{"id":"https://openalex.org/W2072898309","doi":"https://doi.org/10.1124/jpet.110.177824","title":"Proteasome Regulator Marizomib (NPI-0052) Exhibits Prolonged Inhibition, Attenuated Efflux, and Greater Cytotoxicity than Its Reversible Analogs","display_name":"Proteasome Regulator Marizomib (NPI-0052) Exhibits Prolonged Inhibition, Attenuated Efflux, and Greater Cytotoxicity than Its Reversible Analogs","publication_year":2011,"publication_date":"2011-02-09","ids":{"openalex":"https://openalex.org/W2072898309","doi":"https://doi.org/10.1124/jpet.110.177824","mag":"2072898309","pmid":"https://pubmed.ncbi.nlm.nih.gov/21303921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3083100"},"language":"en","primary_location":{"id":"doi:10.1124/jpet.110.177824","doi":"https://doi.org/10.1124/jpet.110.177824","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.110.177824","pdf_url":"https://jpet.aspetjournals.org/content/jpet/337/2/479.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jpet.aspetjournals.org/content/jpet/337/2/479.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035777518","display_name":"Amanda Obaidat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Obaidat","raw_affiliation_strings":["Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jeffrey Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Weiss","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091208969","display_name":"Brett T Wahlgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Wahlgren","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037466483","display_name":"Rama Rao Manam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rama R. Manam","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018013388","display_name":"Venkat R. Macherla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkat R. Macherla","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025115296","display_name":"Katherine McArthur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine McArthur","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004135764","display_name":"Ta\u2010Hsiang Chao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ta-Hsiang Chao","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000260833","display_name":"Michael A. Palladino","orcid":"https://orcid.org/0000-0002-4687-7612","observed_orcids":["https://orcid.org/0000-0002-4687-7612"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Palladino","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110212659","display_name":"George Kenneth Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Kenneth Lloyd","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083370321","display_name":"Barbara C. M. Potts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara C. Potts","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109572909","display_name":"S.J. Enna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salvatore J. Enna","raw_affiliation_strings":[") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","Departments of Pharmacology, Toxicology, and Therapeutics (A","University of Kansas Cancer Center, Kansas City, Kansas ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":") and Molecular and Integrative Physiology (S.J.E.), University of Kansas Medical Center, Kansas City, Kansas;","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Pharmacol-ogy, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A","institution_ids":[]},{"raw_affiliation_string":"University of Kansas Cancer Center, Kansas City, Kansas (","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006028057","display_name":"Saskia Neuteboom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saskia T.C. Neuteboom","raw_affiliation_strings":["Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","Nereus Pharmaceuticals, Inc. , San Diego , California",".H.); and Nereus Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":"Nereus Pharmaceuticals, Inc. , San Diego , California","institution_ids":[]},{"raw_affiliation_string":".H.); and Nereus Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073680043","display_name":"Bruno Hagenbuch","orcid":"https://orcid.org/0000-0002-2938-8630","observed_orcids":["https://orcid.org/0000-0002-2938-8630"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruno Hagenbuch","raw_affiliation_strings":["Department of Pharmacol- ogy, Toxicology, and Therapeutics , University of Kansas Medical Center , 3901 Rainbow Blvd. , Kansas City , KS 66160 ","Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )",".H.); and Nereus Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacol- ogy, Toxicology, and Therapeutics , University of Kansas Medical Center , 3901 Rainbow Blvd. , Kansas City , KS 66160 ","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pharmacology, Toxicology, and Therapeutics (A. O. , )","institution_ids":[]},{"raw_affiliation_string":".H.); and Nereus Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073680043"],"corresponding_institution_ids":["https://openalex.org/I4210128618"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.1935,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.87831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"337","issue":"2","first_page":"479","last_page":"486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marizomib","display_name":"marizomib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/salinosporamide-a","display_name":"salinosporamide A","score":0.9120000004768372},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.902999997138977},{"id":"https://openalex.org/keywords/irreversible-binding","display_name":"irreversible binding","score":0.38600000739097595},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.7429999709129333},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.6919999718666077},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.8769999742507935},{"id":"https://openalex.org/keywords/multidrug-resistance-associated-protein","display_name":"multidrug resistance-associated protein","score":0.8360000252723694},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/carrier-mediated-transport","display_name":"carrier-mediated transport","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.8589737415313721},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6926204562187195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6112181544303894},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5962834358215332},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5634816288948059},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.514877438545227},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4166003167629242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3802596926689148},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37094658613204956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2807261347770691},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21057364344596863},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07292017340660095},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1124/jpet.110.177824","doi":"https://doi.org/10.1124/jpet.110.177824","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.110.177824","pdf_url":"https://jpet.aspetjournals.org/content/jpet/337/2/479.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3083100","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3083100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Pharmacol Exp Ther","raw_type":"Text"},{"id":"pmid:21303921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21303921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacology and experimental therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1124/jpet.110.177824","doi":"https://doi.org/10.1124/jpet.110.177824","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.110.177824","pdf_url":"https://jpet.aspetjournals.org/content/jpet/337/2/479.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1958400685","display_name":null,"funder_award_id":"RR021940","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2850908965","display_name":null,"funder_award_id":"RR021940","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3504584629","display_name":"Nuclear Receptors in Liver Health and Disease","funder_award_id":"P20RR021940","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4686375030","display_name":null,"funder_award_id":"GM077336","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5229489598","display_name":"Molecular Characterization of Hepatic Organic Anion Transporting Polypeptides","funder_award_id":"R01GM077336","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6278090985","display_name":"Training Program in Environmental Toxicology","funder_award_id":"T32ES007079","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000099149","display_name":null,"funder_award_id":"RR021940","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072898309.pdf","grobid_xml":"https://content.openalex.org/works/W2072898309.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1977348505","https://openalex.org/W1977824021","https://openalex.org/W1977839873","https://openalex.org/W1987583882","https://openalex.org/W2011163336","https://openalex.org/W2012459279","https://openalex.org/W2058717808","https://openalex.org/W2061036730","https://openalex.org/W2063533508","https://openalex.org/W2067653691","https://openalex.org/W2069992059","https://openalex.org/W2079959886","https://openalex.org/W2087067683","https://openalex.org/W2091475892","https://openalex.org/W2106906885","https://openalex.org/W2123077018","https://openalex.org/W2143938165","https://openalex.org/W2148058489","https://openalex.org/W2171513236","https://openalex.org/W2175936755","https://openalex.org/W2288573335","https://openalex.org/W4255738047"],"related_works":["https://openalex.org/W1595109869","https://openalex.org/W2087606900","https://openalex.org/W2242426894","https://openalex.org/W2332247121","https://openalex.org/W2590362343","https://openalex.org/W2168172745","https://openalex.org/W2111567736","https://openalex.org/W2567688800","https://openalex.org/W2053970243","https://openalex.org/W2774314791"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}