{"id":"https://openalex.org/W2072616464","doi":"https://doi.org/10.1158/1538-7445.am10-3394","title":"Abstract 3394: CITED2: A potential facilitator of breast cancer metastasis","display_name":"Abstract 3394: CITED2: A potential facilitator of breast cancer metastasis","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2072616464","doi":"https://doi.org/10.1158/1538-7445.am10-3394","mag":"2072616464"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-3394","doi":"https://doi.org/10.1158/1538-7445.am10-3394","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-3394","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007508474","display_name":"Wen Min Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen Min Lau","raw_affiliation_strings":["1Johns Hopkins Univ. School of Medicine, Baltimore, MD","#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins Univ. School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michele Doucet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele Doucet","raw_affiliation_strings":["1Johns Hopkins Univ. School of Medicine, Baltimore, MD","#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins Univ. School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078376026","display_name":"Yu\u2010Ting Chou","orcid":"https://orcid.org/0000-0001-9274-8603","observed_orcids":["https://orcid.org/0000-0001-9274-8603"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Ting Chou","raw_affiliation_strings":["1Johns Hopkins Univ. School of Medicine, Baltimore, MD","#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins Univ. School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074097376","display_name":"KRISTY L. WEBER","orcid":"https://orcid.org/0000-0001-8021-011X","observed_orcids":["https://orcid.org/0000-0001-8021-011X","https://orcid.org/0009-0007-6941-8885"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristy L. Weber","raw_affiliation_strings":["1Johns Hopkins Univ. School of Medicine, Baltimore, MD","#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins Univ. School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053081399","display_name":"Scott L. Kominsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott L. Kominsky","raw_affiliation_strings":["1Johns Hopkins Univ. School of Medicine, Baltimore, MD","#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins Univ. School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"#N# 1Johns Hopkins University, School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"3394","last_page":"3394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.35569998621940613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cited2","display_name":"CITED2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.921999990940094},{"id":"https://openalex.org/keywords/osteolysis","display_name":"osteolysis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5860000252723694},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.492000013589859},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.7879999876022339},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.5979999899864197},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.30300000309944153},{"id":"https://openalex.org/keywords/mammary-organoids","display_name":"mammary organoids","score":0.6549999713897705},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6675378680229187},{"id":"https://openalex.org/C2776831358","wikidata":"https://www.wikidata.org/wiki/Q1150166","display_name":"Facilitator","level":2,"score":0.5678144693374634},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5257052779197693},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48708677291870117},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46845412254333496},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.457502156496048},{"id":"https://openalex.org/C2993589390","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Breast cancer metastasis","level":5,"score":0.4538685977458954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40590953826904297},{"id":"https://openalex.org/C2992691968","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Cancer