{"id":"https://openalex.org/W2072986997","doi":"https://doi.org/10.1038/sj.ki.5000206","title":"Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling","display_name":"Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W2072986997","doi":"https://doi.org/10.1038/sj.ki.5000206","mag":"2072986997","pmid":"https://pubmed.ncbi.nlm.nih.gov/16528250"},"language":"en","primary_location":{"id":"doi:10.1038/sj.ki.5000206","doi":"https://doi.org/10.1038/sj.ki.5000206","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.ki.5000206","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1038/sj.ki.5000206","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016906794","display_name":"Tusty\u2010Jiuan Hsieh","orcid":"https://orcid.org/0000-0001-5387-6522","observed_orcids":["https://orcid.org/0000-0001-5387-6522"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210150747","display_name":"H\u00f4tel-Dieu de Montr\u00e9al","ror":"https://ror.org/0468gx405","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4210150747","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"T.-J. Hsieh","raw_affiliation_strings":["Research Centre, Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al-H\u00f4tel-Dieu, Montreal, Quebec, Canada","Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre, Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al-H\u00f4tel-Dieu, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210150747"]},{"raw_affiliation_string":"Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210150747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051447956","display_name":"R. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210150747","display_name":"H\u00f4tel-Dieu de Montr\u00e9al","ror":"https://ror.org/0468gx405","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4210150747","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Chen","raw_affiliation_strings":["Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210150747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101739209","display_name":"Shao\u2010Ling Zhang","orcid":"https://orcid.org/0000-0002-5255-6970","observed_orcids":["https://orcid.org/0000-0002-5255-6970"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210150747","display_name":"H\u00f4tel-Dieu de Montr\u00e9al","ror":"https://ror.org/0468gx405","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4210150747","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S.-L. Zhang","raw_affiliation_strings":["Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210150747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091501689","display_name":"Fangyong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210150747","display_name":"H\u00f4tel-Dieu de Montr\u00e9al","ror":"https://ror.org/0468gx405","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4210150747","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F. Liu","raw_affiliation_strings":["Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210150747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113674931","display_name":"Marie-Luise Brezniceanu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210150747","display_name":"H\u00f4tel-Dieu de Montr\u00e9al","ror":"https://ror.org/0468gx405","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4210150747","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M.-L. Brezniceanu","raw_affiliation_strings":["Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210150747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114028768","display_name":"Catharine I. Whiteside","orcid":"https://orcid.org/0009-0001-2939-6147","observed_orcids":["https://orcid.org/0009-0001-2939-6147"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C.I. Whiteside","raw_affiliation_strings":["Department of Medicine, Mount Sinai Hospital/University Health Network, 600 University Avenue, Lebovic Building, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Mount Sinai Hospital/University Health Network, 600 University Avenue, Lebovic Building, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068756611","display_name":"Ivan George Fantus","orcid":"https://orcid.org/0000-0002-2395-8209","observed_orcids":["https://orcid.org/0000-0002-2395-8209"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"I.G. Fantus","raw_affiliation_strings":["Department of Medicine, Mount Sinai Hospital/University Health Network, 600 University Avenue, Lebovic Building, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Mount Sinai Hospital/University Health Network, 600 University Avenue, Lebovic Building, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049720282","display_name":"Julie R. Ingelfinger","orcid":"https://orcid.org/0000-0001-9039-2703","observed_orcids":["https://orcid.org/0000-0001-9039-2703"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.R. Ingelfinger","raw_affiliation_strings":["Harvard Medical School, Massachusetts General Hospital, Pediatric Nephrology Unit, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Massachusetts General Hospital, Pediatric Nephrology Unit, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025572908","display_name":"Pavel Hamet","orcid":"https://orcid.org/0000-0001-5716-889X","observed_orcids":["https://orcid.org/0000-0001-5716-889X"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210150747","display_name":"H\u00f4tel-Dieu de Montr\u00e9al","ror":"https://ror.org/0468gx405","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4210150747","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P. Hamet","raw_affiliation_strings":["Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210150747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089990846","display_name":"John