{"id":"https://openalex.org/W2072673741","doi":"https://doi.org/10.1111/j.1749-6632.1992.tb25963.x","title":"Effects of Chronic Ethanol and Benzodiazepine Treatment and Withdrawal on Corticotropin\u2010releasing Factor Neural Systemsa","display_name":"Effects of Chronic Ethanol and Benzodiazepine Treatment and Withdrawal on Corticotropin\u2010releasing Factor Neural Systemsa","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W2072673741","doi":"https://doi.org/10.1111/j.1749-6632.1992.tb25963.x","mag":"2072673741","pmid":"https://pubmed.ncbi.nlm.nih.gov/1632579"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1992.tb25963.x","doi":"https://doi.org/10.1111/j.1749-6632.1992.tb25963.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1992.tb25963.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M. ADRIANA VARGAS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. ADRIANA VARGAS","raw_affiliation_strings":["Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087243297","display_name":"Garth Bissette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GARTH BISSETTE","raw_affiliation_strings":["Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110141218","display_name":"Michael J. Owens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL J. OWENS","raw_affiliation_strings":["Department of Psychiatry Emory University Medical School Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Emory University Medical School Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033673764","display_name":"Cindy L. Ehlers","orcid":"https://orcid.org/0000-0002-2717-994X","observed_orcids":["https://orcid.org/0000-0002-2717-994X"]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CINDY L. EHLERS","raw_affiliation_strings":["Research Institute of the Scripps Clinic, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of the Scripps Clinic, La Jolla, California 92037","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050356892","display_name":"Charles B. Nemeroff","orcid":"https://orcid.org/0000-0001-7867-1160","observed_orcids":["https://orcid.org/0000-0001-7867-1160"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"CHARLES B. NEMEROFF","raw_affiliation_strings":["Department of Psychiatry Emory University Medical School Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Emory University Medical School Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050356892"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.1825,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.30434783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"654","issue":"1","first_page":"145","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-alcohol-exposure","display_name":"chronic ethanol exposure","score":0.7820000052452087},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9580000042915344},{"id":"https://openalex.org/keywords/alcohol-withdrawal-syndrome","display_name":"alcohol withdrawal","score":0.7310000061988831},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neuroendocrine-stress-response","display_name":"neuroendocrine stress response","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2778037673","wikidata":"https://www.wikidata.org/wiki/Q4034536","display_name":"Atlanta","level":3,"score":0.8359065055847168},{"id":"https://openalex.org/C2993838110","wikidata":"https://www.wikidata.org/wiki/Q494230","display_name":"Medical school","level":2,"score":0.484797865152359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4166058897972107},{"id":"https://openalex.org/C2780708616","wikidata":"https://www.wikidata.org/wiki/Q193866","display_name":"Annals","level":2,"score":0.41055986285209656},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.38382354378700256},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.34755223989486694},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.17900070548057556},{"id":"https://openalex.org/C74916050","wikidata":"https://www.wikidata.org/wiki/Q841090","display_name":"Classics","level":1,"score":0.13835495710372925},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.13102126121520996},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C158739034","wikidata":"https://www.wikidata.org/wiki/Q1907114","display_name":"Metropolitan area","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000525","descriptor_name":"Alprazolam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1992.tb25963.x","doi":"https://doi.org/10.1111/j.1749-6632.1992.tb25963.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1992.tb25963.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:1632579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1632579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1427231767","display_name":"Psychobiology of Corticotropin-releasing Factor","funder_award_id":"R01MH042088","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6578515407","display_name":null,"funder_award_id":"NIAAA 00098","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G837034738","display_name":null,"funder_award_id":"NIAAA 06059","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000913934","display_name":"Effects of alcohol on sleep/activity rhythms: Focus on Hypocretin/Orexin","funder_award_id":"R01AA006059","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W5442471","https://openalex.org/W789493075","https://openalex.org/W1746517967","https://openalex.org/W1883490266","https://openalex.org/W1892264246","https://openalex.org/W1902016348","https://openalex.org/W1944491216","https://openalex.org/W1961661934","https://openalex.org/W1965108410","https://openalex.org/W1965337556","https://openalex.org/W1972314609","https://openalex.org/W1973308205","https://openalex.org/W1973515363","https://openalex.org/W1974494540","https://openalex.org/W1976250357","https://openalex.org/W1979449248","https://openalex.org/W1980904592","https://openalex.org/W1994989677","https://openalex.org/W2003315903","https://openalex.org/W2003603935","https://openalex.org/W2003916405","https://openalex.org/W2008083522","https://openalex.org/W2008690448","https://openalex.org/W2009637266","https://openalex.org/W2017471052","https://openalex.org/W2018821655","https://openalex.org/W2020329681","https://openalex.org/W2023878197","https://openalex.org/W2027150121","https://openalex.org/W2029471287","https://openalex.org/W2030452259","https://openalex.org/W2034584065","https://openalex.org/W2041736210","https://openalex.org/W2041788158","https://openalex.org/W2041975134","https://openalex.org/W2044985824","https://openalex.org/W2048511631","https://openalex.org/W2049896516","https://openalex.org/W2050852492","https://openalex.org/W2050917344","https://openalex.org/W2053696472","https://openalex.org/W2055872879","https://openalex.org/W2056733192","https://openalex.org/W2056945518","https://openalex.org/W2066944493","https://openalex.org/W2070367492","https://openalex.org/W2076222908","https://openalex.org/W2081264545","https://openalex.org/W2083766817","https://openalex.org/W2085362834","https://openalex.org/W2086574534","https://openalex.org/W2086644290","https://openalex.org/W2087334617","https://openalex.org/W2088050052","https://openalex.org/W2088670213","https://openalex.org/W2095036452","https://openalex.org/W2116532759","https://openalex.org/W2123455622","https://openalex.org/W2125906082","https://openalex.org/W2133753087","https://openalex.org/W2135378706","https://openalex.org/W2153608765","https://openalex.org/W2163145678","https://openalex.org/W2246782786","https://openalex.org/W2267311180","https://openalex.org/W2327254632","https://openalex.org/W2335701682","https://openalex.org/W2399182591","https://openalex.org/W2418177865","https://openalex.org/W2419392852","https://openalex.org/W2425402185","https://openalex.org/W2441418130","https://openalex.org/W2475243356","https://openalex.org/W4230030873","https://openalex.org/W4318599785","https://openalex.org/W4324289996","https://openalex.org/W4406985615"],"related_works":["https://openalex.org/W175127641","https://openalex.org/W2508078538","https://openalex.org/W2028259766","https://openalex.org/W2010827811","https://openalex.org/W4382236801","https://openalex.org/W2538056577","https://openalex.org/W6946315954","https://openalex.org/W1975033598","https://openalex.org/W3099559198","https://openalex.org/W2103367878"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
