{"id":"https://openalex.org/W2073025161","doi":"https://doi.org/10.1038/nature12297","title":"mTORC1 couples immune signals and metabolic programming to establish Treg-cell function","display_name":"mTORC1 couples immune signals and metabolic programming to establish Treg-cell function","publication_year":2013,"publication_date":"2013-06-28","ids":{"openalex":"https://openalex.org/W2073025161","doi":"https://doi.org/10.1038/nature12297","mag":"2073025161","pmid":"https://pubmed.ncbi.nlm.nih.gov/23812589","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3759242"},"language":"en","primary_location":{"id":"doi:10.1038/nature12297","doi":"https://doi.org/10.1038/nature12297","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature12297","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3759242","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069923589","display_name":"Hu Zeng","orcid":"https://orcid.org/0000-0002-9909-7732","observed_orcids":["https://orcid.org/0000-0002-9909-7732"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hu Zeng","raw_affiliation_strings":["Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044659846","display_name":"Kai Yang","orcid":"https://orcid.org/0000-0003-3103-5719","observed_orcids":["https://orcid.org/0000-0003-3103-5719"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Yang","raw_affiliation_strings":["Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051922010","display_name":"Caryn Cloer","orcid":"https://orcid.org/0000-0002-7365-3462","observed_orcids":["https://orcid.org/0000-0002-7365-3462"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caryn Cloer","raw_affiliation_strings":["Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006819204","display_name":"Geoffrey A. M. Neale","orcid":"https://orcid.org/0000-0003-3776-0858","observed_orcids":["https://orcid.org/0000-0003-3776-0858"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Neale","raw_affiliation_strings":["Hartwell Center for Bioinformatics and Biotechnology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hartwell Center for Bioinformatics and Biotechnology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001763360","display_name":"Peter Vogel","orcid":"https://orcid.org/0000-0002-7535-0545","observed_orcids":["https://orcid.org/0000-0002-7535-0545"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Vogel","raw_affiliation_strings":["Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","Department of Pathology, St. Jude Children's Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Pathology, St. Jude Children's Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084831413","display_name":"Hongbo Chi","orcid":"https://orcid.org/0000-0002-9997-2496","observed_orcids":["https://orcid.org/0000-0002-9997-2496"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hongbo Chi","raw_affiliation_strings":["Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Immunology, St Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084831413"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":26.5827,"has_fulltext":false,"cited_by_count":806,"citation_normalized_percentile":{"value":0.99840759,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"499","issue":"7459","first_page":"485","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.953000009059906},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.953000009059906},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.5519999861717224},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.8299999833106995},{"id":"https://openalex.org/keywords/inducible-t-cell-costimulator","display_name":"ICOS","score":1.0},{"id":"https://openalex.org/keywords/raptors","display_name":"raptors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/mtorc2","display_name":"mTORC2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/treg-suppressive-function","display_name":"Treg suppressive function","score":0.8339999914169312},{"id":"https://openalex.org/keywords/treg-homeostasis","display_name":"Treg homeostasis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/treg-proliferation","display_name":"Treg proliferation","score":0.5559999942779541},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.5170000195503235},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.6809999942779541},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.48899999260902405},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.6060000061988831},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.9474669694900513},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7734873294830322},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.6677748560905457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.656030535697937},{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.6468478441238403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5705673694610596},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.5037009119987488},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.474003404378891},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.4606502056121826},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.4292590618133545},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4177808165550232},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41333216428756714},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.4100790023803711},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3565768599510193},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.2996236979961395},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2559291124343872},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08525675535202026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076223","descriptor_name":"Regulatory-Associated Protein of mTOR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008798","descriptor_name":"Mevalonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060889","descriptor_name":"Inducible T-Cell Co-Stimulator Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/nature12297","doi":"https://doi.org/10.1038/nature12297","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature12297","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:23812589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23812589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2884227","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3759242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3759242","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3759242","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.784.1002","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.784.1002","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ce/ff/nihms479705.PMC3759242.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:nat:nature:v:499:y:2013:i:7459:d:10.1038_nature12297","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature12297","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2884227","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3759242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2996286457","display_name":"Metabolic control of regulatory T cell differentiation","funder_award_id":"R21AI094089","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4119411343","display_name":"mTOR signaling in T cell quiescence","funder_award_id":"R01AI101407","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6753361056","display_name":"The MKP-1/p38 axis: coordinating innate and adaptive immunity","funder_award_id":"R01NS064599","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7202269049","display_name":"Sphingosine 1-Phosphate Signaling in Autoimmune Regulation","funder_award_id":"K01AR053573","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W47217405","https://openalex.org/W1589421810","https://openalex.org/W1964010927","https://openalex.org/W1970400427","https://openalex.org/W1976714959","https://openalex.org/W1981904703","https://openalex.org/W1982311631","https://openalex.org/W1989291933","https://openalex.org/W1990295999","https://openalex.org/W1991263620","https://openalex.org/W2000208875","https://openalex.org/W2004629226","https://openalex.org/W2030284768","https://openalex.org/W2037505364","https://openalex.org/W2055309955","https://openalex.org/W2056721231","https://openalex.org/W2061071534","https://openalex.org/W2063261544","https://openalex.org/W2063888187","https://openalex.org/W2106030214","https://openalex.org/W2117614250","https://openalex.org/W2126028507","https://openalex.org/W2127063807","https://openalex.org/W2130410032","https://openalex.org/W2141267203","https://openalex.org/W2141649011","https://openalex.org/W2146409195","https://openalex.org/W2155759076","https://openalex.org/W2159783687","https://openalex.org/W2159987448","https://openalex.org/W2160683795","https://openalex.org/W2169593537"],"related_works":["https://openalex.org/W7098363522","https://openalex.org/W4256468930","https://openalex.org/W1990630128","https://openalex.org/W4249487384","https://openalex.org/W2806380844","https://openalex.org/W2805618319","https://openalex.org/W2181768953","https://openalex.org/W3081490097","https://openalex.org/W2981738056","https://openalex.org/W2529711900"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":40},{"year":2025,"cited_by_count":52},{"year":2024,"cited_by_count":56},{"year":2023,"cited_by_count":52},{"year":2022,"cited_by_count":64},{"year":2021,"cited_by_count":75},{"year":2020,"cited_by_count":83},{"year":2019,"cited_by_count":72},{"year":2018,"cited_by_count":58},{"year":2017,"cited_by_count":69},{"year":2016,"cited_by_count":73},{"year":2015,"cited_by_count":50},{"year":2014,"cited_by_count":51},{"year":2013,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}