S.D. Chan","orcid":"https://orcid.org/0000-0002-7137-454X","observed_orcids":["https://orcid.org/0000-0002-7137-454X"]},"institutions":[{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210150747","display_name":"H\u00f4tel-Dieu de Montr\u00e9al","ror":"https://ror.org/0468gx405","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4210150747","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"J.S.D. Chan","raw_affiliation_strings":["Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre-Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), H\u00f4tel Dieu, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210150747"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5089990846"],"corresponding_institution_ids":["https://openalex.org/I4210142730","https://openalex.org/I4210150747"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.5343,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.89095393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"69","issue":"6","first_page":"1005","last_page":"1015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":1.0},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.968999981880188},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.875},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7519999742507935},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9169999957084656},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.984000027179718},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9449999928474426},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.8410000205039978},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5149999856948853},{"id":"https://openalex.org/keywords/tubulointerstitial-injury","display_name":"tubulointerstitial injury","score":0.8169999718666077},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/biobreeding-rat","display_name":"BioBreeding rat","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.9393324851989746},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8642520904541016},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.7333270907402039},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6327602863311768},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.6233202219009399},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5922062993049622},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43922510743141174},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35229969024658203},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3516730070114136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34453001618385315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3381185531616211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1795589029788971},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10938400030136108}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011913","descriptor_name":"Rats, Inbred BB","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064546","descriptor_name":"Protein Kinase C beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.ki.5000206","doi":"https://doi.org/10.1038/sj.ki.5000206","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.ki.5000206","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},{"id":"pmid:16528250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16528250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/sj.ki.5000206","doi":"https://doi.org/10.1038/sj.ki.5000206","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.ki.5000206","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1606509164","display_name":"ROLES OF THE PROXIMAL TUBULE RENIN ANGIOTENSIN SYSTEM","funder_award_id":"R01HL048455","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W85899443","https://openalex.org/W651155538","https://openalex.org/W1503875629","https://openalex.org/W1529592271","https://openalex.org/W1963648288","https://openalex.org/W1966723290","https://openalex.org/W1990606304","https://openalex.org/W1994232119","https://openalex.org/W2000579954","https://openalex.org/W2005431362","https://openalex.org/W2007616702","https://openalex.org/W2008679807","https://openalex.org/W2011409573","https://openalex.org/W2013040954","https://openalex.org/W2027767115","https://openalex.org/W2028788241","https://openalex.org/W2033846110","https://openalex.org/W2038776268","https://openalex.org/W2044437167","https://openalex.org/W2045285578","https://openalex.org/W2045351184","https://openalex.org/W2052209532","https://openalex.org/W2053135187","https://openalex.org/W2056415344","https://openalex.org/W2061202476","https://openalex.org/W2061681775","https://openalex.org/W2070834681","https://openalex.org/W2070932699","https://openalex.org/W2074376162","https://openalex.org/W2077969109","https://openalex.org/W2086999880","https://openalex.org/W2095176024","https://openalex.org/W2107545715","https://openalex.org/W2114882367","https://openalex.org/W2122668255","https://openalex.org/W2127085070","https://openalex.org/W2129185311","https://openalex.org/W2133070723","https://openalex.org/W2140412307","https://openalex.org/W2150835840","https://openalex.org/W2150989762","https://openalex.org/W2152661270","https://openalex.org/W2152812230","https://openalex.org/W2160235244","https://openalex.org/W2160570558","https://openalex.org/W2161793406","https://openalex.org/W2170245801","https://openalex.org/W2189547245","https://openalex.org/W2260288236","https://openalex.org/W2312535477","https://openalex.org/W2418163994","https://openalex.org/W6698733181","https://openalex.org/W6764528280"],"related_works":["https://openalex.org/W2038776268","https://openalex.org/W2027767115","https://openalex.org/W2382667400","https://openalex.org/W2368135258","https://openalex.org/W2150835840","https://openalex.org/W1990819499","https://openalex.org/W2028231217","https://openalex.org/W2391661275","https://openalex.org/W2361969416","https://openalex.org/W2054902503"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}