{"id":"https://openalex.org/W2073334126","doi":"https://doi.org/10.1186/cc13006","title":"Evaluation of compound NXY-059 on cognitive impairment caused by sepsis","display_name":"Evaluation of compound NXY-059 on cognitive impairment caused by sepsis","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2073334126","doi":"https://doi.org/10.1186/cc13006","mag":"2073334126"},"language":"en","primary_location":{"id":"doi:10.1186/cc13006","doi":"https://doi.org/10.1186/cc13006","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc13006","pdf_url":"https://ccforum.biomedcentral.com/track/pdf/10.1186/cc13006","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/track/pdf/10.1186/cc13006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nath\u00e1lia S Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Nath\u00e1lia S Oliveira","raw_affiliation_strings":["Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966"]},{"raw_affiliation_string":"Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010442506","display_name":"Monica Farah Pereira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Monica F Pereira","raw_affiliation_strings":["Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966"]},{"raw_affiliation_string":"Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110104401","display_name":"Mariana da Cunha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana GAT Cunha","raw_affiliation_strings":["Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966"]},{"raw_affiliation_string":"Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018665139","display_name":"Silvio J\u00fanior","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvio CA J\u00fanior","raw_affiliation_strings":["Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966"]},{"raw_affiliation_string":"Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108431869","display_name":"Rachel N. Gomes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rachel N Gomes","raw_affiliation_strings":["Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966"]},{"raw_affiliation_string":"Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104107374","display_name":"Patr\u00edcia A. Reis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Patr\u00edcia A Reis","raw_affiliation_strings":["Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966"]},{"raw_affiliation_string":"Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109321252","display_name":"Robert A. Floyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Floyd","raw_affiliation_strings":["Oklahoma Medical Research Foundation, Oklahoma, OK, USA","Oklahoma Medical Research Foundation, Oklahoma, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Medical Research Foundation, Oklahoma, OK, USA","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Oklahoma Medical Research Foundation, Oklahoma, USA","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110142546","display_name":"Hugo CCF Neto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hugo CCF Neto","raw_affiliation_strings":["Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I4405286966"]},{"raw_affiliation_string":"Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405286966"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"Suppl 4","first_page":"P107","last_page":"P107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.4120999872684479,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.4120999872684479,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.3788999915122986,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.15109999477863312,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nxy-059","display_name":"NXY-059","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ventilator-associated-conditions","display_name":"ventilator-associated conditions","score":0.6610000133514404},{"id":"https://openalex.org/keywords/ventilator-associated-pneumonia","display_name":"ventilator-associated pneumonia","score":0.9589999914169312},{"id":"https://openalex.org/keywords/national-healthcare-safety-network","display_name":"National Healthcare Safety Network","score":0.7459999918937683},{"id":"https://openalex.org/keywords/automated-surveillance","display_name":"automated surveillance","score":0.6140000224113464},{"id":"https://openalex.org/keywords/attributable-mortality","display_name":"attributable mortality","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9182498455047607},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.7516022324562073},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5792834758758545},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.44764068722724915},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4150887131690979},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36444902420043945},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33858439326286316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2584356367588043},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2013475000858307}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/cc13006","doi":"https://doi.org/10.1186/cc13006","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc13006","pdf_url":"https://ccforum.biomedcentral.com/track/pdf/10.1186/cc13006","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2940237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3952373","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3952373","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3952373","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/cc13006","doi":"https://doi.org/10.1186/cc13006","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc13006","pdf_url":"https://ccforum.biomedcentral.com/track/pdf/10.1186/cc13006","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1569017989","display_name":null,"funder_award_id":"P09/016-F","funder_id":"https://openalex.org/F4320328212","funder_display_name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia"},{"id":"https://openalex.org/G5360611269","display_name":null,"funder_award_id":"1008860","funder_id":"https://openalex.org/F4320322502","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul"},{"id":"https://openalex.org/G6606761772","display_name":null,"funder_award_id":"1008860","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320316811","display_name":"Postgraduate