{"id":"https://openalex.org/W2072648558","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p2-18-12","title":"Abstract P2-18-12: Surgical management of breast cancer: Breast conserving surgery or mastectomy in the 2010 SEER registries by hormone receptor and HER2 status","display_name":"Abstract P2-18-12: Surgical management of breast cancer: Breast conserving surgery or mastectomy in the 2010 SEER registries by hormone receptor and HER2 status","publication_year":2013,"publication_date":"2013-12-15","ids":{"openalex":"https://openalex.org/W2072648558","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p2-18-12","mag":"2072648558"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.sabcs13-p2-18-12","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p2-18-12","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-p2-18-12","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112257097","display_name":"MC Schroeder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MC Schroeder","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030038680","display_name":"SL Sugg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SL Sugg","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112172073","display_name":"JM Brooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JM Brooks","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013288976","display_name":"Alexandra Thomas","orcid":"https://orcid.org/0000-0001-9022-2229","observed_orcids":["https://orcid.org/0000-0001-9022-2229"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Thomas","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"24_Supplement","first_page":"P2","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-surgery","display_name":"breast cancer surgery","score":0.8629999756813049},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mastectomy-rates","display_name":"mastectomy rates","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.7749999761581421},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.9279999732971191},{"id":"https://openalex.org/keywords/breast-cancer-subtypes","display_name":"breast cancer subtypes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/locoregional-recurrence","display_name":"locoregional recurrence","score":0.8370000123977661},{"id":"https://openalex.org/keywords/stage-at-diagnosis","display_name":"stage at diagnosis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/seer-database","display_name":"SEER database","score":0.6890000104904175},{"id":"https://openalex.org/keywords/surgical-decision-making","display_name":"surgical decision-making","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8818300366401672},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.781812310218811},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.6880819201469421},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6464523673057556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5851710438728333},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5541342496871948},{"id":"https://openalex.org/C2781467025","wikidata":"https://www.wikidata.org/wiki/Q4959754","display_name":"Breast-conserving surgery","level":5,"score":0.5040901899337769},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49387818574905396},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.4688587784767151},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.41916215419769287},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3798772394657135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.sabcs13-p2-18-12","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p2-18-12","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-p2-18-12","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W282724840","https://openalex.org/W1539325367","https://openalex.org/W2292710242","https://openalex.org/W2589504456","https://openalex.org/W2938880491","https://openalex.org/W3131695922","https://openalex.org/W1977009893","https://openalex.org/W4308358013","https://openalex.org/W4388406490","https://openalex.org/W2073762437"],"abstract_inverted_index":{"Abstract":[0,483],"Background":[1],"Breast":[2],"conserving":[3,78],"therapy":[4,79],"and":[5,50,68,120,137,151,220,245,270,299,335,372,384,388,437,445],"mastectomy":[6,24,121,210,279,317,379,394,446,464],"have":[7,11,59,99,393],"been":[8],"shown":[9,60],"to":[10,160,312,348,392,413,415,424,471],"similar":[12],"overall":[13],"survival":[14],"outcomes":[15,101],"in":[16,134,167,404],"large":[17],"trials.":[18],"After":[19],"many":[20],"years":[21],"of":[22,33,45,148,198,276,358,377,428,462,474],"decline