{"id":"https://openalex.org/W2072802467","doi":"https://doi.org/10.1002/ijc.24606","title":"Activity of tyrosine kinase inhibitor Dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model","display_name":"Activity of tyrosine kinase inhibitor Dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model","publication_year":2009,"publication_date":"2009-05-28","ids":{"openalex":"https://openalex.org/W2072802467","doi":"https://doi.org/10.1002/ijc.24606","mag":"2072802467","pmid":"https://pubmed.ncbi.nlm.nih.gov/19623650"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.24606","doi":"https://doi.org/10.1002/ijc.24606","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24606","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24606","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24606","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047330898","display_name":"Roberta Vitali","orcid":"https://orcid.org/0000-0003-4203-0163","observed_orcids":["https://orcid.org/0000-0003-4203-0163"]},"institutions":[{"id":"https://openalex.org/I110120368","display_name":"National Agency for New Technologies, Energy and Sustainable Economic Development","ror":"https://ror.org/02an8es95","country_code":"IT","type":"government","lineage":["https://openalex.org/I110120368"]},{"id":"https://openalex.org/I4387154131","display_name":"ENEA Casaccia Research Centre","ror":"https://ror.org/02khqd465","country_code":null,"type":"government","lineage":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Vitali","raw_affiliation_strings":["Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy","institution_ids":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082274028","display_name":"Camillo Mancini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110120368","display_name":"National Agency for New Technologies, Energy and Sustainable Economic Development","ror":"https://ror.org/02an8es95","country_code":"IT","type":"government","lineage":["https://openalex.org/I110120368"]},{"id":"https://openalex.org/I4387154131","display_name":"ENEA Casaccia Research Centre","ror":"https://ror.org/02khqd465","country_code":null,"type":"government","lineage":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Camillo Mancini","raw_affiliation_strings":["Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy","institution_ids":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065789463","display_name":"Vincenzo Cesi","orcid":"https://orcid.org/0000-0002-8770-2835","observed_orcids":["https://orcid.org/0000-0002-8770-2835"]},"institutions":[{"id":"https://openalex.org/I110120368","display_name":"National Agency for New Technologies, Energy and Sustainable Economic Development","ror":"https://ror.org/02an8es95","country_code":"IT","type":"government","lineage":["https://openalex.org/I110120368"]},{"id":"https://openalex.org/I4387154131","display_name":"ENEA Casaccia Research Centre","ror":"https://ror.org/02khqd465","country_code":null,"type":"government","lineage":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Cesi","raw_affiliation_strings":["Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy","institution_ids":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025801646","display_name":"Barbara Tanno","orcid":"https://orcid.org/0000-0001-6098-699X","observed_orcids":["https://orcid.org/0000-0001-6098-699X"]},"institutions":[{"id":"https://openalex.org/I110120368","display_name":"National Agency for New Technologies, Energy and Sustainable Economic Development","ror":"https://ror.org/02an8es95","country_code":"IT","type":"government","lineage":["https://openalex.org/I110120368"]},{"id":"https://openalex.org/I4387154131","display_name":"ENEA Casaccia Research Centre","ror":"https://ror.org/02khqd465","country_code":null,"type":"government","lineage":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Tanno","raw_affiliation_strings":["Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy","institution_ids":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072625016","display_name":"Marta Piscitelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110120368","display_name":"National Agency for New Technologies, Energy and Sustainable Economic Development","ror":"https://ror.org/02an8es95","country_code":"IT","type":"government","lineage":["https://openalex.org/I110120368"]},{"id":"https://openalex.org/I4387154131","display_name":"ENEA Casaccia Research Centre","ror":"https://ror.org/02khqd465","country_code":null,"type":"government","lineage":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Piscitelli","raw_affiliation_strings":["Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy","institution_ids":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033913755","display_name":"Mariateresa Mancuso","orcid":"https://orcid.org/0000-0002-0912-9287","observed_orcids":["https://orcid.org/0000-0002-0912-9287"]},"institutions":[{"id":"https://openalex.org/I110120368","display_name":"National Agency for New Technologies, Energy and Sustainable Economic Development","ror":"https://ror.org/02an8es95","country_code":"IT","type":"government","lineage":["https://openalex.org/I110120368"]},{"id":"https://openalex.org/I4387154131","display_name":"ENEA Casaccia Research Centre","ror":"https://ror.org/02khqd465","country_code":null,"type":"government","lineage":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariateresa Mancuso","raw_affiliation_strings":["Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy","institution_ids":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026622024","display_name":"Fabiola