325560569763},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.47979480028152466},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4787273108959198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4478515088558197},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4381110668182373},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43763408064842224},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4118348956108093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33889585733413696},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3082703649997711},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2756271958351135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2586115002632141},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24332976341247559},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16837778687477112},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010182","descriptor_name":"Pancreatic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010182","descriptor_name":"Pancreatic Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010189","descriptor_name":"Pancreatic Juice","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019942","descriptor_name":"Genes, p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4161/cbt.5.10.3453","doi":"https://doi.org/10.4161/cbt.5.10.3453","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.5.10.3453","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.5.10.3453?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:17106238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17106238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cbt.5.10.3453","doi":"https://doi.org/10.4161/cbt.5.10.3453","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.5.10.3453","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.5.10.3453?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6600000262260437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1743887175","display_name":"Markers of Early Pancreatic Cancer","funder_award_id":"R01CA120432","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8373782936","display_name":"SPORE in Gastrointestinal Cancers","funder_award_id":"P50CA062924","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G970037175","display_name":null,"funder_award_id":"CA 62924","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320317822","display_name":"Rolfe Pancreatic Cancer Foundation","ror":"https://ror.org/02p524v68"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073362811.pdf","grobid_xml":"https://content.openalex.org/works/W2073362811.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2103889636","https://openalex.org/W2018421391","https://openalex.org/W2805389863","https://openalex.org/W2912832290","https://openalex.org/W2005015259","https://openalex.org/W187466779","https://openalex.org/W2475585734","https://openalex.org/W3029319669","https://openalex.org/W4386098200","https://openalex.org/W1998531538"],"abstract_inverted_index":{"We":[0,15,121],"have":[1],"developed":[2],"a":[3],"simple,":[4],"robust,":[5],"highly-sensitive":[6],"assay":[7,18,39],"for":[8,54,131],"identifying":[9],"gene":[10],"mutations":[11,24,55,75,82,136,148],"in":[12,25,76,83,89,137],"clinical":[13,138],"samples.":[14],"applied":[16,142],"this":[17],"to":[19,63,102,143,146],"detect":[20,147],"p53":[21,84,150],"and":[22,33,140],"p16":[23,86],"pancreatic":[26,36,77,91,99,118,144,159,166],"juice":[27,92,145],"obtained":[28],"from":[29,161],"patients":[30,107,157],"undergoing":[31],"evaluation":[32],"treatment":[34],"of":[35,73,93,95,105,112,117,135,149,165],"disease.":[37],"The":[38],"strategy":[40,130],"involves":[41],"PCR":[42,52,126],"amplifying":[43],"DNA":[44],"at":[45],"limiting":[46,124],"dilution":[47,125],"(LD-PCR)":[48],"followed":[49],"by":[50],"screening":[51],"products":[53],"using":[56],"temperature":[57],"gradient":[58],"capillary":[59],"electrophoresis":[60],"(TGCE).":[61],"Compared":[62],"conventional":[64],"TGCE,":[65],"TGCE":[66],"after":[67],"LD-PCR":[68],"significantly":[69],"increased":[70],"the":[71,90,133],"number":[72],"detectable":[74],"duct":[78],"juice.":[79],"Using":[80],"LD-PCR,":[81],"and/or":[85,151],"were":[87],"found":[88],"12":[94],"20":[96],"individuals":[97,114],"with":[98,108,158],"cancer":[100,160],"compared":[101],"only":[103],"1":[104],"8":[106,113],"chronic":[109],"pancreatitis,":[110],"0":[111],"without":[115,163],"evidence":[116,164],"disease":[119],"(p<0.02).":[120],"conclude":[122],"that":[123],"is":[127],"an":[128],"effective":[129],"improving":[132],"detection":[134],"samples":[139],"when":[141],"p16,":[152],"it":[153],"can":[154],"help":[155],"distinguish":[156],"those":[162],"neoplasia.":[167]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}