{"id":"https://openalex.org/W2072775166","doi":"https://doi.org/10.1016/0020-711x(80)90204-9","title":"The effect of bleeding and iron administration on the development of hexachlorobenzene-induced rat porphyria","display_name":"The effect of bleeding and iron administration on the development of hexachlorobenzene-induced rat porphyria","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W2072775166","doi":"https://doi.org/10.1016/0020-711x(80)90204-9","mag":"2072775166","pmid":"https://pubmed.ncbi.nlm.nih.gov/7450111"},"language":"en","primary_location":{"id":"doi:10.1016/0020-711x(80)90204-9","doi":"https://doi.org/10.1016/0020-711x(80)90204-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0020-711x(80)90204-9","pdf_url":null,"source":{"id":"https://openalex.org/S116532113","display_name":"International Journal of Biochemistry","issn_l":"0020-711X","issn":["0020-711X","1878-6014"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111523494","display_name":"G. Blekkenhorst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"G.H. Blekkenhorst","raw_affiliation_strings":["UCT/MRC Porphyria Research Unit, Department of Medicine, University of Cape Town Medical School, Observatory 7925, Cape, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCT/MRC Porphyria Research Unit, Department of Medicine, University of Cape Town Medical School, Observatory 7925, Cape, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019259238","display_name":"Robert S. Day","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"R.S. Day","raw_affiliation_strings":["UCT/MRC Porphyria Research Unit, Department of Medicine, University of Cape Town Medical School, Observatory 7925, Cape, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCT/MRC Porphyria Research Unit, Department of Medicine, University of Cape Town Medical School, Observatory 7925, Cape, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016957102","display_name":"Lennox Eales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"L. Eales","raw_affiliation_strings":["UCT/MRC Porphyria Research Unit, Department of Medicine, University of Cape Town Medical School, Observatory 7925, Cape, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCT/MRC Porphyria Research Unit, Department of Medicine, University of Cape Town Medical School, Observatory 7925, Cape, South Africa","institution_ids":["https://openalex.org/I157614274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111523494"],"corresponding_institution_ids":["https://openalex.org/I157614274"],"apc_list":null,"apc_paid":null,"fwci":0.3024,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.47805948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"5-6","first_page":"1013","last_page":"1017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hexachlorobenzene","display_name":"hexachlorobenzene","score":0.9769999980926514},{"id":"https://openalex.org/keywords/porphyria","display_name":"porphyria","score":0.9589999914169312},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.7509999871253967},{"id":"https://openalex.org/keywords/iron-depletion","display_name":"iron depletion","score":0.878000020980835},{"id":"https://openalex.org/keywords/uroporphyrinogen-decarboxylase","display_name":"uroporphyrinogen decarboxylase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/porphyrin-excretion","display_name":"porphyrin excretion","score":0.9200000166893005},{"id":"https://openalex.org/keywords/porphyria-cutanea-tarda","display_name":"porphyria cutanea tarda","score":0.8450000286102295},{"id":"https://openalex.org/keywords/chlorinated-aromatic-compounds","display_name":"chlorinated aromatic compounds","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2779423988","wikidata":"https://www.wikidata.org/wiki/Q409682","display_name":"Hexachlorobenzene","level":3,"score":0.9264024496078491},{"id":"https://openalex.org/C172110603","wikidata":"https://www.wikidata.org/wiki/Q409065","display_name":"Uroporphyrinogen III decarboxylase","level":4,"score":0.8825055360794067},{"id":"https://openalex.org/C2777940757","wikidata":"https://www.wikidata.org/wiki/Q271759","display_name":"Porphyria","level":2,"score":0.8112554550170898},{"id":"https://openalex.org/C2781223928","wikidata":"https://www.wikidata.org/wiki/Q1479497","display_name":"Porphyria cutanea tarda","level":2,"score":0.7502145767211914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6778560280799866},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6405051946640015},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.619932234287262},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.563568651676178},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.4398418068885803},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4336235523223877},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.2709667682647705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26503995060920715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2412070631980896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2280675172805786},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07773858308792114},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C82685317","wikidata":"https://www.wikidata.org/wiki/Q19829510","display_name":"Pollutant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006581","descriptor_name":"Hexachlorobenzene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011164","descriptor_name":"Porphyrias","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011164","descriptor_name":"Porphyrias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011164","descriptor_name":"Porphyrias","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014575","descriptor_name":"Uroporphyrinogen Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0020-711x(80)90204-9","doi":"https://doi.org/10.1016/0020-711x(80)90204-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0020-711x(80)90204-9","pdf_url":null,"source":{"id":"https://openalex.org/S116532113","display_name":"International Journal of Biochemistry","issn_l":"0020-711X","issn":["0020-711X","1878-6014"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:7450111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7450111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W89586193","https://openalex.org/W1775749144","https://openalex.org/W1799145858","https://openalex.org/W1965805948","https://openalex.org/W1991584003","https://openalex.org/W2005905882","https://openalex.org/W2006433745","https://openalex.org/W2037914861","https://openalex.org/W2042652545","https://openalex.org/W2054437946","https://openalex.org/W2063373861","https://openalex.org/W2093175307","https://openalex.org/W2095381063","https://openalex.org/W2189539949","https://openalex.org/W2254790242","https://openalex.org/W2341316186","https://openalex.org/W2412319746","https://openalex.org/W2414870538","https://openalex.org/W2418890389","https://openalex.org/W6603683125","https://openalex.org/W6717137463"],"related_works":["https://openalex.org/W3144634975","https://openalex.org/W1967068807","https://openalex.org/W2092724693","https://openalex.org/W2406203139","https://openalex.org/W2067539215","https://openalex.org/W2579096472","https://openalex.org/W1943047487","https://openalex.org/W2069981188","https://openalex.org/W2341316186","https://openalex.org/W2322963272"],"abstract_inverted_index":null,"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}