{"id":"https://openalex.org/W2072994066","doi":"https://doi.org/10.1073/pnas.95.14.8187","title":"HD mice: A novel mouse mutant with a specific defect in the generation of CD4 + T cells","display_name":"HD mice: A novel mouse mutant with a specific defect in the generation of CD4 + T cells","publication_year":1998,"publication_date":"1998-07-07","ids":{"openalex":"https://openalex.org/W2072994066","doi":"https://doi.org/10.1073/pnas.95.14.8187","mag":"2072994066","pmid":"https://pubmed.ncbi.nlm.nih.gov/9653162","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/20951"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.95.14.8187","doi":"https://doi.org/10.1073/pnas.95.14.8187","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.95.14.8187","pdf_url":"https://pnas.org/doi/full/10.1073/pnas.95.14.8187","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pnas.org/doi/full/10.1073/pnas.95.14.8187","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103335810","display_name":"Vibhuti P. Dav\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vibhuti P. Dave","raw_affiliation_strings":["Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA, 19111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA, 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066485275","display_name":"David Allman","orcid":"https://orcid.org/0000-0001-9345-1502","observed_orcids":["https://orcid.org/0000-0001-9345-1502"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Allman","raw_affiliation_strings":["Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","Fox Chase Cancer Center, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA,","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109437751","display_name":"Robert Keefe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Keefe","raw_affiliation_strings":["Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","Fox Chase Cancer Center, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA,","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103170575","display_name":"Richard R. Hardy","orcid":"https://orcid.org/0000-0002-9809-5583","observed_orcids":["https://orcid.org/0000-0002-9809-5583"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard R. Hardy","raw_affiliation_strings":["Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","Fox Chase Cancer Center, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA,","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051146159","display_name":"Dietmar J. Kappes","orcid":"https://orcid.org/0000-0002-9112-509X","observed_orcids":["https://orcid.org/0000-0002-9112-509X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dietmar J. Kappes","raw_affiliation_strings":["Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","Fox Chase Cancer Center, Philadelphia, PA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA,","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051146159"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":null,"apc_paid":null,"fwci":0.235,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.52849507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"95","issue":"14","first_page":"8187","last_page":"8192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-t-cell-development","display_name":"CD4+ T cell development","score":0.7929999828338623},{"id":"https://openalex.org/keywords/thymus-development","display_name":"thymus development","score":0.8730000257492065},{"id":"https://openalex.org/keywords/mhc-class-ii-restricted-t-cells","display_name":"MHC class II-restricted T cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cd4-gene","display_name":"CD4 gene","score":0.6150000095367432},{"id":"https://openalex.org/keywords/autosomal-recessive-mutation","display_name":"autosomal recessive mutation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cd4-8-thymocytes","display_name":"CD4+8+ thymocytes","score":0.7559999823570251},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.7770000100135803},{"id":"https://openalex.org/keywords/bone-marrow-transfer","display_name":"bone marrow transfer","score":0.7379999756813049},{"id":"https://openalex.org/keywords/mouse-mutants","display_name":"mouse mutants","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7354058623313904},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.6419992446899414},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6343588829040527},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.5293451547622681},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5177980661392212},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.5045801401138306},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4958263337612152},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.4955648183822632},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4839511215686798},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4460080862045288},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4358724355697632},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4127102196216583},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3478674292564392},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32426905632019043},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.19170096516609192},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.13933321833610535}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.95.14.8187","doi":