{"id":"https://openalex.org/W2072619022","doi":"https://doi.org/10.1158/1538-7445.fbcr13-a39","title":"Abstract A39: BACH1 and RKIP participate in a bistable network that affects progression to metastasis in breast Cancer","display_name":"Abstract A39: BACH1 and RKIP participate in a bistable network that affects progression to metastasis in breast Cancer","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2072619022","doi":"https://doi.org/10.1158/1538-7445.fbcr13-a39","mag":"2072619022"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.fbcr13-a39","doi":"https://doi.org/10.1158/1538-7445.fbcr13-a39","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.fbcr13-a39","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100447434","display_name":"Jiyoung Lee","orcid":"https://orcid.org/0000-0001-8503-4805","observed_orcids":["https://orcid.org/0000-0001-8503-4805"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyoung Lee","raw_affiliation_strings":["1The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009903231","display_name":"Jieun Yun","orcid":"https://orcid.org/0000-0002-4241-4274","observed_orcids":["https://orcid.org/0000-0002-4241-4274"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jieun Yun","raw_affiliation_strings":["1The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015648467","display_name":"Kam C. Yeung","orcid":"https://orcid.org/0000-0002-1415-484X","observed_orcids":["https://orcid.org/0000-0002-1415-484X"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kam Yeung","raw_affiliation_strings":["2The University of Toledo, Toledo, OH,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The University of Toledo, Toledo, OH,","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074487170","display_name":"Elena Bevilacqua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Bevilacqua","raw_affiliation_strings":["1The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050076723","display_name":"G\u00e1bor Bal\u00e1zsi","orcid":"https://orcid.org/0000-0002-6865-5818","observed_orcids":["https://orcid.org/0000-0002-6865-5818"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G\u00e1bor Bal\u00e1zsi","raw_affiliation_strings":["3The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035583989","display_name":"Marsha Rich Rosner","orcid":"https://orcid.org/0000-0001-6586-8335","observed_orcids":["https://orcid.org/0000-0001-6586-8335"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marsha Rich Rosner","raw_affiliation_strings":["1The University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"19_Supplement","first_page":"A39","last_page":"A39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bach1","display_name":"BACH1","score":1.0},{"id":"https://openalex.org/keywords/rkip","display_name":"RKIP","score":0.8859999775886536},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/metastasis-suppressor","display_name":"metastasis suppressor","score":0.7960000038146973},{"id":"https://openalex.org/keywords/double-negative-feedback-loop","display_name":"double-negative feedback loop","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.7710000276565552},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7582661509513855},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.659917950630188},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6571255326271057},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6420204639434814},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5251024961471558},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5000877380371094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38121551275253296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3730695843696594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.298587441444397},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16876459121704102},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10288304090499878}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.fbcr13-a39","doi":"https://doi.org/10.1158/1538-7445.fbcr13-a39","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.fbcr13-a39","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2124245667","https://openalex.org/W3004509924","https://openalex.org/W2087838522","https://openalex.org/W4383067023","https://openalex.org/W6958155744","https://openalex.org/W2132619290","https://openalex.org/W2028215082","https://openalex.org/W2106435751","https://openalex.org/W4313425348","https://openalex.org/W6958357690"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"sources":[2],"of":[3,97,105,112,185],"nongenetic":[4,127],"variability":[5],"in":[6,54,64,76,144,148,170,179,193],"metastatic":[7,146],"progression":[8,147,176],"are":[9],"largely":[10],"unknown.":[11],"To":[12],"address":[13],"this":[14],"question,":[15],"we":[16,59],"characterized":[17],"a":[18,65,113,141,171],"transcriptional":[19],"regulatory":[20],"network":[21,108,173],"for":[22],"the":[23,35,106,110,134,186],"metastasis":[24,178],"suppressor":[25],"Raf":[26],"Kinase":[27],"Inhibitory":[28],"Protein":[29],"(RKIP).":[30],"We":[31],"previously":[32],"showed":[33],"that":[34,61,121,133,174],"transcription":[36,75],"factor":[37],"BACH1":[38,62,80,90,107,118,139,166],"is":[39],"negatively":[40,49,82],"regulated":[41],"by":[42],"RKIP,":[43],"promotes":[44],"breast":[45,56,77,149,180],"cancer":[46,78],"metastasis,":[47],"and":[48,119,138,167],"correlates":[50],"with":[51],"RKIP":[52,74,93,102,120,137,168],"expression":[53],"primary":[55],"tumors.":[57],"Here":[58],"demonstrate":[60],"acts":[63],"double":[66],"negative":[67],"(overall":[68],"positive)":[69],"feedback":[70],"loop":[71],"to":[72,126,177],"inhibit":[73],"cells.":[79],"also":[81],"regulates":[83],"its":[84],"own":[85],"transcription.":[86,103],"HDAC":[87],"inhibitors":[88],"increased":[89],"but":[91],"not":[92],"transcription,":[94],"whereas":[95],"depletion":[96],"polycomb":[98],"repressor":[99],"EZH2":[100],"induced":[101],"Analysis":[104],"reveals":[109],"existence":[111],"bistable,":[114],"inverse":[115],"relationship":[116],"between":[117,136],"can":[122],"potentially":[123],"give":[124],"rise":[125],"variability.":[128],"Together,":[129],"our":[130],"results":[131],"suggest":[132],"balance":[135],"plays":[140],"key":[142],"role":[143],"determining":[145],"cancers.":[150],"Citation":[151],"Format:":[152],"Jiyoung":[153],"Lee,":[154],"Jieun":[155],"Yun,":[156],"Kam":[157],"Yeung,":[158],"Elena":[159],"Bevilacqua,":[160],"G\u00e1bor":[161],"Bal\u00e1zsi,":[162],"Marsha":[163],"Rich":[164],"Rosner.":[165],"participate":[169],"bistable":[172],"affects":[175],"Cancer.":[181],"[abstract].":[182],"In:":[183],"Proceedings":[184],"Third":[187],"AACR":[188],"International":[189],"Conference":[190],"on":[191],"Frontiers":[192],"Basic":[194],"Cancer":[195,206],"Research;":[196],"Sep":[197],"18-22,":[198],"2013;":[199],"National":[200],"Harbor,":[201],"MD.":[202],"Philadelphia":[203],"(PA):":[204],"AACR;":[205],"Res":[207],"2013;73(19":[208],"Suppl):Abstract":[209],"nr":[210],"A39.":[211]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
