{"id":"https://openalex.org/W2072881655","doi":"https://doi.org/10.1118/1.1998312","title":"MO\u2010E\u2010T\u20106E\u201001: Outcome Prediction Models in Radiotherapy: Methods for Improvement and Future Uses","display_name":"MO\u2010E\u2010T\u20106E\u201001: Outcome Prediction Models in Radiotherapy: Methods for Improvement and Future Uses","publication_year":2005,"publication_date":"2005-05-26","ids":{"openalex":"https://openalex.org/W2072881655","doi":"https://doi.org/10.1118/1.1998312","mag":"2072881655"},"language":"en","primary_location":{"id":"doi:10.1118/1.1998312","doi":"https://doi.org/10.1118/1.1998312","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.1998312","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026159944","display_name":"Joseph O. Deasy","orcid":"https://orcid.org/0000-0002-9437-266X","observed_orcids":["https://orcid.org/0000-0002-9437-266X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J Deasy","raw_affiliation_strings":["Washington Univ, Saint Louis, MO","Washington University, Saint Louis,\u00a0MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington Univ, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington University, Saint Louis,\u00a0MO","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026159944"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2658137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"6Part15","first_page":"2072","last_page":"2072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/outcome-prediction-model","display_name":"outcome prediction model","score":0.7789999842643738},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/normal-tissue-complication-probability","display_name":"normal tissue complication probability","score":0.8080000281333923},{"id":"https://openalex.org/keywords/dose-volume-histograms","display_name":"dose-volume histograms","score":0.9350000023841858},{"id":"https://openalex.org/keywords/volume-effect","display_name":"volume effect","score":0.7279999852180481},{"id":"https://openalex.org/keywords/dose-response-modeling","display_name":"dose-response modeling","score":0.7059999704360962},{"id":"https://openalex.org/keywords/3d-treatment-planning","display_name":"3D treatment planning","score":0.8180000185966492},{"id":"https://openalex.org/keywords/threshold-dose","display_name":"threshold dose","score":0.3160000145435333},{"id":"https://openalex.org/keywords/clinical-risk-factors","display_name":"clinical risk factors","score":0.5950000286102295},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7979999780654907},{"id":"https://openalex.org/keywords/normal-tissue-tolerance","display_name":"normal tissue tolerance","score":0.39100000262260437},{"id":"https://openalex.org/keywords/spatial-dose-distribution","display_name":"spatial dose distribution","score":0.46799999475479126},{"id":"https://openalex.org/keywords/parotid-gland","display_name":"parotid gland","score":0.5740000009536743},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.699999988079071},{"id":"https://openalex.org/keywords/rectum","display_name":"rectum","score":0.7080000042915344},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.3970000147819519},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7689999938011169},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.6460000276565552},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.7429999709129333},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.4580000042915344},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.5410000085830688},{"id":"https://openalex.org/keywords/gene-expression-biomarkers","display_name":"gene expression biomarkers","score":0.6399999856948853},{"id":"https://openalex.org/keywords/imaging-biomarkers","display_name":"imaging biomarkers","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7197946310043335},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.6738002300262451},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.5749714374542236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5678041577339172},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5339191555976868},{"id":"https://openalex.org/C2780198649","wikidata":"https://www.wikidata.org/wiki/Q5299249","display_name":"Dose-volume histogram","level":4,"score":0.5278886556625366},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.523097038269043},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.5043169260025024},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.4858505427837372},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.48520663380622864},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32189470529556274},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1118/1.1998312","doi":"https://doi.org/10.1118/1.1998312","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.1998312","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2909390445","https://openalex.org/W2004491756","https://openalex.org/W2052235127","https://openalex.org/W2088986847","https://openalex.org/W2056019999","https://openalex.org/W2040181951","https://openalex.org/W1977127021","https://openalex.org/W1968896057","https://openalex.org/W1978855445","