{"id":"https://openalex.org/W2072986152","doi":"https://doi.org/10.1159/000194533","title":"Site of Airway Obstruction after Rapid Saline Infusion in Healthy Subjects","display_name":"Site of Airway Obstruction after Rapid Saline Infusion in Healthy Subjects","publication_year":2009,"publication_date":"2009-01-15","ids":{"openalex":"https://openalex.org/W2072986152","doi":"https://doi.org/10.1159/000194533","mag":"2072986152","pmid":"https://pubmed.ncbi.nlm.nih.gov/6836194"},"language":"en","primary_location":{"id":"doi:10.1159/000194533","doi":"https://doi.org/10.1159/000194533","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000194533","pdf_url":null,"source":{"id":"https://openalex.org/S121535265","display_name":"Respiration","issn_l":"0025-7931","issn":["0025-7931","1423-0356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060292739","display_name":"Giovanni Rolla","orcid":"https://orcid.org/0000-0001-5997-7172","observed_orcids":["https://orcid.org/0000-0001-5997-7172"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Rolla","raw_affiliation_strings":["Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069606284","display_name":"Caterina B. Bucca","orcid":"https://orcid.org/0000-0002-9941-9236","observed_orcids":["https://orcid.org/0000-0002-9941-9236"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Bucca","raw_affiliation_strings":["Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048041413","display_name":"Salvatore Polizzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Polizzi","raw_affiliation_strings":["Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085155126","display_name":"Osvaldo Giachino","orcid":"https://orcid.org/0000-0002-4419-6813","observed_orcids":["https://orcid.org/0000-0002-4419-6813"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"O. Giachino","raw_affiliation_strings":["Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008129394","display_name":"AW Maina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Maina","raw_affiliation_strings":["Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113528668","display_name":"W Arossa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"W. Arossa","raw_affiliation_strings":["Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":null,"display_name":"S. Spinaci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Spinaci","raw_affiliation_strings":["Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna (Head: Prof. F. Ceres\u00e4), Universit\u00e0 di Torino, Italia","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.23724899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"2","first_page":"90","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.8379999995231628},{"id":"https://openalex.org/keywords/fluid-overload","display_name":"fluid overload","score":0.5529999732971191},{"id":"https://openalex.org/keywords/small-airway-resistance","display_name":"small airway resistance","score":0.902999997138977},{"id":"https://openalex.org/keywords/flow-volume-curve","display_name":"flow-volume curve","score":0.8230000138282776},{"id":"https://openalex.org/keywords/lung-volume","display_name":"lung volume","score":0.6370000243186951},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9386790990829468},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.805641770362854},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5858013033866882},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.5804328918457031},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5469787120819092},{"id":"https://openalex.org/C2778333281","wikidata":"https://www.wikidata.org/wiki/Q4330029","display_name":"Airway obstruction","level":3,"score":0.47927945852279663}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003011","descriptor_name":"Closing Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005540","descriptor_name":"Forced Expiratory Flow Rates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008448","descriptor_name":"Maximal Expiratory Flow Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014797","descriptor_name":"Vital Capacity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000194533","doi":"https://doi.org/10.1159/000194533","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000194533","pdf_url":null,"source":{"id":"https://openalex.org/S121535265","display_name":"Respiration","issn_l":"0025-7931","issn":["0025-7931","1423-0356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"journal-article"},{"id":"pmid:6836194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6836194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration; international review of thoracic diseases","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/28960","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/28960","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2303869050","https://openalex.org/W2109952000","https://openalex.org/W2122893017","https://openalex.org/W2338682454","https://openalex.org/W179720230","https://openalex.org/W2253710897","https://openalex.org/W1975508225","https://openalex.org/W2052878175","https://openalex.org/W2394984947","https://openalex.org/W2090077666"],"abstract_inverted_index":{"Static":[0],"and":[1,9,30,34,54,60],"dynamic":[2],"lung":[3],"volumes,":[4],"flow-volume":[5],"curve":[6],"in":[7,15,64],"air":[8],"after":[10,21,81,104],"He-O2":[11,72,88],"were":[12,62],"carried":[13],"out":[14],"5":[16],"normal":[17,28],"subjects":[18],"baseline,":[19],"immediately":[20],"rapid":[22,82],"infusion":[23],"of":[24,27,41,47,57,77],"2":[25],"litres":[26],"saline,":[29],"then":[31],"15,":[32],"30":[33,102],"60":[35],"min":[36,103],"after.":[37],"At":[38],"the":[39,42,66,85,105],"end":[40],"infusion,":[43],"a":[44,74],"marked":[45],"reduction":[46],"delta":[48],"MEF50,":[49,52],"FVC,":[50],"FEV1,":[51],"MEF25":[53],"an":[55,96],"increase":[56,76],"Viso":[58],"V":[59],"CV/VC":[61,98],"observed":[63],"all":[65],"subjects.":[67],"The":[68],"poor":[69],"response":[70],"to":[71,92],"suggests":[73],"predominant":[75],"small":[78],"airway":[79],"resistance":[80],"infusion.":[83,106],"In":[84],"recovery":[86],"phase,":[87],"tests":[89],"promptly":[90],"returned":[91],"control":[93],"values,":[94],"while":[95],"increased":[97],"was":[99],"detectable":[100],"until":[101]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}