Sesti","orcid":"https://orcid.org/0000-0003-4142-1760","observed_orcids":["https://orcid.org/0000-0003-4142-1760"]},"institutions":[{"id":"https://openalex.org/I110120368","display_name":"National Agency for New Technologies, Energy and Sustainable Economic Development","ror":"https://ror.org/02an8es95","country_code":"IT","type":"government","lineage":["https://openalex.org/I110120368"]},{"id":"https://openalex.org/I4387154131","display_name":"ENEA Casaccia Research Centre","ror":"https://ror.org/02khqd465","country_code":null,"type":"government","lineage":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabiola Sesti","raw_affiliation_strings":["Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy","institution_ids":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018350426","display_name":"Emanuela Pasquali","orcid":"https://orcid.org/0000-0002-3997-0659","observed_orcids":["https://orcid.org/0000-0002-3997-0659"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuela Pasquali","raw_affiliation_strings":["Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044243669","display_name":"Bruno Calabretta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruno Calabretta","raw_affiliation_strings":["Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA","Kimmel Cancer Center, Thomas Jefferson University, Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]},{"raw_affiliation_string":"Kimmel Cancer Center, Thomas Jefferson University, Philadelphia PA","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110114231","display_name":"Carlo Dominici","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Carlo Dominici","raw_affiliation_strings":["Department of Pediatrics, Sapienza University, Rome, Italy","Laboratory of Oncology, Bambino Gesu\u0300 Children's Hospital, Rome, Italy","School of Reproductive and Developmental Medicine, Liverpool University, Liverpool, United Kingdom","Laboratory of Oncology, Bambino Ges\u00f9 Children's Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Laboratory of Oncology, Bambino Gesu\u0300 Children's Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]},{"raw_affiliation_string":"School of Reproductive and Developmental Medicine, Liverpool University, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Laboratory of Oncology, Bambino Ges\u00f9 Children's Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056224853","display_name":"Giuseppe Raschell\u00e0","orcid":"https://orcid.org/0000-0002-6070-577X","observed_orcids":["https://orcid.org/0000-0002-6070-577X"]},"institutions":[{"id":"https://openalex.org/I110120368","display_name":"National Agency for New Technologies, Energy and Sustainable Economic Development","ror":"https://ror.org/02an8es95","country_code":"IT","type":"government","lineage":["https://openalex.org/I110120368"]},{"id":"https://openalex.org/I4387154131","display_name":"ENEA Casaccia Research Centre","ror":"https://ror.org/02khqd465","country_code":null,"type":"government","lineage":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giuseppe Raschell\u00e0","raw_affiliation_strings":["","Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Section of Toxicology and Biomedical Sciences, Research Center Casaccia, ENEA, Rome, Italy","institution_ids":["https://openalex.org/I110120368","https://openalex.org/I4387154131"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5056224853"],"corresponding_institution_ids":["https://openalex.org/I110120368","https://openalex.org/I4387154131"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.687,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.84109813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"125","issue":"11","first_page":"2547","last_page":"2555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.824999988079071},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6570000052452087},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8870000243186951},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.8870000243186951},{"id":"https://openalex.org/keywords/orthotopic-mouse-model","display_name":"orthotopic mouse model","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6230000257492065},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.4359999895095825},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.9474651217460632},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5902022123336792},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5714511275291443},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5701960325241089},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5492881536483765},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5130361318588257},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4675922095775604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45294517278671265},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.44640210270881653},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.44035738706588745},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42666661739349365},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.38581863045692444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3327966630458832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29185721278190613},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23476746678352356},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22100013494491577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08609279990196228},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069439","descriptor_name":"Dasatinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069439","descriptor_name":"Dasatinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069439","descriptor_name":"Dasatinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