Institute of Medical Education and Research, Chandigarh","ror":"https://ror.org/009nfym65"},{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322502","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","ror":"https://ror.org/05k49za97"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"},{"id":"https://openalex.org/F4320324628","display_name":"Sociedade Beneficente Israelita Brasileira Albert Einstein","ror":"https://ror.org/04cwrbc27"},{"id":"https://openalex.org/F4320327939","display_name":"Universidade do Extremo Sul Catarinense","ror":"https://ror.org/052z2q786"},{"id":"https://openalex.org/F4320328212","display_name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia","ror":"https://ror.org/05j6ybs54"},{"id":"https://openalex.org/F4320329591","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073334126.pdf","grobid_xml":"https://content.openalex.org/works/W2073334126.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W612427471","https://openalex.org/W1576411973","https://openalex.org/W1802210496","https://openalex.org/W1974946709","https://openalex.org/W1977391800","https://openalex.org/W1977905350","https://openalex.org/W1990858588","https://openalex.org/W1996889932","https://openalex.org/W1999946358","https://openalex.org/W2004477905","https://openalex.org/W2005073840","https://openalex.org/W2015455572","https://openalex.org/W2019859146","https://openalex.org/W2022220401","https://openalex.org/W2027855860","https://openalex.org/W2031679095","https://openalex.org/W2032851472","https://openalex.org/W2035206176","https://openalex.org/W2059266505","https://openalex.org/W2069809822","https://openalex.org/W2080979578","https://openalex.org/W2086254631","https://openalex.org/W2086812807","https://openalex.org/W2088220499","https://openalex.org/W2092467979","https://openalex.org/W2106489425","https://openalex.org/W2131607023","https://openalex.org/W2132067161","https://openalex.org/W2146763135","https://openalex.org/W2147135871","https://openalex.org/W2147802195","https://openalex.org/W2148261342","https://openalex.org/W2151426785","https://openalex.org/W2156734795","https://openalex.org/W2157011582","https://openalex.org/W2163865122","https://openalex.org/W2165158988","https://openalex.org/W2169350898","https://openalex.org/W2321192806","https://openalex.org/W2442246762","https://openalex.org/W4230150188"],"related_works":["https://openalex.org/W1967583119","https://openalex.org/W2094378465","https://openalex.org/W2043795737","https://openalex.org/W1984900313","https://openalex.org/W2067936379","https://openalex.org/W2148791788","https://openalex.org/W1975530397","https://openalex.org/W2074995205","https://openalex.org/W2037114961","https://openalex.org/W2158722738"],"abstract_inverted_index":{"Background:":[0],"Reliable":[1],"surveillance":[2,19,99,140,228],"methods":[3],"are":[4],"indispensable":[5],"for":[6,38],"benchmarking":[7],"of":[8,20,47,54,61,114,131,153,171,199,237],"healthcare-associated":[9],"infection":[10],"rates.The":[11],"National":[12],"Healthcare":[13],"Safety":[14],"Network":[15],"(NHSN)":[16],"recently":[17],"introduced":[18],"ventilator-associated":[21,25,62],"events":[22,248],"(VAE),":[23],"including":[24],"conditions":[26],"(VAC)":[27],"[1].This":[28],"new":[29],"algorithm":[30,75,149,192,232,240],"is":[31],"amenable":[32],"to":[33,72,92],"automated":[34,48],"implementation":[35,236],"and":[36,45,50,95,102,110,125,193,218,229,250],"strives":[37],"more":[39],"consistent":[40],"interpretation.We":[41],"assess":[42],"the":[43,82,108,164,168,185,190,194,230,238,247,255],"feasibility":[44],"reliability":[46],"implementation.Materials":[49],"methods:":[51],"Retrospective":[52],"analysis":[53],"an":[55],"ICU":[56],"cohort":[57],"with":[58,97,184],"prospective":[59,111],"assessment":[60],"pneumonia":[63],"(VAP)":[64],"in":[65],"two":[66],"academic":[67],"medical":[68],"centers":[69],"(January":[70],"2011":[71],"June":[73],"2012).The":[74],"was":[76,105,116,136,161,180,197,233,241],"electronically":[77],"implemented":[78],"as":[79],"specified":[80],"by":[81,118,156,203],"NHSN":[83],"using":[84,261],"minuteto-minute":[85],"ventilator":[86],"data.Two":[87],"minor":[88],"modifications":[89],"were":[90,177],"developed":[91],"improve":[93],"stability":[94],"comparability":[96,258],"manual":[98,226,265],"(10th":[100],"percentile":[101,166,214],"intermittent":[103,186,219],"ventilation).Concordance":[104],"assessed":[106],"between":[107,189,225],"algorithms":[109],"surveillance.Attributable":[112],"mortality":[113,201],"VAC":[115,148,172,206],"estimated":[117],"multivariable":[119],"competing-risk":[120],"survival":[121],"analysis.Results:":[122],"Two":[123],"thousand":[124],"eighty":[126],"patients":[127,154],"contributed":[128],"2,296":[129],"episodes":[130],"mechanical":[132],"ventilation":[133,187,220],"(MV).VAC":[134],"incidence":[135,179],"10.0/1,000":[137],"MV":[138,145,182],"days.Prospective":[139],"identified":[141,167],"8":[142],"VAP":[143,227],"cases/1,000":[144],"days.The":[146],"original":[147,191,205],"detected":[150,249],"32%":[151],"(38/115)":[152],"affected":[155],"VAP;":[157],"positive":[158],"predictive":[159],"value":[160],"25%":[162],"(38/152).Using":[163],"10th":[165,213],"same":[169],"number":[170],"cases,":[173],"but":[174],"only":[175],"116":[176],"identical.VAC":[178],"24.9/1,000":[181],"days":[183],"modification.Concordance":[188],"modified":[195],"versions":[196],"suboptimal.Estimates":[198],"attributable":[200],"varied":[202],"implementation:":[204],"subdistribution":[207],"hazard":[208],"ratio":[209],"(sdHR)":[210],"=":[211,216,222],"4.33,":[212],"sdHR":[215,221],"6.26":[217],"2.40.Conclusions:":[223],"Concordance":[224],"VAE":[231,239],"poor.Although":[234],"electronic":[235,263],"feasible,":[242],"small":[243],"variations":[244],"considerably":[245],"altered":[246],"their":[251],"effect":[252],"on":[253],"mortality.Using":[254],"current":[256],"specifications,":[257],"across":[259],"institutions":[260],"different":[262],"or":[264],"implementations":[266],"remains":[267],"questionable.":[268]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}