{"id":"https://openalex.org/W2072697288","doi":"https://doi.org/10.1038/onc.2008.248","title":"The role of PTEN signaling perturbations in cancer and in targeted therapy","display_name":"The role of PTEN signaling perturbations in cancer and in targeted therapy","publication_year":2008,"publication_date":"2008-09-15","ids":{"openalex":"https://openalex.org/W2072697288","doi":"https://doi.org/10.1038/onc.2008.248","mag":"2072697288","pmid":"https://pubmed.ncbi.nlm.nih.gov/18794882"},"language":"en","primary_location":{"id":"doi:10.1038/onc.2008.248","doi":"https://doi.org/10.1038/onc.2008.248","is_oa":false,"landing_page_url":"https://doi.org/10.1038/onc.2008.248","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028116124","display_name":"Megan E. Keniry","orcid":"https://orcid.org/0000-0002-4952-3545","observed_orcids":["https://orcid.org/0000-0002-4952-3545"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Keniry","raw_affiliation_strings":["Department of Pathology, Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, St Nicholas Avenue, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, St Nicholas Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082690187","display_name":"Ramon E. Parsons","orcid":"https://orcid.org/0000-0002-6656-3514","observed_orcids":["https://orcid.org/0000-0002-6656-3514"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R Parsons","raw_affiliation_strings":["Department of Medicine, Columbia University Medical Center, New York, NY, USA","Department of Pathology, Columbia University Medical Center, New York, NY, USA","Department of Pathology, Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, St Nicholas Avenue, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Columbia University Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Pathology, Columbia University Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Department of Pathology, Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, St Nicholas Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082690187"],"corresponding_institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230","https://openalex.org/I78577930"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":2.7826,"has_fulltext":false,"cited_by_count":358,"citation_normalized_percentile":{"value":0.93477812,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"27","issue":"41","first_page":"5477","last_page":"5485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pten-signaling","display_name":"PTEN signaling","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.527999997138977},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/phosphatase","display_name":"phosphatase","score":0.7519999742507935},{"id":"https://openalex.org/keywords/pten-mutation","display_name":"PTEN mutation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.6729999780654907},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9120000004768372},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9649815559387207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.87242591381073},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6456661820411682},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5944585800170898},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.48196765780448914},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.46855196356773376},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.43415015935897827},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43245729804039},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4274539053440094},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4177764058113098},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4115440845489502},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.41126763820648193},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39057210087776184},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3640901446342468},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3015488386154175}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/onc.2008.248","doi":"https://doi.org/10.1038/onc.2008.248","is_oa":false,"landing_page_url":"https://doi.org/10.1038/onc.2008.248","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:18794882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18794882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1162449006","display_name":null,"funder_award_id":"CA082783","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3671888828","display_name":"Molecular Pathogenesis of Basal-like Breast Cancer","funder_award_id":"P01CA097403","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4565908318","display_name":"PTEN Tumor Suppressor and Signal Transduction","funder_award_id":"R01CA082783","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5955157758","display_name":null,"funder_award_id":"CA097403","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306109","display_name":"Avon Foundation for