{"id":"https://openalex.org/W2072740235","doi":"https://doi.org/10.1111/j.1440-1789.1997.tb00034.x","title":"Immunohistochemical detection of tau protein in various non\u2010human animal brains","display_name":"Immunohistochemical detection of tau protein in various non\u2010human animal brains","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W2072740235","doi":"https://doi.org/10.1111/j.1440-1789.1997.tb00034.x","mag":"2072740235"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1789.1997.tb00034.x","doi":"https://doi.org/10.1111/j.1440-1789.1997.tb00034.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1789.1997.tb00034.x","pdf_url":null,"source":{"id":"https://openalex.org/S43667197","display_name":"Neuropathology","issn_l":"0919-6544","issn":["0919-6544","1440-1789"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109993604","display_name":"Koji Kuroki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koji Kuroki","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113724471","display_name":"Kazuyuki Uchida","orcid":"https://orcid.org/0000-0002-2302-799X","observed_orcids":["https://orcid.org/0000-0002-2302-799X"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyuki Uchida","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022306766","display_name":"Wijit Kiatipattanasakul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wijit Kiatipattanasakul","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102024464","display_name":"Shinichiro Nakamura","orcid":"https://orcid.org/0009-0001-5065-9669","observed_orcids":["https://orcid.org/0009-0001-5065-9669"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin\u2010ichiro Nakamura","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027803959","display_name":"Ryoji Yamaguchi","orcid":"https://orcid.org/0000-0002-8409-8505","observed_orcids":["https://orcid.org/0000-0002-8409-8505"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoji Yamaguchi","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086535576","display_name":"Hiroyuki Nakayama","orcid":"https://orcid.org/0000-0002-2030-9967","observed_orcids":["https://orcid.org/0000-0002-2030-9967"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Nakayama","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111726867","display_name":"Kunio Doi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunio Doi","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111543296","display_name":"Susumu TATEYAMA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Tateyama","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109993604"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.3925,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.64448245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"17","issue":"3","first_page":"174","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9700000286102295},{"id":"https://openalex.org/keywords/canine-brain","display_name":"canine brain","score":0.7670000195503235},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.6159999966621399},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.8299999833106995},{"id":"https://openalex.org/keywords/brainstem-nuclei","display_name":"brainstem nuclei","score":0.527999997138977},{"id":"https://openalex.org/keywords/cross-species-comparison","display_name":"cross-species comparison","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.8072174787521362},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6057008504867554},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5986348390579224},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5279337763786316},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5277881026268005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5274639129638672},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.5064479112625122},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4818659722805023},{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.46796947717666626},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46017682552337646},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35591021180152893},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3073391318321228},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.270773708820343},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.23506689071655273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16074508428573608},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13060125708580017},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/j.1440-1789.1997.tb00034.x","doi":"https://doi.org/10.1111/j.1440-1789.1997.tb00034.