{"id":"https://openalex.org/W2073049802","doi":"https://doi.org/10.1111/1471-0528.13261","title":"Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis","display_name":"Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis","publication_year":2015,"publication_date":"2015-01-22","ids":{"openalex":"https://openalex.org/W2073049802","doi":"https://doi.org/10.1111/1471-0528.13261","mag":"2073049802","pmid":"https://pubmed.ncbi.nlm.nih.gov/25612005"},"language":"en","primary_location":{"id":"doi:10.1111/1471-0528.13261","doi":"https://doi.org/10.1111/1471-0528.13261","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1471-0528.13261","pdf_url":null,"source":{"id":"https://openalex.org/S4210173111","display_name":"BJOG An International Journal of Obstetrics & Gynaecology","issn_l":"0306-5456","issn":["0306-5456","1365-215X","1470-0328","1471-0528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJOG: An International Journal of Obstetrics &amp; Gynaecology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067881298","display_name":"Kelli K. Ryckman","orcid":"https://orcid.org/0000-0002-9496-4147","observed_orcids":["https://orcid.org/0000-0002-9496-4147"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"KK Ryckman","raw_affiliation_strings":["Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054735487","display_name":"CN Spracklen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CN Spracklen","raw_affiliation_strings":["Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030277833","display_name":"C.Z.A. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CJ Smith","raw_affiliation_strings":["Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089418361","display_name":"Jennifer G. Robinson","orcid":"https://orcid.org/0000-0002-4432-4352","observed_orcids":["https://orcid.org/0000-0002-4432-4352"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JG Robinson","raw_affiliation_strings":["Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113861653","display_name":"AF Saftlas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AF Saftlas","raw_affiliation_strings":["Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology; University of Iowa College of Public Health; Iowa City IA USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067881298"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":3.1457,"has_fulltext":false,"cited_by_count":408,"citation_normalized_percentile":{"value":0.94465409,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"122","issue":"5","first_page":"643","last_page":"651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/maternal-lipid-levels","display_name":"maternal lipid levels","score":0.859000027179718},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8700000047683716},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9620000123977661},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pregnancy-trimesters","display_name":"pregnancy trimesters","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2779434492","wikidata":"https://www.wikidata.org/wiki/Q126691","display_name":"Gestational diabetes","level":4,"score":0.8319033980369568},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7146284580230713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7106465101242065},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6941935420036316},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6347029805183411},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6293193101882935},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.591488242149353},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5199924111366272},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4744478464126587},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.4247214198112488},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3977634310722351},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.38949912786483765},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3713512420654297},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.22982287406921387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11359629034996033},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011264","descriptor_name":"Pregnancy Trimesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016640","descriptor_name":"Diabetes, Gestational","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016640","descriptor_name":"Diabetes, Gestational","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064887","descriptor_name":"Observational Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/1471-0528.13261","doi":"https://doi.org/10.1111/1471-0528.13261","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1471-0528.13261","pdf_url":null,"source":{"id":"https://openalex.org/S4210173111","display_name":"BJOG An International Journal of Obstetrics & Gynaecology","issn_l":"0306-5456","issn":["0306-5456","1365-215X","1470-0328","1471-0528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJOG: An International Journal of Obstetrics &amp; Gynaecology","raw_type":"journal-article"},{"id":"pmid:25612005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25612005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJOG : an international journal of obstetrics and