{"id":"https://openalex.org/W2073077472","doi":"https://doi.org/10.1115/sbc2010-19622","title":"Toward a Functional Tolerance Criterion for the Hippocampus Developed From Organotypic Slice Cultures","display_name":"Toward a Functional Tolerance Criterion for the Hippocampus Developed From Organotypic Slice Cultures","publication_year":2010,"publication_date":"2010-06-16","ids":{"openalex":"https://openalex.org/W2073077472","doi":"https://doi.org/10.1115/sbc2010-19622","mag":"2073077472"},"language":"en","primary_location":{"id":"doi:10.1115/sbc2010-19622","doi":"https://doi.org/10.1115/sbc2010-19622","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2010-19622","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2010 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101633317","display_name":"Zhe Yu","orcid":"https://orcid.org/0000-0002-1401-2294","observed_orcids":["https://orcid.org/0000-0002-1401-2294"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhe Yu","raw_affiliation_strings":["Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021369430","display_name":"Woo Hyeun Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Woo Hyeun Kang","raw_affiliation_strings":["Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019039663","display_name":"Barclay Morrison","orcid":"https://orcid.org/0000-0001-7676-0864","observed_orcids":["https://orcid.org/0000-0001-7676-0864"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barclay Morrison","raw_affiliation_strings":["Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14971874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"401","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11487","display_name":"Automotive and Human Injury Biomechanics","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11487","display_name":"Automotive and Human Injury Biomechanics","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9079999923706055},{"id":"https://openalex.org/keywords/organotypic-slice-cultures","display_name":"organotypic slice cultures","score":0.9599999785423279},{"id":"https://openalex.org/keywords/brain-biomechanics","display_name":"brain biomechanics","score":0.7609999775886536},{"id":"https://openalex.org/keywords/finite-element-model","display_name":"finite element model","score":0.753000020980835},{"id":"https://openalex.org/keywords/brain-deformation","display_name":"brain deformation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/injury-biomechanics","display_name":"injury biomechanics","score":0.7020000219345093},{"id":"https://openalex.org/keywords/head-protection","display_name":"head protection","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.6433078050613403},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.6189061403274536},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.5614094734191895},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5229652523994446},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5228412747383118},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.5068903565406799},{"id":"https://openalex.org/C204366326","wikidata":"https://www.wikidata.org/wiki/Q3027650","display_name":"Deformation (meteorology)","level":2,"score":0.44424429535865784},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44415175914764404},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4300718605518341},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.4155426025390625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36289292573928833},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3587989807128906},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3506739139556885},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.309490442276001},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.28175345063209534},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2137100100517273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1974642276763916},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.15815529227256775},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14324188232421875},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11605742573738098},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0816599428653717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/sbc2010-19622","doi":"https://doi.org/10.1115/sbc2010-19622","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2010-19622","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2010 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2325773629","https://openalex.org/W2082431373","https://openalex.org/W2283662953","https://openalex.org/W2787456842","https://openalex.org/W2556617566","https://openalex.org/W4306318925","https://openalex.org/W2145388503","https://openalex.org/W317025142","https://openalex.org/W4308078205","https://openalex.org/W2606235505"],"abstract_inverted_index":{"Approximately":[0],"1.5":[1],"million":[2],"traumatic":[3],"brain":[4,74,123],"injuries":[5,51],"(TBI)":[6],"occur":[7],"each":[8],"year":[9],"which":[10],"result":[11],"in":[12,95,104],"50,000":[13],"deaths,":[14],"and":[15,115],"about":[16],"80,000":[17],"people":[18],"are":[19],"left":[20],"with":[21,29],"a":[22,69],"permanent":[23],"disability.":[24],"The":[25],"annual":[26],"cost":[27],"associated":[28],"these":[30,50],"injures":[31],"is":[32,40,60],"estimated":[33],"to":[34,48,125],"be":[35,93],"$60":[36],"billion.":[37],"Because":[38],"there":[39],"no":[41],"pharmacological":[42],"treatment":[43],"for":[44,72],"TBI,":[45],"engineering":[46],"strategies":[47,90],"prevent":[49],"enabled":[52],"through":[53],"an":[54],"improved":[55],"understanding":[56],"of":[57,100,121],"injury":[58],"biomechanics":[59],"crucial.":[61],"To":[62],"this":[63],"end,":[64],"finite":[65,108],"element":[66,109],"models":[67,110],"play":[68],"central":[70],"role":[71],"predicting":[73],"deformation":[75],"induced":[76],"by":[77],"various":[78],"loading":[79],"scenarios":[80],"such":[81],"as":[82],"falls":[83],"or":[84],"motor":[85],"vehicle":[86],"accidents.":[87],"Novel":[88],"protection":[89],"can":[91],"then":[92],"tested":[94],"silico":[96],"before":[97],"the":[98,118,122,126],"start":[99],"physical":[101],"testing.":[102],"However,":[103],"their":[105],"current":[106],"form,":[107],"predict":[111,117],"only":[112],"mechanical":[113],"responses":[114],"cannot":[116],"biological":[119],"response":[120],"tissue":[124],"imposed":[127],"deformation.":[128]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}