Women","ror":"https://ror.org/02eqe7f55"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":142,"referenced_works":["https://openalex.org/W1489145507","https://openalex.org/W1502422706","https://openalex.org/W1503953068","https://openalex.org/W1514463309","https://openalex.org/W1531960008","https://openalex.org/W1551696649","https://openalex.org/W1565532031","https://openalex.org/W1586476323","https://openalex.org/W1594462831","https://openalex.org/W1637251086","https://openalex.org/W1789958833","https://openalex.org/W1872026285","https://openalex.org/W1908619062","https://openalex.org/W1951189073","https://openalex.org/W1966056568","https://openalex.org/W1969311682","https://openalex.org/W1970893792","https://openalex.org/W1971682693","https://openalex.org/W1973837499","https://openalex.org/W1974530349","https://openalex.org/W1975642651","https://openalex.org/W1976137605","https://openalex.org/W1976385326","https://openalex.org/W1976621036","https://openalex.org/W1978625554","https://openalex.org/W1981188183","https://openalex.org/W1984252209","https://openalex.org/W1984621921","https://openalex.org/W1989488194","https://openalex.org/W1992051089","https://openalex.org/W1994634031","https://openalex.org/W1996695017","https://openalex.org/W1998038367","https://openalex.org/W1999125576","https://openalex.org/W2000954296","https://openalex.org/W2002054992","https://openalex.org/W2006566159","https://openalex.org/W2008167035","https://openalex.org/W2018023891","https://openalex.org/W2018135255","https://openalex.org/W2019017173","https://openalex.org/W2020315034","https://openalex.org/W2020372547","https://openalex.org/W2020416725","https://openalex.org/W2021012077","https://openalex.org/W2021346058","https://openalex.org/W2022416092","https://openalex.org/W2023325850","https://openalex.org/W2023819606","https://openalex.org/W2025851393","https://openalex.org/W2032285280","https://openalex.org/W2033783187","https://openalex.org/W2035008060","https://openalex.org/W2036147050","https://openalex.org/W2036853345","https://openalex.org/W2040362887","https://openalex.org/W2041102071","https://openalex.org/W2041811289","https://openalex.org/W2043806397","https://openalex.org/W2045777034","https://openalex.org/W2047352825","https://openalex.org/W2051023783","https://openalex.org/W2054379164","https://openalex.org/W2056388945","https://openalex.org/W2056579307","https://openalex.org/W2057793681","https://openalex.org/W2058138221","https://openalex.org/W2058733098","https://openalex.org/W2059221693","https://openalex.org/W2059411043","https://openalex.org/W2060387248","https://openalex.org/W2067138633","https://openalex.org/W2067751798","https://openalex.org/W2068345721","https://openalex.org/W2068427129","https://openalex.org/W2069023125","https://openalex.org/W2069232844","https://openalex.org/W2070942270","https://openalex.org/W2071656971","https://openalex.org/W2074473619","https://openalex.org/W2075211183","https://openalex.org/W2075291089","https://openalex.org/W2075920859","https://openalex.org/W2076103389","https://openalex.org/W2078312014","https://openalex.org/W2085483616","https://openalex.org/W2087812126","https://openalex.org/W2089632625","https://openalex.org/W2093628776","https://openalex.org/W2094941511","https://openalex.org/W2095659495","https://openalex.org/W2097767970","https://openalex.org/W2099658407","https://openalex.org/W2100589633","https://openalex.org/W2102563614","https://openalex.org/W2103140083","https://openalex.org/W2104593771","https://openalex.org/W2109263914","https://openalex.org/W2110143939","https://openalex.org/W2112911113","https://openalex.org/W2114725617","https://openalex.org/W2117905749","https://openalex.org/W2117996979","https://openalex.org/W2118182234","https://openalex.org/W2121389354","https://openalex.org/W2122434534","https://openalex.org/W2122522737","https://openalex.org/W2122624068","https://openalex.org/W2125536613","https://openalex.org/W2127757047","https://openalex.org/W2128613144","https://openalex.org/W2129172946","https://openalex.org/W2131234404","https://openalex.org/W2134557279","https://openalex.org/W2135721953","https://openalex.org/W2135838271","https://openalex.org/W2139248766","https://openalex.org/W2142712146","https://openalex.org/W2143270922","https://openalex.org/W2143348495","https://openalex.org/W2145804860","https://openalex.org/W2146157811","https://openalex.org/W2150233389","https://openalex.org/W2152405594","https://openalex.org/W2152654745","https://openalex.org/W2152988906","https://openalex.org/W2154692501","https://openalex.org/W2155737059","https://openalex.org/W2156216950","https://openalex.org/W2159064969","https://openalex.org/W2161810908","https://openalex.org/W2163325084","https://openalex.org/W2163583831","https://openalex.org/W2164837623","https://openalex.org/W2165863663","https://openalex.org/W2168989003","https://openalex.org/W2170296344","https://openalex.org/W2312585383","https://openalex.org/W2316897574","https://openalex.org/W2317331694","https://openalex.org/W2329681473","https://openalex.org/W4238567307"],"related_works":["https://openalex.org/W4206884930","https://openalex.org/W3176093245","https://openalex.org/W3118178227","https://openalex.org/W2077582389","https://openalex.org/W4243930828","https://openalex.org/W2029347765","https://openalex.org/W2773474457","https://openalex.org/W45518098","https://openalex.org/W2017739035","https://openalex.org/W2064220189"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":36}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
