{"id":"https://openalex.org/W2072663152","doi":"https://doi.org/10.1016/0003-9861(89)90238-5","title":"Liver mitochondrial aldehyde dehydrogenase: In vitro expression, in vitro import, and effect of alcohols on import","display_name":"Liver mitochondrial aldehyde dehydrogenase: In vitro expression, in vitro import, and effect of alcohols on import","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W2072663152","doi":"https://doi.org/10.1016/0003-9861(89)90238-5","mag":"2072663152","pmid":"https://pubmed.ncbi.nlm.nih.gov/2751310"},"language":"en","primary_location":{"id":"doi:10.1016/0003-9861(89)90238-5","doi":"https://doi.org/10.1016/0003-9861(89)90238-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-9861(89)90238-5","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086523704","display_name":"Thomas T. Y. Wang","orcid":"https://orcid.org/0000-0003-2299-9452","observed_orcids":["https://orcid.org/0000-0003-2299-9452"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas T.Y. Wang","raw_affiliation_strings":["Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907","Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907. USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021974002","display_name":"Jaume Farr\u00e9s","orcid":"https://orcid.org/0000-0001-9069-3987","observed_orcids":["https://orcid.org/0000-0001-9069-3987"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaume Farr\u00e9s","raw_affiliation_strings":["Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907 USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012958448","display_name":"Henry Weiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Henry Weiner","raw_affiliation_strings":["Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907 USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012958448"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":1.4184,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.8232827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"272","issue":"2","first_page":"440","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mitochondrial-protein-import","display_name":"mitochondrial protein import","score":0.7549999952316284},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.7059999704360962},{"id":"https://openalex.org/keywords/liver-mitochondria","display_name":"liver mitochondria","score":0.7059999704360962},{"id":"https://openalex.org/keywords/ethanol-inhibition","display_name":"ethanol inhibition","score":0.6919999718666077},{"id":"https://openalex.org/keywords/alcohol-chemistry","display_name":"alcohol chemistry","score":0.796999990940094},{"id":"https://openalex.org/keywords/hydrocarbon-chain-length","display_name":"hydrocarbon chain length","score":0.656000018119812},{"id":"https://openalex.org/keywords/ornithine-transcarbamylase","display_name":"ornithine transcarbamylase","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mitochondrial-membrane","display_name":"mitochondrial membrane","score":0.847000002861023},{"id":"https://openalex.org/keywords/in-vitro-translation","display_name":"in vitro translation","score":0.4790000021457672},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.7433637976646423},{"id":"https://openalex.org/C3175096","wikidata":"https://www.wikidata.org/wiki/Q2640417","display_name":"ALDH2","level":4,"score":0.6981270909309387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6893888711929321},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6223689913749695},{"id":"https://openalex.org/C2779825165","wikidata":"https://www.wikidata.org/wiki/Q101497","display_name":"Aldehyde","level":3,"score":0.5657992362976074},{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.5215892195701599},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5211703777313232},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5165478587150574},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.4526410698890686},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36857348680496216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3446579575538635},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000440","descriptor_name":"Butanols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009954","descriptor_name":"Ornithine Carbamoyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0003-9861(89)90238-5","doi":"https://doi.org/10.1016/0003-9861(89)90238-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-9861(89)90238-5","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:2751310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2751310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1491298630","display_name":null,"funder_award_id":"AA 00028","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G2454134384","display_name":null,"funder_award_id":"AA08512","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G4369617351","display_name":null,"funder_award_id":"AA05276","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1449793716","https://openalex.org/W1515733752","https://openalex.org/W1597868762","https://openalex.org/W1605480781","https://openalex.org/W1970403529","https://openalex.org/W1976423642","https://openalex.org/W1989203010","https://openalex.org/W2020174073","https://openalex.org/W2021978074","https://openalex.org/W2034156633","https://openalex.org/W2037151955","https://openalex.org/W2039183968","https://openalex.org/W2042182746","https://openalex.org/W2069358454","https://openalex.org/W2075145643","https://openalex.org/W2080037227","https://openalex.org/W2081351575","https://openalex.org/W2084726236","https://openalex.org/W2085024565","https://openalex.org/W2085971755","https://openalex.org/W2128635872","https://openalex.org/W2152214802","https://openalex.org/W2282054059","https://openalex.org/W2313835802","https://openalex.org/W2473269561","https://openalex.org/W2496972857","https://openalex.org/W2910103400"],"related_works":["https://openalex.org/W2146651676","https://openalex.org/W3017624254","https://openalex.org/W2090819815","https://openalex.org/W2425227562","https://openalex.org/W2001679021","https://openalex.org/W2414934685","https://openalex.org/W1985518019","https://openalex.org/W2084800907","https://openalex.org/W1491808891","https://openalex.org/W2157679807"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}