{"id":"https://openalex.org/W2072591237","doi":"https://doi.org/10.1007/s003840100301","title":"Prolonged activation of mitogen-activated protein kinases during NSAID-induced apoptosis in HT-29 colon cancer cells","display_name":"Prolonged activation of mitogen-activated protein kinases during NSAID-induced apoptosis in HT-29 colon cancer cells","publication_year":2001,"publication_date":"2001-04-26","ids":{"openalex":"https://openalex.org/W2072591237","doi":"https://doi.org/10.1007/s003840100301","mag":"2072591237","pmid":"https://pubmed.ncbi.nlm.nih.gov/11459290"},"language":"en","primary_location":{"id":"doi:10.1007/s003840100301","doi":"https://doi.org/10.1007/s003840100301","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s003840100301","pdf_url":null,"source":{"id":"https://openalex.org/S164699263","display_name":"International Journal of Colorectal Disease","issn_l":"0179-1958","issn":["0179-1958","1432-1262"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Colorectal Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/141896","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100324553","display_name":"Tae Il Kim","orcid":"https://orcid.org/0000-0003-4807-890X","observed_orcids":["https://orcid.org/0000-0003-4807-890X"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae Kim","raw_affiliation_strings":["Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. kimwonho@yumc.yonsei.ac.kr","Yonsei university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. kimwonho@yumc.yonsei.ac.kr","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Yonsei university","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112538481","display_name":"Soo Chang Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo Jin","raw_affiliation_strings":["Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","Yonsei university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Yonsei university","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031044460","display_name":"Won Ho Kim","orcid":"https://orcid.org/0000-0002-5682-9972","observed_orcids":["https://orcid.org/0000-0002-5682-9972"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won Kim","raw_affiliation_strings":["Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, #N#Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, #N#Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eun Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Kang","raw_affiliation_strings":["Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","Yonsei university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Yonsei university","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109336063","display_name":"Kang Yell Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kang Choi","raw_affiliation_strings":["Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, #N#Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, #N#Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054023639","display_name":"Hyun Sil Kim","orcid":"https://orcid.org/0000-0003-3614-1764","observed_orcids":["https://orcid.org/0000-0003-3614-1764"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Kim","raw_affiliation_strings":["Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","Yonsei university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Yonsei university","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069484753","display_name":"Sung Kwan Shin","orcid":"https://orcid.org/0000-0001-5466-1400","observed_orcids":["https://orcid.org/0000-0001-5466-1400"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Shin","raw_affiliation_strings":["Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","Yonsei university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Yonsei university","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007109089","display_name":"Jin Kyung Kang","orcid":"https://orcid.org/0000-0002-4431-6897","observed_orcids":["https://orcid.org/0000-0002-4431-6897"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Kang","raw_affiliation_strings":["Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","Yonsei university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Yonsei university","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.9866,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.86012623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"16","issue":"3","first_page":"167","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9670000076293945},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.6570000052452087},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mapk-erk-kinase","display_name":"MAPK/ERK kinase","score":0.8050000071525574},{"id":"https://openalex.org/keywords/sb203580","display_name":"SB203580","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antineoplastic-mechanism","display_name":"antineoplastic mechanism","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.7216809391975403},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6424497961997986},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.6287798881530762},{"id":"https://openalex.org/C163035849","wikidata":"https://www.wikidata.org/wiki/Q15326910","display_name":"MAPK14","level":5,"score":0.5576004385948181},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5401586294174194},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.4992637634277344},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4864232540130615},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.47987785935401917},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.4724348485469818},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.46448856592178345},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.459053635597229},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.43595802783966064},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3996720612049103},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38090401887893677},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34013473987579346},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.33789169788360596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3243967294692993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19546866416931152}],"mesh":[{"descriptor_ui":"D000077430","descriptor_name":"Nabumetone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077430","descriptor_name":"Nabumetone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077430","descriptor_name":"Nabumetone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002074","descriptor_name":"Butanones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002074","descriptor_name":"Butanones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002074","descriptor_name":"Butanones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013467","descriptor_name":"Sulindac","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013467","descriptor_name":"Sulindac","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013467","descriptor_name":"Sulindac","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s003840100301","doi":"https://doi.org/10.1007/s003840100301","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s003840100301","pdf_url":null,"source":{"id":"https://openalex.org/S164699263","display_name":"International Journal of Colorectal Disease","issn_l":"0179-1958","issn":["0179-1958","1432-1262"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Colorectal Disease","raw_type":"journal-article"},{"id":"pmid:11459290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11459290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of colorectal disease","raw_type":"Journal Article"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/141896","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/141896","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/141896","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/141896","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310468","display_name":"Handok","ror":"https://ror.org/00exehz38"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W133636034","https://openalex.org/W140965324","https://openalex.org/W1503637437","https://openalex.org/W1528969230","https://openalex.org/W1539601638","https://openalex.org/W1547128430","https://openalex.org/W1579616493","https://openalex.org/W1596781203","https://openalex.org/W1598952686","https://openalex.org/W1648593433","https://openalex.org/W1876192519","https://openalex.org/W1973082494","https://openalex.org/W1976385326","https://openalex.org/W1992360356","https://openalex.org/W1997932090","https://openalex.org/W2003487528","https://openalex.org/W2004271144","https://openalex.org/W2007986629","https://openalex.org/W2014777348","https://openalex.org/W2016359876","https://openalex.org/W2022914311","https://openalex.org/W2026307857","https://openalex.org/W2032254243","https://openalex.org/W2043707891","https://openalex.org/W2051281154","https://openalex.org/W2075104267","https://openalex.org/W2086766543","https://openalex.org/W2087224686","https://openalex.org/W2089880838","https://openalex.org/W2148255564","https://openalex.org/W2156861225","https://openalex.org/W2263192284","https://openalex.org/W2323366608","https://openalex.org/W2327667256","https://openalex.org/W2336215030","https://openalex.org/W2409830125","https://openalex.org/W2418654556"],"related_works":["https://openalex.org/W2086766543","https://openalex.org/W2130665175","https://openalex.org/W2004271144","https://openalex.org/W2022917812","https://openalex.org/W1974235572","https://openalex.org/W2099995204","https://openalex.org/W7099167766","https://openalex.org/W2033387723","https://openalex.org/W1964986946","https://openalex.org/W2084667605"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}