,":[23],"rates":[25,122,318],"are":[26,153],"on":[27,110],"the":[28,43,106,146,196,366,409],"rise":[29],"for":[30,66,131,212,235,281,291,295,301,308,321,324,327,330,333,337,343,419,449,467],"a":[31,374,425],"variety":[32],"reasons.":[34],"In":[35,175,352],"this":[36,353,405,468,475],"context,":[37],"there":[38],"is":[39,48,64,129,364],"increasing":[40,378],"discussion":[41],"that":[42,61,94],"risk":[44,432],"loco-regional":[46,62,430],"recurrence":[47,63,431],"complex":[49],"varies":[51],"by":[52,113,187,215,286,435,447],"breast":[53,71,77,96,114,139,163,402],"cancer":[54,72,97,115,164],"subtype.":[55,476],"Several,":[56],"pre-trastuzumab-era,":[57],"reports":[58],"higher":[65],"HER2+":[67,150,219,383,401],"triple":[69],"negative":[70],"(TNBC)":[73],"patients":[74,165,225,259],"who":[75],"undergo":[76,416],"(BCS)":[80],"compared":[81,311,347,470],"with":[82,84,102,143,226,260,382,400],"women":[83,142,242,277,344,359],"hormone":[85],"receptor":[86,216,228,262],"positive":[87],"(HR+)":[88],"disease.":[89],"Other":[90],"literature":[91],"has":[92],"suggested":[93],"some":[95],"subtypes":[98,229],"better":[100,426],"BCS.":[103],"To":[104],"provide":[105],"most":[107,411],"recent":[108,355],"data":[109,157,234],"surgical":[111,438],"choice":[112,128],"subtype,":[116],"we":[117],"report":[118],"BCS":[119,208,444],"from":[123,369],"2010":[124,236],"SEER":[125,156,233],"data.":[126],"Surgical":[127],"presented":[130],"ductal":[132],"carcinoma":[133],"situ":[135],"(DCIS)":[136],"invasive":[138,144,213,223,249,254,450],"cancer.":[140],"For":[141,222,253],"disease":[145,250,298],"subcategories":[147],"HR+,":[149],"TNBC":[152,385],"reported.":[154],"Methods":[155],"were":[158,173,178,182,203,230,265,268,272,319,386,408],"used":[159],"identify":[161],"incident":[162],"diagnosed":[166,183],"2010.":[168],"Only":[169],"pathologically":[170],"confirmed":[171],"cases":[172],"included.":[174],"addition,":[176],"individuals":[177],"excluded":[179],"if":[180,195],"they":[181],"at":[184,288],"autopsy":[185],"or":[186,194,209],"death":[188],"certificate,":[189],"did":[190],"not":[191,473],"receive":[192],"surgery":[193,199],"type":[197],"was":[200],"unknown.":[201],"Patients":[202],"categorized":[204],"as":[205],"having":[206],"received":[207],"and,":[211],"disease,":[214],"subtype":[217,410,436,448,469],"(HR+,":[218],"TNBC).":[221],"cancers,":[224],"unknown":[227,261],"excluded.":[231],"Results":[232],"included":[237],"65,598":[238],"women,":[239],"13,849":[240],"(21.1%)":[241],"had":[243,248],"DCIS":[244],"51,749":[246],"(78.9%)":[247],"(Table":[251],"1).":[252],"cancers":[255],"after":[256],"excluding":[257],"5,062":[258],"status,":[263],"12.1%":[264],"TNBC,":[266],"14.4%":[267],"HER2+,":[269],"83.5%":[271],"HR+.":[273],"Overall,":[274],"43.5%":[275,357],"underwent":[278,360],"(33.2%":[280],"DCIS).":[282],"Mastectomy":[283],"rate":[284,363],"increased":[285],"stage":[287],"diagnosis:":[289],"33.5%":[290],"Stage":[292,296,302,309],"I,":[293],"53.9%":[294],"II":[297],"77.8%":[300],"III":[303],"(OR":[304,339],"=":[305,340],"0.49,":[306],"p<0.001":[307,342],"1":[310],"other":[313],"stages).":[314],"By":[315],"age,":[316],"69.0%":[320],"<30,":[322],"53.4%":[323],"30-49,":[325],"43.3%":[326],"50-59,":[328],"39.0%":[329],"60-69,":[331],"39.4%":[332],"70-79":[334],"41.1%":[336],"80+":[338],"2.90,":[341],"under":[345],"30":[346],"older":[349],"women).":[350],"Conclusions":[351],"large,":[354],"series,":[356],"mastectomy.":[361,417],"This":[362],"among":[365],"highest":[367],"reported":[368],"population-based":[370],"registries":[371],"suggests":[373],"continued":[375],"trend":[376],"rates.":[380],"Women":[381,399],"younger":[387],"significantly":[389],"more":[390],"likely":[391,412],"than":[395],"their":[396],"HR+":[397],"counterparts.":[398],"cancer,":[403],"trastuzumab-era":[406],"cohort,":[407],"choose":[414],"Monitoring":[418],"relapse":[420],"events":[421],"could":[422],"contribute":[423],"understanding":[427],"how":[429],"might":[433],"vary":[434],"choice.":[439],"Table":[440],"1:":[441],"Percent":[442],"receiving":[443],"cancersReceptor":[451],"StatusNMean":[452],"AgeBCS":[453],"(%)Mastectomy":[454],"(%)Odds":[455],"Ratio*p":[456],"valueFull":[457],"cohort51,74961.354.145.9":[458],"HR+38,98161.855.744.30.68<0.001HER2+6,73858.143.056.01.61<0.001TNBC5,65858.849.150.91.26<0.001*":[459],"Odds":[460],"Ratio":[461],"undergoing":[463],"versus":[465],"lumpectomy":[466],"those":[472],"Citation":[477],"Information:":[478],"Cancer":[479],"Res":[480],"2013;73(24":[481],"Suppl):":[482],"nr":[484],"P2-18-12.":[485]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}