{"id":"https://openalex.org/W2072676547","doi":"https://doi.org/10.1074/jbc.r700042200","title":"Intracellular Organic Osmolytes: Function and Regulation","display_name":"Intracellular Organic Osmolytes: Function and Regulation","publication_year":2008,"publication_date":"2008-02-07","ids":{"openalex":"https://openalex.org/W2072676547","doi":"https://doi.org/10.1074/jbc.r700042200","mag":"2072676547","pmid":"https://pubmed.ncbi.nlm.nih.gov/18256030","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2276334"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.r700042200","doi":"https://doi.org/10.1074/jbc.r700042200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r700042200","pdf_url":"http://www.jbc.org/article/S002192582055117X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192582055117X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025916093","display_name":"Maurice B. Burg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maurice B. Burg","raw_affiliation_strings":["Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603, USA. Maurice_Burg@nih.gov","Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603, USA. Maurice_Burg@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051074151","display_name":"Joan D. Ferraris","orcid":"https://orcid.org/0000-0003-4696-2347","observed_orcids":["https://orcid.org/0000-0003-4696-2347"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan D. Ferraris","raw_affiliation_strings":["Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025916093"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":15.0174,"has_fulltext":true,"cited_by_count":665,"citation_normalized_percentile":{"value":0.99340369,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"283","issue":"12","first_page":"7309","last_page":"7313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.24300000071525574,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.24300000071525574,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.17299999296665192,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.09449999779462814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organic-osmolytes","display_name":"organic osmolytes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hyperosmolarity","display_name":"hyperosmolarity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.6620000004768372},{"id":"https://openalex.org/keywords/osmolyte-accumulation","display_name":"osmolyte accumulation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.9240000247955322},{"id":"https://openalex.org/keywords/methylamine","display_name":"methylamine","score":0.972000002861023},{"id":"https://openalex.org/keywords/osmoprotection","display_name":"osmoprotection","score":0.6539999842643738},{"id":"https://openalex.org/keywords/archaea","display_name":"archaea","score":0.800000011920929},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.7089999914169312},{"id":"https://openalex.org/keywords/plants","display_name":"plants","score":0.9319999814033508},{"id":"https://openalex.org/keywords/marine-fauna","display_name":"marine fauna","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mammals","display_name":"mammals","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C127160389","wikidata":"https://www.wikidata.org/wiki/Q415608","display_name":"Osmolyte","level":2,"score":0.9965787529945374},{"id":"https://openalex.org/C550995028","wikidata":"https://www.wikidata.org/wiki/Q10872","display_name":"Archaea","level":3,"score":0.8172439932823181},{"id":"https://openalex.org/C26448091","wikidata":"https://www.wikidata.org/wiki/Q176686","display_name":"Osmoprotectant","level":4,"score":0.6777881383895874},{"id":"https://openalex.org/C2910482912","wikidata":"https://www.wikidata.org/wiki/Q409304","display_name":"Methylamines","level":3,"score":0.6732234954833984},{"id":"https://openalex.org/C58415070","wikidata":"https://www.wikidata.org/wiki/Q909456","display_name":"Osmoregulation","level":3,"score":0.5787658095359802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5353748202323914},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.531862199306488},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5064307451248169},{"id":"https://openalex.org/C2910654035","wikidata":"https://www.wikidata.org/wiki/Q1259242","display_name":"Intracellular Fluid","level":3,"score":0.4921931326389313},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.44138965010643005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4107149839401245},{"id":"https://openalex.org/C129513315","wikidata":"https://www.wikidata.org/wiki/Q179615","display_name":"Salinity","level":2,"score":0.21224242448806763},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.19527959823608398},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.16054293513298035},{"id":"https://openalex.org/C2779815552","wikidata":"https://www.wikidata.org/wiki/Q484583","display_name":"Proline","level":3,"score":0.1426330804824829},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001105","descriptor_name":"Archaea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010944","descriptor_name":"Plants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.r700042200","doi":"https://doi.org/10.1074/jbc.r700042200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r700042200","pdf_url":"http://www.jbc.org/article/S002192582055117X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2276334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2276334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:18256030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18256030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.r700042200","doi":"https://doi.org/10.1074/jbc.r700042200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r700042200","pdf_url":"http://www.jbc.org/article/S002192582055117X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072676547.pdf","grobid_xml":"https://content.openalex.org/works/W2072676547.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1494966285","https://openalex.org/W1854506452","https://openalex.org/W1973394750","https://openalex.org/W1985589004","https://openalex.org/W1986115510","https://openalex.org/W1998137862","https://openalex.org/W2007016370","https://openalex.org/W2030625477","https://openalex.org/W2033924510","https://openalex.org/W2047168931","https://openalex.org/W2054670584","https://openalex.org/W2076410226","https://openalex.org/W2076452226","https://openalex.org/W2089336118","https://openalex.org/W2106032649","https://openalex.org/W2106058825","https://openalex.org/W2112225255","https://openalex.org/W2146398795","https://openalex.org/W2148874125","https://openalex.org/W2159100436","https://openalex.org/W2162651138","https://openalex.org/W2182673743","https://openalex.org/W2412330862","https://openalex.org/W2764367733"],"related_works":["https://openalex.org/W2102167129","https://openalex.org/W2102917649","https://openalex.org/W4415466537","https://openalex.org/W2301465920","https://openalex.org/W171232367","https://openalex.org/W1184179188","https://openalex.org/W2135684970","https://openalex.org/W7098160472","https://openalex.org/W2415951527","https://openalex.org/W2614179370"],"abstract_inverted_index":{"Cells":[0],"of":[1,17,36,57],"almost":[2],"all":[3],"organisms":[4],"accumulate":[5],"organic":[6,30],"osmolytes":[7,31,37],"when":[8],"exposed":[9],"to":[10],"hyperosmolality,":[11],"most":[12],"often":[13],"in":[14,38],"the":[15,29,34,48,60],"form":[16],"high":[18],"salt":[19],"or":[20],"urea.":[21],"In":[22],"this":[23],"review,":[24],"we":[25],"discuss":[26],"1)":[27],"how":[28],"protect;":[32],"2)":[33],"identity":[35],"Archaea,":[39],"bacteria,":[40],"yeast,":[41],"plants,":[42],"marine":[43],"animals,":[44],"and":[45,64,70],"mammals;":[46],"3)":[47],"mechanisms":[49],"by":[50,68],"which":[51],"they":[52],"are":[53],"accumulated;":[54],"4)":[55],"sensors":[56],"osmolality;":[58],"5)":[59],"signaling":[61],"pathways":[62],"involved;":[63],"6)":[65],"mutual":[66],"counteraction":[67],"urea":[69],"methylamines.":[71]},"counts_by_year":[{"year":2026,"cited_by_count":33},{"year":2025,"cited_by_count":42},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":32},{"year":2022,"cited_by_count":53},{"year":2021,"cited_by_count":57},{"year":2020,"cited_by_count":66},{"year":2019,"cited_by_count":63},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":45},{"year":2016,"cited_by_count":41},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