metastasis","level":4,"score":0.16857114434242249},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.06377047300338745},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-3394","doi":"https://doi.org/10.1158/1538-7445.am10-3394","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-3394","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043522349","https://openalex.org/W2402272345","https://openalex.org/W2479697414","https://openalex.org/W2519255090","https://openalex.org/W4251351058","https://openalex.org/W808457919","https://openalex.org/W1995360688","https://openalex.org/W4386790494","https://openalex.org/W2002257560","https://openalex.org/W2902109420"],"abstract_inverted_index":{"Abstract":[0],"Metastasis":[1],"is":[2,21],"the":[3,22,25,29,33,50,65,81,191,211,248,304,331,364,372,409,423,430,445,450],"ultimate":[4],"cause":[5],"of":[6,24,35,43,58,68,83,117,139,193,221,250,271,287,307,327,333,363,371,380,393,412,444,449],"mortality":[7],"in":[8,70,86,104,147,175,199,228,274,297,330,407],"breast":[9,44,75,88,106,148,158,177,213,413],"cancer":[10,45,76,89,149,214,251,414],"patients.":[11],"Critical":[12],"to":[13,16,124,155,182,253,280,336,434],"our":[14],"ability":[15,249,385],"prevent":[17],"and":[18,32,162,179,255,368,376],"treat":[19],"metastasis":[20,72,273],"identification":[23],"key":[26],"factors":[27],"mediating":[28],"metastatic":[30,410],"process":[31],"understanding":[34],"their":[36],"biological":[37],"function.":[38],"Using":[39],"a":[40,55,337,344,402],"murine":[41],"model":[42],"metastasis,":[46],"we":[47,62,79,195,264],"recently":[48],"identified":[49],"transcriptional":[51,305],"co-activator":[52],"CITED2":[53,69,84,95,140,170,194,201,222,245,277,288,328,381,394,406],"as":[54,320,341],"potential":[56,66,403,411],"mediator":[57],"bone":[59,272],"metastasis.":[60],"Here,":[61],"further":[63,354],"explore":[64],"role":[67,404],"facilitating":[71],"using":[73,210],"human":[74,87,212],"cells.":[77,415],"First,":[78],"examined":[80],"expression":[82,202,220,326,362,370,382],"mRNA":[85,96,137,168],"patient":[90],"samples":[91],"by":[92,186,230,299,322,343,356,386],"qRT-PCR.":[93,323],"Interestingly,":[94],"levels":[97,138,172,289,392],"were":[98,141,173],"significantly":[99,142,238,290],"(p":[100,143,240,291],"<":[101,144,241,292],"0.05)":[102,145,293],"elevated":[103,146,174],"primary":[105,157,176],"tumors":[107,159,178],"from":[108,115,160],"patients":[109],"surviving":[110],"less":[111],"than":[112,129],"5":[113,130],"years":[114,131],"time":[116],"diagnosis":[118],"(non-survivors,":[119],"n":[120,133],"=":[121,134,152],"8)":[122],"relative":[123,154,181,279],"those":[125],"who":[126],"survived":[127],"greater":[128],"(survivors,":[132],"11).":[135],"Further,":[136,378],"metastases":[150,180],"(n":[151],"25)":[153],"both":[156],"survivors":[161],"normal":[163,183],"mammary":[164,184],"organoids.":[165],"Consistent":[166,260],"with":[167,261,303],"expression,":[169],"protein":[171,361],"epithelium":[185],"immunohistochemical":[187],"analysis.":[188],"To":[189],"investigate":[190],"function":[192],"generated":[196],"cell":[197,215,226,295,311],"lines":[198],"which":[200],"was":[203,237,353,419,432],"stably":[204],"increased":[205,219,369,391],"(CITED2)":[206],"or":[207],"decreased":[208,360],"(shCITED2)":[209],"line":[216],"MDA-MB-231.":[217],"While":[218],"did":[223],"not":[224,420],"affect":[225],"proliferation":[227,296],"vitro":[229,298],"MTS":[231,300],"assay,":[232,301,389],"survival":[233],"following":[234],"intracardiac":[235],"injection":[236],"reduced":[239,325],"0.01)":[242],"suggesting":[243],"that":[244],"may":[246],"enhance":[247],"cells":[252,278,335],"survive":[254],"grow":[256],"at":[257,269,422],"secondary":[258],"sites.":[259],"this":[262],"hypothesis,":[263],"also":[265],"observed":[266,321],"enhanced":[267,395],"osteolysis":[268],"sites":[270],"animals":[275],"harboring":[276],"vector":[281],"control.":[282],"In":[283],"contrast,":[284],"stable":[285],"reduction":[286,379],"inhibited":[294,383],"consistent":[302],"regulation":[306],"numerous":[308],"genes":[309],"controlling":[310],"cycle":[312],"events":[313],"(eg.":[314],"cyclin":[315],"E,":[316],"cdk1,":[317],"p21,":[318],"ATM)":[319],"Moreover,":[324],"resulted":[329],"reversion":[332],"MDA-MB-231":[334],"more":[338,345],"epithelial-like":[339],"phenotype":[340],"evidenced":[342],"cuboidal":[346],"morphology":[347],"under":[348],"light":[349],"microscopy.":[350],"This":[351,417],"observation":[352],"supported":[355],"Western":[357],"analysis":[358],"demonstrating":[359],"mesenchymal":[365],"marker":[366],"vimentin":[367],"epithelial":[373],"markers":[374],"E-cadherin":[375],"claudin-3.":[377],"invasive":[384],"Matrigel":[387],"invasion":[388],"while":[390],"invasion.":[396],"Taken":[397],"together,":[398],"these":[399],"data":[400],"support":[401],"for":[405,453],"regulating":[408],"Note:":[416],"abstract":[418],"presented":[421],"AACR":[424],"101st":[425,446],"Annual":[426,447],"Meeting":[427,448],"2010":[428,456],"because":[429],"presenter":[431],"unable":[433],"attend.":[435],"Citation":[436],"Format:":[437],"{Authors}.":[438],"{Abstract":[439],"title}":[440],"[abstract].":[441],"In:":[442],"Proceedings":[443],"American":[451],"Association":[452],"Cancer":[454,464],"Research;":[455],"Apr":[457],"17-21;":[458],"Washington,":[459],"DC.":[460],"Philadelphia":[461],"(PA):":[462],"AACR;":[463],"Res":[465],"2010;70(8":[466],"Suppl):Abstract":[467],"nr":[468],"3394.":[469]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
