{"id":"https://openalex.org/W2073056014","doi":"https://doi.org/10.7164/antibiotics.40.165","title":"Actinoidin A2, a novel glycopeptide : Production, preparative HPLC separation and characterization.","display_name":"Actinoidin A2, a novel glycopeptide : Production, preparative HPLC separation and characterization.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2073056014","doi":"https://doi.org/10.7164/antibiotics.40.165","mag":"2073056014","pmid":"https://pubmed.ncbi.nlm.nih.gov/3570965"},"language":"en","primary_location":{"id":"doi:10.7164/antibiotics.40.165","doi":"https://doi.org/10.7164/antibiotics.40.165","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.40.165","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/40/2/40_2_165/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/40/2/40_2_165/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087419854","display_name":"JOHN J. DINGERDISSEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. J. DINGERDISSEN","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067271698","display_name":"Robert D. Sitrin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. D. SITRIN","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016572554","display_name":"Peter DePhillips","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. A. DEPHILLIPS","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008618987","display_name":"Albert J. Giovenella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. J. GIOVENELLA","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022784093","display_name":"Sarah F. Grappel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. F. GRAPPEL","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061740155","display_name":"R. J. MEHTA","orcid":"https://orcid.org/0009-0002-0682-9293","observed_orcids":["https://orcid.org/0009-0002-0682-9293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. J. MEHTA","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078612307","display_name":"Y. K. OH","orcid":"https://orcid.org/0009-0005-3654-4573","observed_orcids":["https://orcid.org/0009-0005-3654-4573"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. K. OH","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110131003","display_name":"C. H. PAN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. H. PAN","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082911039","display_name":"Gerald D. Roberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. D. ROBERTS","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068695481","display_name":"MARCIA C. SHEARER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. C. SHEARER","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064906757","display_name":"L. J. Nisbet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. J. NISBET","raw_affiliation_strings":["Research and Development Division, Smith Kline and French Laboratories","Research and Development Division Smith Kline & French Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Smith Kline and French Laboratories","institution_ids":[]},{"raw_affiliation_string":"Research and Development Division Smith Kline & French Laboratories","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.73,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.612749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"40","issue":"2","first_page":"165","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycopeptide-antibiotics","display_name":"glycopeptides","score":0.9549999833106995},{"id":"https://openalex.org/keywords/nocardia","display_name":"Nocardia","score":0.9120000004768372},{"id":"https://openalex.org/keywords/rhamnose","display_name":"rhamnose","score":0.8920000195503235},{"id":"https://openalex.org/keywords/antibiotic-production","display_name":"antibiotic production","score":0.5690000057220459},{"id":"https://openalex.org/keywords/preparative-hplc","display_name":"preparative HPLC","score":0.722000002861023},{"id":"https://openalex.org/keywords/ion-pair-chromatography","display_name":"ion-pair chromatography","score":0.8450000286102295},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9459999799728394},{"id":"https://openalex.org/keywords/coagulase-negative-staphylococci","display_name":"coagulase-negative staphylococci","score":0.921999990940094},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C137610392","wikidata":"https://www.wikidata.org/wiki/Q2425020","display_name":"Glycopeptide","level":3,"score":0.9560245275497437},{"id":"https://openalex.org/C2779390152","wikidata":"https://www.wikidata.org/wiki/Q2293474","display_name":"Glycopeptide antibiotic","level":5,"score":0.750011682510376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6356157064437866},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6284360885620117},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5263789296150208},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.419478178024292},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3525463044643402},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.3249627947807312},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2146834135055542},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.20562845468521118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16132640838623047},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009615","descriptor_name":"Nocardia","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013055","descriptor_name":"Spectrophotometry, Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7164/antibiotics.40.165","doi":"https://doi.org/10.7164/antibiotics.40.165","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.40.165","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/40/2/40_2_165/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},{"id":"pmid:3570965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3570965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antibiotics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7164/antibiotics.40.165","doi":"https://doi.org/10.7164/antibiotics.40.165","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.40.165","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/40/2/40_2_165/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073056014.pdf","grobid_xml":"https://content.openalex.org/works/W2073056014.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W651972104","https://openalex.org/W1967962768","https://openalex.org/W1993027226","https://openalex.org/W2006562967","https://openalex.org/W2023346934","https://openalex.org/W2033573263","https://openalex.org/W2035194273","https://openalex.org/W2042677685","https://openalex.org/W2050021105","https://openalex.org/W2092912963","https://openalex.org/W2172114166","https://openalex.org/W2346147835","https://openalex.org/W2514578468","https://openalex.org/W2519826720","https://openalex.org/W3004448007"],"related_works":["https://openalex.org/W2033573263","https://openalex.org/W2321084156","https://openalex.org/W2325198196","https://openalex.org/W2039272434","https://openalex.org/W2328478999","https://openalex.org/W2511744394","https://openalex.org/W2060628112","https://openalex.org/W2321655762","https://openalex.org/W4407812216","https://openalex.org/W2017183728"],"abstract_inverted_index":{"An":[0],"unidentified":[1],"Nocardia":[2],"sp.":[3],"(SK&F-AAJ-193)":[4],"was":[5,41,57],"isolated":[6,42],"and":[7,13,70],"found":[8],"to":[9],"produce":[10],"actinoidin":[11,21,29,79],"A":[12,30],"a":[14,49],"novel":[15],"analog":[16,40],"which":[17],"we":[18],"have":[19],"named":[20],"A2.":[22],"This":[23,39],"new":[24],"glycopeptide":[25,51],"antibiotic":[26],"differs":[27],"from":[28],"by":[31,48],"the":[32],"presence":[33],"of":[34,37],"rhamnose":[35],"instead":[36],"acosamine.":[38],"using":[43,59],"Dianion":[44],"HP-20":[45],"resin":[46],"followed":[47],"specific":[50],"affinity":[52],"column":[53],"(Affigel-10-D-Ala-D-Ala).":[54],"The":[55],"purification":[56],"accomplished":[58],"preparative":[60],"ion-pairing":[61],"chromatography.":[62],"Actinoidin":[63],"A2":[64],"is":[65,75],"active":[66],"against":[67],"Staphylococcus":[68],"aureus":[69],"coagulase-negative":[71],"Staphylococci":[72],"although":[73],"it":[74],"less":[76],"potent":[77],"than":[78],"A.":[80]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