"https://doi.org/10.1073/pnas.95.14.8187","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.95.14.8187","pdf_url":"https://pnas.org/doi/full/10.1073/pnas.95.14.8187","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:20951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/20951","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9653162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9653162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.95.14.8187","doi":"https://doi.org/10.1073/pnas.95.14.8187","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.95.14.8187","pdf_url":"https://pnas.org/doi/full/10.1073/pnas.95.14.8187","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1878659658","display_name":null,"funder_award_id":"CA74620","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3604114759","display_name":null,"funder_award_id":"AI34472","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7760205201","display_name":"FUNCTION OF CD3  DELTA BY GENE TARGETING","funder_award_id":"R29AI034472","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8849952905","display_name":"Role of CD3 Delta in Developing and Mature T Cells","funder_award_id":"R01CA074620","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000027172","display_name":null,"funder_award_id":"CA-06927","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G921727105","display_name":null,"funder_award_id":"CA06927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072994066.pdf","grobid_xml":"https://content.openalex.org/works/W2072994066.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W81274061","https://openalex.org/W1517252174","https://openalex.org/W1571312540","https://openalex.org/W1775928186","https://openalex.org/W1945938648","https://openalex.org/W1963569988","https://openalex.org/W1967663680","https://openalex.org/W1971150396","https://openalex.org/W1976852696","https://openalex.org/W2001300923","https://openalex.org/W2006665853","https://openalex.org/W2009654152","https://openalex.org/W2011010073","https://openalex.org/W2014013930","https://openalex.org/W2015953791","https://openalex.org/W2017037387","https://openalex.org/W2019719404","https://openalex.org/W2022978700","https://openalex.org/W2024538588","https://openalex.org/W2028669354","https://openalex.org/W2030952613","https://openalex.org/W2037901061","https://openalex.org/W2047414652","https://openalex.org/W2048001161","https://openalex.org/W2049387547","https://openalex.org/W2053275476","https://openalex.org/W2055367559","https://openalex.org/W2055671458","https://openalex.org/W2058165278","https://openalex.org/W2060199817","https://openalex.org/W2064336505","https://openalex.org/W2073474757","https://openalex.org/W2074149483","https://openalex.org/W2081085309","https://openalex.org/W2083847717","https://openalex.org/W2093143038","https://openalex.org/W2095408546","https://openalex.org/W2107682649","https://openalex.org/W2143713452","https://openalex.org/W2145161797","https://openalex.org/W2151206902","https://openalex.org/W2156008881"],"related_works":["https://openalex.org/W2114343711","https://openalex.org/W2003468131","https://openalex.org/W2093143038","https://openalex.org/W2608583213","https://openalex.org/W7097872146","https://openalex.org/W4225497990","https://openalex.org/W2010366356","https://openalex.org/W2060199817","https://openalex.org/W2107682649","https://openalex.org/W2045502050"],"abstract_inverted_index":{"We":[0],"have":[1],"identified":[2],"a":[3,43,100],"spontaneous":[4],"mutation":[5,71],"in":[6,46,138,163,171],"mice,":[7,140],"which":[8],"we":[9],"term":[10],"HD":[11,74,94,139],"for":[12,54],"\"helper":[13],"T":[14,27,38,64],"cell":[15],"deficient.\"":[16],"This":[17,151],"mouse":[18,165],"is":[19,52,66,76,96,114,135,152],"distinguished":[20],"by":[21,99],"the":[22,30,57,73,87,93,103,112,119,153,164,173],"virtual":[23],"absence":[24],"of":[25,29,59,86,102,118,131,157],"peripheral":[26],"cells":[28,65,117,134],"CD4(+)8(-)":[31,55],"major":[32],"histocompatibility":[33],"complex":[34],"(MHC)":[35],"class":[36,80,89,143],"II-restricted":[37,144],"helper":[39],"subset":[40],"due":[41],"to":[42,78,116,125,160],"specific":[44],"block":[45],"thymic":[47],"development.":[48],"The":[49,68,129],"developmental":[50],"defect":[51,101,113,156],"selective":[53],"cells;":[56],"maturation":[58],"CD4(-)8(+)":[60],"and":[61,166],"gamma":[62],"delta":[63],"normal.":[67],"autosomal":[69],"recessive":[70],"underlying":[72,176],"phenotype":[75,95],"unrelated":[77],"MHC":[79,88],"II,":[81],"since":[82],"it":[83],"segregates":[84],"independently":[85],"II":[90],"locus.":[91],"Moreover,":[92],"not":[97],"caused":[98],"CD4":[104],"gene.":[105],"Bone":[106],"marrow":[107],"transfer":[108],"experiments":[109],"demonstrate":[110],"that":[111,142],"intrinsic":[115],"hematopoietic":[120],"lineage,":[121],"i.e.,":[122],"most":[123],"likely":[124],"developing":[126],"thymocytes":[127,145],"themselves.":[128],"frequency":[130],"CD4(+)8(low)":[132],"intermediate":[133],"markedly":[136],"increased":[137],"suggesting":[141],"are":[146],"arrested":[147],"at":[148],"this":[149],"stage.":[150],"first":[154],"genetic":[155],"its":[158],"kind":[159],"be":[161],"described":[162],"may":[167],"prove":[168],"highly":[169],"informative":[170],"understanding":[172],"molecular":[174],"pathways":[175],"lineage":[177],"commitment.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}