/ijc.24606","doi":"https://doi.org/10.1002/ijc.24606","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24606","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24606","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:19623650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19623650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7184229","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7184229","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Cancer","raw_type":"Text"},{"id":"pmh:oai:iris.unimore.it:11380/640997","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/640997","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/119245","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000271516500008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/ijc.24606","doi":"https://doi.org/10.1002/ijc.24606","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.24606","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.24606","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2060151065","display_name":null,"funder_award_id":"R01 CA95111","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3141656263","display_name":"Transcription Factor Regulation by the BCR/ABL Oncogene","funder_award_id":"R01CA095111","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072802467.pdf"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1583136600","https://openalex.org/W1838901836","https://openalex.org/W1863005346","https://openalex.org/W1970442971","https://openalex.org/W1983116950","https://openalex.org/W1983225862","https://openalex.org/W1986139301","https://openalex.org/W1997679526","https://openalex.org/W2002403140","https://openalex.org/W2007207475","https://openalex.org/W2010750077","https://openalex.org/W2010978319","https://openalex.org/W2035282066","https://openalex.org/W2035930789","https://openalex.org/W2039253480","https://openalex.org/W2044518419","https://openalex.org/W2049734508","https://openalex.org/W2060275730","https://openalex.org/W2065504949","https://openalex.org/W2067606868","https://openalex.org/W2082107683","https://openalex.org/W2090820836","https://openalex.org/W2092606584","https://openalex.org/W2096255810","https://openalex.org/W2103283961","https://openalex.org/W2104908670","https://openalex.org/W2117679740","https://openalex.org/W2122937570","https://openalex.org/W2138216545","https://openalex.org/W2140781632","https://openalex.org/W2150740687","https://openalex.org/W2152420890","https://openalex.org/W2164452916","https://openalex.org/W2165836181","https://openalex.org/W2170700822","https://openalex.org/W4211031423","https://openalex.org/W4231148876"],"related_works":["https://openalex.org/W2143807312","https://openalex.org/W2143974518","https://openalex.org/W4361873059","https://openalex.org/W2059101166","https://openalex.org/W2521199150","https://openalex.org/W2070410089","https://openalex.org/W1560827802","https://openalex.org/W2155615242","https://openalex.org/W1969154832","https://openalex.org/W2514979974"],"abstract_inverted_index":{"Stage":[0],"4":[1],"neuroblastoma":[2],"(NB)":[3],"is":[4],"a":[5],"devastating":[6],"childhood":[7],"cancer":[8],"whose":[9],"poor":[10],"outcome":[11],"has":[12],"remained":[13],"essentially":[14],"unchanged":[15],"in":[16,27,49,54,57,69,73,88,107,123,132,183,218,222,234],"the":[17,28,41,70,119,133,159,188,196,213,227,239],"last":[18],"20":[19],"years.":[20],"Receptor":[21],"tyrosine":[22,45],"kinases":[23],"have":[24],"important":[25],"roles":[26],"control":[29],"of":[30,35,43,75,102,112,121,136,161,191,198,216,229],"proliferation,":[31],"differentiation":[32],"and":[33,56,93,104,114,126,139],"apoptosis":[34],"NB":[36,51],"cells.":[37],"Thus,":[38],"we":[39],"tested":[40,77],"activity":[42],"second-generation":[44],"kinase":[46],"inhibitor":[47],"Dasatinib":[48,62,83,98,122,192,217],"human":[50,240],"cell":[52,64,78],"lines":[53],"vitro":[55,184],"an":[58,67],"orthotopic":[59,224],"mouse":[60],"model.":[61],"inhibited":[63,157],"viability":[65],"with":[66,109,150,176],"IC(50)":[68],"submicromolar":[71],"range":[72],"7":[74,169],"10":[76],"lines.":[79],"In":[80,95,147,173],"sensitive":[81,182],"cells,":[82,97,152],"reduced":[84],"anchorage-independent":[85],"growth":[86,154],"and,":[87],"some":[89],"instances,":[90],"induced":[91],"senescence":[92],"apoptosis.":[94],"HTLA-230":[96,125,151],"treatment":[99,166,205],"caused":[100],"down-regulation":[101],"c-Kit":[103],"c-Src":[105],"phosphorylation":[106],"conjunction":[108],"strong":[110],"inhibition":[111],"Erk1/2":[113],"Akt":[115],"activity.":[116],"To":[117],"test":[118],"efficacy":[120],"vivo,":[124],"SY5Y":[127,177],"cells":[128,178],"were":[129,180],"orthotopically":[130],"injected":[131,149,175],"adrenal":[134],"gland":[135],"nude":[137],"mice":[138,148],"drug":[140],"treatments":[141],"carried":[142],"out":[143],"until":[144],"day":[145,209],"40.":[146],"tumour":[153],"was":[155,167,193,206,220],"significantly":[156],"at":[158,195],"dose":[160,197],"30":[162],"mg/(kg":[163,200],"day)":[164,201],"when":[165,204],"started":[168,207],"days":[170],"after":[171,210],"injection.":[172,211],"animals":[174],"that":[179],"exquisitely":[181],"(IC(50)=":[185],"92":[186],"nM),":[187],"antitumour":[189],"effect":[190,215],"observed":[194],"60":[199],"but":[202],"only":[203],"1":[208],"However,":[212],"anti-tumour":[214],"vivo":[219],"partial":[221],"both":[223],"models,":[225],"emphasizing":[226],"importance":[228],"testing":[230],"candidate":[231],"new":[232],"drugs":[233],"animal":[235],"environments":[236],"closely":[237],"mimicking":[238],"tumour.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-06-24T00:00:00"}