{"id":"https://openalex.org/W2072965378","doi":"https://doi.org/10.1114/1.1366671","title":"Modeling of Early Events in T Cell Signal Transduction after Controlled T Cell Activation by Peptide Major Histocompatibility Complex","display_name":"Modeling of Early Events in T Cell Signal Transduction after Controlled T Cell Activation by Peptide Major Histocompatibility Complex","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2072965378","doi":"https://doi.org/10.1114/1.1366671","mag":"2072965378","pmid":"https://pubmed.ncbi.nlm.nih.gov/11400719"},"language":"en","primary_location":{"id":"doi:10.1114/1.1366671","doi":"https://doi.org/10.1114/1.1366671","is_oa":false,"landing_page_url":"https://doi.org/10.1114/1.1366671","pdf_url":null,"source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023578757","display_name":"Sungpyo Kim","orcid":"https://orcid.org/0000-0002-6648-2984","observed_orcids":["https://orcid.org/0000-0002-6648-2984"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Kim","raw_affiliation_strings":["Department of Chemical Engineering and Applied Chemistry, Columbia University, New York, NY 10027, USA","Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Applied Chemistry, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. M. Patrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. Patrick","raw_affiliation_strings":["Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York, NY, 10027","Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York, NY, 10027","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012598657","display_name":"Ned S. Braunstein","orcid":"https://orcid.org/0009-0005-2463-3034","observed_orcids":["https://orcid.org/0009-0005-2463-3034"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. S. Braunstein","raw_affiliation_strings":["Department of Medicine, Columbia University, New York, NY, 10032","Department of Medicine, Columbia University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Columbia University, New York, NY, 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Medicine, Columbia University, New York","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. L. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. L. Thomas","raw_affiliation_strings":["Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York, NY, 10027","Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York, NY, 10027","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008427380","display_name":"Edward F. Leonard","orcid":"https://orcid.org/0000-0001-8860-8536","observed_orcids":["https://orcid.org/0000-0001-8860-8536"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. F. Leonard","raw_affiliation_strings":["Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York, NY, 10027","Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York, NY, 10027","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Departments of Chemical Engineering and Applied Chemistry, Columbia University, New York,","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.4709,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.60963944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"29","issue":"5","first_page":"373","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.08540000021457672,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-signaling","display_name":"T cell signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8220000267028809},{"id":"https://openalex.org/keywords/t-cell-receptor-activation","display_name":"T cell receptor stimulation","score":0.722000002861023},{"id":"https://openalex.org/keywords/peptide-mhc-class-ii-complexes","display_name":"peptide-MHC class II complexes","score":0.7689999938011169},{"id":"https://openalex.org/keywords/phospholipase-c-gamma1","display_name":"phospholipase C-gamma1","score":0.7649999856948853},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.8169999718666077},{"id":"https://openalex.org/keywords/er-calcium-release","display_name":"endoplasmic reticulum calcium release","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.5659999847412109},{"id":"https://openalex.org/keywords/fura-2","display_name":"fura-2","score":0.6710000038146973},{"id":"https://openalex.org/keywords/intracellular-calcium-dynamics","display_name":"intracellular calcium dynamics","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cell-to-cell-variability","display_name":"cell-to-cell variability","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.683324933052063},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6096886992454529},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.5941962599754333},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5179440379142761},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5053966045379639},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.4988746643066406},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4927847683429718},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.48166191577911377},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47881895303726196},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4769231975078583},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46542495489120483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45558226108551025},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.4489339590072632},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41751545667648315},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4046703279018402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3316653370857239},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2820577025413513},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21991166472434998},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.19502797722816467},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10326313972473145},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001698","descriptor_name":"Biomedical Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051966","descriptor_name":"Phospholipase C gamma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1114/1.1366671","doi":"https://doi.org/10.1114/1.1366671","is_oa":false,"landing_page_url":"https://doi.org/10.1114/1.1366671","pdf_url":null,"source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:11400719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11400719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of biomedical engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.41999998688697815}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1518314271","https://openalex.org/W1531469735","https://openalex.org/W1538720263","https://openalex.org/W1545383778","https://openalex.org/W1775312787","https://openalex.org/W1971572356","https://openalex.org/W1975807928","https://openalex.org/W1980754944","https://openalex.org/W1994841263","https://openalex.org/W1999436383","https://openalex.org/W2004106131","https://openalex.org/W2007305532","https://openalex.org/W2027671672","https://openalex.org/W2038670191","https://openalex.org/W2049445388","https://openalex.org/W2058548126","https://openalex.org/W2059741122","https://openalex.org/W2062097895","https://openalex.org/W2064888792","https://openalex.org/W2071423255","https://openalex.org/W2073263421","https://openalex.org/W2076171916","https://openalex.org/W2078494443","https://openalex.org/W2088988616","https://openalex.org/W2092643850","https://openalex.org/W2111696845","https://openalex.org/W2119879881","https://openalex.org/W2138259609","https://openalex.org/W2141260882","https://openalex.org/W2144711633"],"related_works":["https://openalex.org/W2119879881","https://openalex.org/W2016397692","https://openalex.org/W2553644296","https://openalex.org/W2230084105","https://openalex.org/W2069857373","https://openalex.org/W2109495864","https://openalex.org/W1573672011","https://openalex.org/W7096934582","https://openalex.org/W2033044947","https://openalex.org/W2934959970"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
