{"id":"https://openalex.org/W2072694293","doi":"https://doi.org/10.1111/j.1365-2982.2008.01242.x","title":"The multi\u2010herbal drug STW 5 (Iberogast\u00ae) has prosecretory action in the human intestine","display_name":"The multi\u2010herbal drug STW 5 (Iberogast\u00ae) has prosecretory action in the human intestine","publication_year":2009,"publication_date":"2009-02-03","ids":{"openalex":"https://openalex.org/W2072694293","doi":"https://doi.org/10.1111/j.1365-2982.2008.01242.x","mag":"2072694293","pmid":"https://pubmed.ncbi.nlm.nih.gov/19210628"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2982.2008.01242.x","doi":"https://doi.org/10.1111/j.1365-2982.2008.01242.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2982.2008.01242.x","pdf_url":null,"source":{"id":"https://openalex.org/S84837402","display_name":"Neurogastroenterology & Motility","issn_l":"1350-1925","issn":["1350-1925","1365-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurogastroenterology & Motility","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088530314","display_name":"Dagmar Krueger","orcid":"https://orcid.org/0000-0003-1950-9547","observed_orcids":["https://orcid.org/0000-0003-1950-9547"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Krueger","raw_affiliation_strings":["Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114163699","display_name":"Lisa Gruber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L. Gruber","raw_affiliation_strings":["Department of Human Biology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060044123","display_name":"Sabine B\u00fchner","orcid":"https://orcid.org/0000-0002-9115-0463","observed_orcids":["https://orcid.org/0000-0002-9115-0463"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Buhner","raw_affiliation_strings":["Department of Human Biology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044827987","display_name":"Florian Zeller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Zeller","raw_affiliation_strings":["Department of Surgery, Clinical Centre Freising, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Clinical Centre Freising, Freising, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091797746","display_name":"Rupert Langer","orcid":"https://orcid.org/0000-0001-9491-3609","observed_orcids":["https://orcid.org/0000-0001-9491-3609"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Langer","raw_affiliation_strings":["Department of Pathology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","Department of Pathology; Technische Universit\u00e4t M\u00fcnchen; M\u00fcnchen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Pathology; Technische Universit\u00e4t M\u00fcnchen; M\u00fcnchen Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071170391","display_name":"Stefan Seidl","orcid":"https://orcid.org/0000-0002-9722-4208","observed_orcids":["https://orcid.org/0000-0002-9722-4208"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Seidl","raw_affiliation_strings":["Department of Pathology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","Department of Pathology; Technische Universit\u00e4t M\u00fcnchen; M\u00fcnchen Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Pathology; Technische Universit\u00e4t M\u00fcnchen; M\u00fcnchen Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028220766","display_name":"Klaus Michel","orcid":"https://orcid.org/0000-0003-2359-6428","observed_orcids":["https://orcid.org/0000-0003-2359-6428"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Michel","raw_affiliation_strings":["Department of Human Biology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044612561","display_name":"Michael Schemann","orcid":"https://orcid.org/0000-0003-1007-9843","observed_orcids":["https://orcid.org/0000-0003-1007-9843","https://orcid.org/0009-0002-4069-2251"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"M. Schemann","raw_affiliation_strings":["Department of Human Biology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, Technische Universita\u0308t Mu\u0308nchen, Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Human Biology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044612561"],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":3.848,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.9213858,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"21","issue":"11","first_page":"1203","last_page":"1203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stw-5","display_name":"STW 5","score":0.9190000295639038},{"id":"https://openalex.org/keywords/iberogast","display_name":"Iberogast","score":0.9980000257492065},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.7580000162124634},{"id":"https://openalex.org/keywords/intestinal-secretion","display_name":"intestinal secretion","score":0.7689999938011169},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9449999928474426},{"id":"https://openalex.org/keywords/functional-dyspepsia","display_name":"functional dyspepsia","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.8980000019073486},{"id":"https://openalex.org/keywords/calcium-activated-chloride-channels","display_name":"calcium-activated chloride channels","score":0.9139999747276306},{"id":"https://openalex.org/keywords/enteric-neurons","display_name":"enteric neurons","score":0.8510000109672546},{"id":"https://openalex.org/keywords/epithelial-ion-transport","display_name":"epithelial ion transport","score":0.6119999885559082},{"id":"https://openalex.org/keywords/t84-cells","display_name":"T84 cells","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bumetanide","display_name":"bumetanide","score":0.6840000152587891},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cftr-inhibitors","display_name":"CFTR inhibitors","score":0.578000009059906},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2779932011","wikidata":"https://www.wikidata.org/wiki/Q581885","display_name":"Ussing