https://openalex.org/W2885005555"],"abstract_inverted_index":{"Historically,":[0],"the":[1,31,35,62,67,87,108,131,137,151,162,175,204,220,248,300,337,344,357,365,372,389,408,420],"ability":[2,255],"to":[3,8,24,45,55,78,129,150,160,173,188,203,237,346,386,392],"predict":[4],"a":[5,9,20,25,83,104,207,210],"patient's":[6,21],"outcome":[7],"course":[10],"of":[11,19,34,89,153,165,290,303,339,359,375,422],"radiation":[12],"therapy":[13,27],"has":[14,69,112],"been":[15,70,113],"very":[16],"limited.":[17],"Knowledge":[18],"likely":[22],"response":[23,40,265,291],"given":[26,206],"was":[28],"quantified":[29,57],"by":[30,82,279],"maximum":[32],"slope":[33],"sigmoidally\u2010shaped":[36],"patient":[37,360],"population":[38],"dose":[39,49,59,80,176,208,250],"curve:":[41],"steep":[42],"slopes":[43,53],"correspond":[44,54],"precisely":[46],"known":[47],"individual":[48,58],"thresholds,":[50],"whereas":[51],"shallow":[52],"poorly":[56],"thresholds.":[60],"In":[61,157,230,240,331],"3\u2010D":[63,154,305],"treatment":[64,155,306,412],"planning":[65,413],"era,":[66],"situation":[68],"fundamentally":[71],"altered:":[72],"it":[73],"is":[74,235,245,256],"no":[75],"longer":[76],"adequate":[77],"characterize":[79],"distributions":[81],"single":[84],"number,":[85],"as":[86,309,327],"effect":[88],"any":[90],"distribution,":[91],"especially":[92],"on":[93,107,313,415],"normal":[94],"tissues":[95],"which":[96,178,286],"are":[97,171,296,311],"often":[98],"non\u2010uniformly":[99],"irradiated,":[100],"may":[101],"depend":[102],"in":[103,134,136,196,351,382],"complex":[105],"way":[106],"spatial":[109],"distribution.":[110],"It":[111],"recognized":[114],"for":[115,348,367],"more":[116,145],"than":[117],"60":[118],"years":[119],"that":[120],"irradiated":[121,166],"organ":[122,185,233,238],"volume":[123,205],"can":[124,432],"dramatically":[125],"affect":[126],"response.":[127],"Efforts":[128],"quantify":[130],"\u2018volume\u2010effect\u2019":[132],"began":[133],"earnest":[135],"late":[138],"1980's,":[139],"but":[140],"have":[141],"recently":[142],"gained":[143],"much":[144],"momentum":[146],"and":[147,227,272,284,361,371,398,429],"effectiveness":[148],"due":[149],"advent":[152],"planning.":[156],"most":[158,179,184],"investigations":[159],"date,":[161],"dose\u2010volume":[163],"histograms":[164],"organs":[167,218],"or":[168,251,379],"tissue":[169],"structures":[170],"analyzed":[172],"determine":[174],"parameters":[177],"correlate":[180],"with":[181,247,388,425],"outcome.":[182],"Remarkably,":[183],"responses":[186],"appear":[187],"fall":[189],"(very":[190],"roughly)":[191],"into":[192],"just":[193],"two":[194],"categories:":[195],"Group":[197,241],"I,":[198],"complication":[199,243,427],"risks":[200],"rise":[201],"according":[202],"above":[209],"relatively":[211,261],"high\u2010dose":[212],"threshold":[213],"(typically":[214],"50\u201360":[215],"Gy).":[216],"These":[217],"include":[219],"spinal":[221],"cord,":[222],"brain":[223],"stem":[224],"esophagus,":[225],"rectum,":[226],"small":[228],"bowel.":[229],"this":[231,288,332],"group,":[232],"function":[234],"related":[236],"structure.":[239],"II,":[242],"risk":[244,324,363],"correlated":[246],"mean":[249],"something":[252],"similar;":[253],"functional":[254,352],"partially":[257],"impaired":[258],"even":[259],"at":[260],"low":[262],"doses.":[263],"This":[264],"group":[266],"includes":[267],"parotid":[268],"glands,":[269],"brain,":[270],"liver,":[271],"lung.":[273],"Simplified":[274],"dose\u2010response":[275],"models":[276,417],"were":[277],"developed":[278],"Kutcher,":[280],"Burman,":[281],"Brahme,":[282],"Niemierko":[283],"others":[285],"reflected":[287],"range":[289],"behavior.":[292],"However,":[293],"those":[294],"analyses":[295],"far":[297],"from":[298,435],"utilizing":[299],"full":[301],"potential":[302,322,349],"image\u2010based":[304],"planning,":[307],"based":[308,414],"they":[310,319],"only":[312],"cumulative":[314],"dose\u2010volume\u2010histogram":[315],"(DVH)":[316],"data.":[317],"Moreover,":[318],"ignore":[320],"other":[321,376],"clinical":[323],"factors,":[325,364],"such":[326],"diabetes,":[328],"age,":[329],"etc.":[330],"talk":[333],"we":[334,405,431],"will":[335,401,406],"estimate":[336],"trajectory":[338],"evolving":[340],"dose\u2010volume\u2010outcomes":[341],"models,":[342],"including":[343],"need":[345,366,391],"search":[347],"variations":[350],"sensitivity":[353],"vs.":[354],"anatomical":[355],"location,":[356],"inclusion":[358],"disease":[362],"advanced":[368],"modeling":[369],"techniques,":[370],"future":[373],"use":[374],"biomarkers":[377],"(imaging":[378],"gene":[380],"analysis\u2010based)":[381],"combined":[383],"models.":[384],"Methods":[385],"deal":[387],"crucial":[390],"accelerate":[393],"inter\u2010institutional":[394],"data":[395],"collection,":[396],"modeling,":[397],"public":[399],"archiving":[400],"be":[402],"discussed.":[403],"Lastly,":[404],"discuss":[407],"inevitable":[409],"move":[410],"towards":[411],"outcomes":[416],"(e.g.,":[418],"maximizing":[419],"probability":[421],"tumor":[423],"control":[424],"acceptable":[426],"risks),":[428],"how":[430],"get":[433],"there":[434],"here.":[436]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