gynaecology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W71228264","https://openalex.org/W74743096","https://openalex.org/W96945263","https://openalex.org/W126851268","https://openalex.org/W135521082","https://openalex.org/W1269188908","https://openalex.org/W1598142912","https://openalex.org/W1623509337","https://openalex.org/W1930026518","https://openalex.org/W1943158265","https://openalex.org/W1961194507","https://openalex.org/W1970769347","https://openalex.org/W1975660849","https://openalex.org/W1976388697","https://openalex.org/W1979379232","https://openalex.org/W1979423827","https://openalex.org/W1981557497","https://openalex.org/W1989032159","https://openalex.org/W1998173864","https://openalex.org/W1999578743","https://openalex.org/W2008291800","https://openalex.org/W2008542375","https://openalex.org/W2015974859","https://openalex.org/W2017805305","https://openalex.org/W2022976999","https://openalex.org/W2023513736","https://openalex.org/W2029919619","https://openalex.org/W2030391255","https://openalex.org/W2030788811","https://openalex.org/W2032241244","https://openalex.org/W2039742033","https://openalex.org/W2041812209","https://openalex.org/W2049624032","https://openalex.org/W2050614816","https://openalex.org/W2056467965","https://openalex.org/W2060002447","https://openalex.org/W2060336430","https://openalex.org/W2061380344","https://openalex.org/W2065426685","https://openalex.org/W2068070382","https://openalex.org/W2068205190","https://openalex.org/W2068916670","https://openalex.org/W2071993002","https://openalex.org/W2076910133","https://openalex.org/W2082268242","https://openalex.org/W2089843458","https://openalex.org/W2090166556","https://openalex.org/W2091223419","https://openalex.org/W2095285663","https://openalex.org/W2097089354","https://openalex.org/W2108738781","https://openalex.org/W2111129357","https://openalex.org/W2111575448","https://openalex.org/W2111695901","https://openalex.org/W2113769636","https://openalex.org/W2117898453","https://openalex.org/W2118436135","https://openalex.org/W2118584728","https://openalex.org/W2119934592","https://openalex.org/W2121270872","https://openalex.org/W2122861338","https://openalex.org/W2124241049","https://openalex.org/W2128684295","https://openalex.org/W2135994363","https://openalex.org/W2137347569","https://openalex.org/W2147104202","https://openalex.org/W2147116054","https://openalex.org/W2148562700","https://openalex.org/W2152187454","https://openalex.org/W2155326729","https://openalex.org/W2159935783","https://openalex.org/W2162992895","https://openalex.org/W2163957523","https://openalex.org/W2170193843","https://openalex.org/W2171682892","https://openalex.org/W2171919108","https://openalex.org/W2172134641","https://openalex.org/W2183743655","https://openalex.org/W2206314973","https://openalex.org/W2360831483","https://openalex.org/W2399885158","https://openalex.org/W2406925846","https://openalex.org/W2430148575","https://openalex.org/W2437071967","https://openalex.org/W2461082220","https://openalex.org/W2520432709","https://openalex.org/W2612891587","https://openalex.org/W4240986128","https://openalex.org/W4285719527","https://openalex.org/W4297918764","https://openalex.org/W4301356399","https://openalex.org/W6706891291","https://openalex.org/W6718843186"],"related_works":["https://openalex.org/W3156331861","https://openalex.org/W162671463","https://openalex.org/W4412785759","https://openalex.org/W6931607281","https://openalex.org/W4200533208","https://openalex.org/W7002103305","https://openalex.org/W6949309738","https://openalex.org/W2027236475","https://openalex.org/W7222848081","https://openalex.org/W2938411764"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lipid":[1],"levels":[2,114,133,168,213],"during":[3,84],"pregnancy":[4,39,85],"in":[5,86,112,137,158,172,181,207],"women":[6,87,138,173,215,234,239],"with":[7,65,88,139,142,174,177,216,235,238],"gestational":[8],"diabetes":[9],"mellitus":[10],"(GDM)":[11],"have":[12],"been":[13],"extensively":[14],"studied;":[15],"however,":[16],"it":[17],"remains":[18],"unclear":[19],"whether":[20],"dyslipidaemia":[21],"is":[22],"a":[23],"potential":[24],"marker":[25],"of":[26,56,128,165,201,251],"preexisting":[27],"insulin":[28,221,241],"resistance.":[29,222],"OBJECTIVE:":[30],"To":[31],"evaluate":[32],"the":[33,159,182],"relationship":[34],"between":[35,214],"lipid":[36,70,113],"measures":[37],"throughout":[38],"and":[40,47,53,90,107,162,191,218,243],"GDM.":[41],"SEARCH":[42],"STRATEGY:":[43],"We":[44],"searched":[45],"PubMed-MedLine":[46],"SCOPUS":[48],"(inception":[49],"until":[50],"January":[51],"2014)":[52],"reference":[54],"lists":[55],"relevant":[57],"studies.":[58],"SELECTION":[59],"CRITERIA:":[60],"Publications":[61],"describing":[62],"original":[63],"data":[64],"at":[66],"least":[67],"one":[68],"raw":[69],"(total":[71],"cholesterol,":[72],"high-density":[73],"lipoprotein":[74,78],"cholesterol":[75,79,210],"[HDL-C],":[76],"low-density":[77],"[LDL-C],":[80],"or":[81,211],"triglyceride)":[82],"measurement":[83],"GDM":[89,140,145,175,180,217,236],"healthy":[91],"pregnant":[92],"controls":[93],"were":[94,105,134,169,204],"retained.":[95],"DATA":[96],"COLLECTION":[97],"AND":[98],"ANALYSIS:":[99],"Data":[100],"extracted":[101],"from":[102],"60":[103],"studies":[104],"pooled":[106],"weighted":[108],"mean":[109],"difference":[110],"(WMD)":[111],"was":[115,122,156],"calculated":[116],"using":[117],"random":[118],"effects":[119],"models.":[120],"Meta-regression":[121],"also":[123],"performed":[124],"to":[125,189,198],"identify":[126],"sources":[127],"heterogeneity.":[129],"MAIN":[130],"RESULTS:":[131],"Triglyceride":[132],"significantly":[135,170,231],"elevated":[136,232],"compared":[141,176,237],"those":[143,178,219],"without":[144,179,220,240],"(WMD":[146,184,193],"30.9,":[147],"95%":[148,186,195],"confidence":[149],"interval":[150],"[95%":[151],"CI]":[152],"25.4-36.4).":[153],"This":[154],"finding":[155,245],"consistent":[157],"first,":[160],"second":[161,183],"third":[163,192],"trimesters":[164,200,250],"pregnancy.":[166,202,252],"HDL-C":[167],"lower":[171],"-4.6,":[185],"CI":[187,196],"-6.2":[188],"-3.1)":[190],"-4.1,":[194],"-6.5":[197],"-1.7)":[199],"There":[203],"no":[205],"differences":[206],"aggregate":[208],"total":[209],"LDL-C":[212],"AUTHOR'S":[223],"CONCLUSIONS:":[224],"Our":[225],"meta-analysis":[226],"shows":[227],"that":[228],"triglycerides":[229],"are":[230],"among":[233],"resistance":[242],"this":[244],"persists":[246],"across":[247],"all":[248],"three":[249]},"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":41},{"year":2023,"cited_by_count":49},{"year":2022,"cited_by_count":62},{"year":2021,"cited_by_count":53},{"year":2020,"cited_by_count":43},{"year":2019,"cited_by_count":29},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