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1789.1997.tb00034.x","pdf_url":null,"source":{"id":"https://openalex.org/S43667197","display_name":"Neuropathology","issn_l":"0919-6544","issn":["0919-6544","1440-1789"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropathology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W68962965","https://openalex.org/W857238335","https://openalex.org/W1249061998","https://openalex.org/W1481130297","https://openalex.org/W1598318710","https://openalex.org/W1964927978","https://openalex.org/W1965232330","https://openalex.org/W1967449373","https://openalex.org/W1973774127","https://openalex.org/W1975536340","https://openalex.org/W1979654001","https://openalex.org/W1983184864","https://openalex.org/W1984827962","https://openalex.org/W1987046654","https://openalex.org/W1994030229","https://openalex.org/W1995515835","https://openalex.org/W1998307422","https://openalex.org/W1999421332","https://openalex.org/W1999557812","https://openalex.org/W2005132906","https://openalex.org/W2009267571","https://openalex.org/W2020567257","https://openalex.org/W2027281874","https://openalex.org/W2032009532","https://openalex.org/W2036642860","https://openalex.org/W2036755018","https://openalex.org/W2038823952","https://openalex.org/W2051888833","https://openalex.org/W2053086860","https://openalex.org/W2070971554","https://openalex.org/W2076384868","https://openalex.org/W2088327372","https://openalex.org/W2090601883","https://openalex.org/W2103440561","https://openalex.org/W2119847718","https://openalex.org/W2120803703","https://openalex.org/W2124310598","https://openalex.org/W2134827747","https://openalex.org/W2167241481","https://openalex.org/W2312944212","https://openalex.org/W2317428919","https://openalex.org/W2320022405","https://openalex.org/W2421060135","https://openalex.org/W2441442484"],"related_works":["https://openalex.org/W2040082137","https://openalex.org/W2213083762","https://openalex.org/W2087050159","https://openalex.org/W2007824057","https://openalex.org/W2310428253","https://openalex.org/W2053286101","https://openalex.org/W1999657277","https://openalex.org/W4417477992","https://openalex.org/W2767156463","https://openalex.org/W2066896236"],"abstract_inverted_index":{"In":[0,69],"order":[1],"to":[2,35,45,154],"clarify":[3],"the":[4,51,60,96,114,129,139,158],"tau":[5,42,58,100,151,183],"phosphorylation":[6,152,166],"in":[7,50,62,85,91,120,128,138,157,186,194],"aged":[8,159],"non\u2010human":[9,17,86,107,121,198],"animal":[10,18,87,108,122],"brains,":[11,93],"paraffin":[12],"sections":[13],"of":[14,41,66,79,98,134,149,172],"human":[15,52,92,105,130],"and":[16,38,44,77,106,132,178],"brains":[19,88],"were":[20,117],"examined":[21],"immunohistochemically":[22],"using":[23],"two":[24],"antibodies":[25,73],"against":[26,57],"tau.":[27],"The":[28,142],"monoclonal":[29],"antibody":[30],"(mAb)":[31],"tau\u20102":[32],"is":[33,101,163],"known":[34],"bind":[36],"non\u2010phosphorylated":[37],"phosphorylated":[39],"forms":[40],"protein":[43,61],"recognize":[46],"neurofibrillary":[47],"tangles":[48,111],"(NFT)":[49],"brain,":[53],"whereas":[54],"rabbit":[55],"antiserum":[56],"recognizes":[59],"a":[63,169,180,191],"wide":[64],"variety":[65],"mammalian":[67],"species.":[68],"this":[70],"study,":[71],"both":[72],"recognized":[74],"axons,":[75],"neurites,":[76],"cytoplasm":[78],"neuronal":[80],"cells":[81],"together":[82],"with":[83,196],"oligodendrocytes":[84],"as":[89,179],"reported":[90],"suggesting":[94],"that":[95,165],"distribution":[97],"normal":[99],"quite":[102],"similar":[103],"between":[104],"brains.":[109,123],"Neurofibrillary":[110],"detected":[112],"by":[113],"Gallyas":[115],"method":[116],"not":[118],"found":[119],"Tau\u20102":[124],"intensely":[125],"labeled":[126],"NFT":[127,155],"brain":[131,135],"neurons":[133],"stem":[136],"nuclei":[137],"canine":[140,160],"brain.":[141,161],"results":[143],"may":[144],"suggest":[145],"very":[146],"early":[147],"stage":[148],"abnormal":[150,182],"leading":[153],"formation":[156],"It":[162],"probable":[164],"develops":[167],"over":[168],"long":[170,192],"period":[171],"time":[173],"(more":[174],"than":[175],"25\u201330":[176],"years)":[177],"result":[181],"becomes":[184],"apparent":[185],"humans":[187],"because":[188],"they":[189],"have":[190],"life\u2010span":[193],"comparison":[195],"most":[197],"animals.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}