chamber","level":3,"score":0.6982239484786987},{"id":"https://openalex.org/C2778212192","wikidata":"https://www.wikidata.org/wiki/Q275926","display_name":"Bumetanide","level":4,"score":0.6765967011451721},{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.6691117286682129},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5390889048576355},{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.46302786469459534},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.45680636167526245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45638707280158997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4547445476055145},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.43856281042099},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.428524374961853},{"id":"https://openalex.org/C188053792","wikidata":"https://www.wikidata.org/wiki/Q3640664","display_name":"Cotransporter","level":3,"score":0.36663803458213806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3252948522567749},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.1331634521484375},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.08137434720993042},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2982.2008.01242.x","doi":"https://doi.org/10.1111/j.1365-2982.2008.01242.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2982.2008.01242.x","pdf_url":null,"source":{"id":"https://openalex.org/S84837402","display_name":"Neurogastroenterology & Motility","issn_l":"1350-1925","issn":["1350-1925","1365-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurogastroenterology & Motility","raw_type":"journal-article"},{"id":"pmid:19210628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19210628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurogastroenterology and motility","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W189133932","https://openalex.org/W1484853386","https://openalex.org/W1491518420","https://openalex.org/W1572397755","https://openalex.org/W1634298261","https://openalex.org/W1917184534","https://openalex.org/W1965194352","https://openalex.org/W1971289338","https://openalex.org/W1976536123","https://openalex.org/W1979853647","https://openalex.org/W1981815916","https://openalex.org/W1985838900","https://openalex.org/W1991824136","https://openalex.org/W1993308285","https://openalex.org/W2018904615","https://openalex.org/W2046838884","https://openalex.org/W2048871701","https://openalex.org/W2063550636","https://openalex.org/W2075295270","https://openalex.org/W2080004121","https://openalex.org/W2087157712","https://openalex.org/W2088892067","https://openalex.org/W2112844885","https://openalex.org/W2142976848","https://openalex.org/W2149512951","https://openalex.org/W2157370454","https://openalex.org/W2163551971","https://openalex.org/W2166717315","https://openalex.org/W2319035760"],"related_works":["https://openalex.org/W2006591072","https://openalex.org/W2568301255","https://openalex.org/W2333345995","https://openalex.org/W2621890873","https://openalex.org/W2641128222","https://openalex.org/W2037220108","https://openalex.org/W1985644412","https://openalex.org/W1845491371","https://openalex.org/W1989934192","https://openalex.org/W2033721038"],"abstract_inverted_index":{"There":[0],"is":[1,36,206,226],"growing":[2],"evidence":[3],"that":[4,31,121,203],"STW":[5,53,94,112,185,188,204,239],"5":[6,54,95,113,186,189,205,240],"(Iberogast),":[7],"fixed":[8],"combination":[9],"of":[10,33,52,155,171,197,220],"hydroethanolic":[11],"herbal":[12],"extracts),":[13],"besides":[14],"being":[15],"effective":[16],"in":[17,23,57,78,84,118,195,209],"functional":[18],"dyspepsia,":[19],"also":[20],"improves":[21],"symptoms":[22],"irritable":[24],"bowel":[25],"syndrome":[26],"(IBS).":[27],"Clinical":[28],"data":[29],"indicate":[30],"modulation":[32],"mucosal":[34,76],"secretion":[35,56,77,120],"a":[37,115,169,207,243],"promising":[38],"approach":[39],"to":[40,74,228,246],"treat":[41,247],"intestinal":[42,80],"disorders":[43,249],"associated":[44,250],"with":[45,101,251],"IBS.":[46],"We":[47],"therefore":[48],"explored":[49],"the":[50,58,62,126,131,137,153,178,184,210],"effect":[51,225],"on":[55,97],"human":[59,79,85,98,107,176,198,211],"intestine":[60,212],"and":[61,83,109,139,149,152,217,235,253],"mechanisms":[63],"by":[64,125,167,213],"which":[65],"it":[66],"acts.":[67],"The":[68,223],"Ussing":[69],"chamber":[70],"technique":[71],"was":[72,122,165],"used":[73],"measure":[75],"mucosa/submucosa":[81],"preparations":[82],"epithelial":[86,172,215,230],"cell":[87],"line":[88],"T84.":[89],"In":[90,106,175],"addition,":[91],"we":[92],"recorded":[93],"effects":[96],"enteric":[99,221],"neurons":[100],"voltage":[102],"sensitive":[103],"dye":[104],"imaging.":[105],"tissue":[108],"T84":[110],"cells":[111],"induced":[114],"dose-dependent":[116],"increase":[117],"ion":[119],"significantly":[123,182],"reduced":[124],"Na-K-Cl":[127],"cotransporter":[128],"blocker":[129,154,170,180],"bumetanide,":[130],"adenylate":[132],"cyclase":[133],"inhibitor":[134],"MDL-12":[135],"330,":[136],"non-specific":[138],"selective":[140],"cystic":[141],"fibrosis":[142],"transmembrane":[143],"conductance":[144],"regulator":[145],"(CFTR)":[146],"inhibitors":[147],"glibenclamide":[148],"CFTR(inh)-172,":[150],"respectively,":[151],"calcium":[156],"dependent":[157],"Cl(-)":[158,231],"channels":[159],"(ClCa)":[160],"SITS":[161],"(4-acetamido-4-isothiocyanatostilbene-2,2-disulphonic":[162],"acid).":[163],"It":[164],"unaffected":[166],"amiloride,":[168],"Na(+)":[173],"channels.":[174,238],"tissue,":[177],"nerve":[179],"tetrodotoxin":[181],"suppressed":[183],"response.":[187],"evoked":[190],"an":[191],"increased":[192,229],"spike":[193],"discharge":[194],"51%":[196],"submucous":[199],"neurons.":[200,222],"Results":[201],"suggest":[202],"secretogogue":[208],"direct":[214],"actions":[216],"through":[218],"activation":[219],"prosecretory":[224],"due":[227],"fluxes":[232],"via":[233],"CFTR":[234],"Ca-dependent":[236],"ClCa":[237],"may":[241],"be":[242],"novel":[244],"option":[245],"secretory":[248],"IBS":[252],"constipation.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}