{"id":"https://openalex.org/W2072587426","doi":"https://doi.org/10.1016/j.tcm.2006.10.001","title":"Oral Brain Natriuretic Peptide: A Novel Strategy for Chronic Protein Therapy for Cardiovascular Disease","display_name":"Oral Brain Natriuretic Peptide: A Novel Strategy for Chronic Protein Therapy for Cardiovascular Disease","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2072587426","doi":"https://doi.org/10.1016/j.tcm.2006.10.001","mag":"2072587426","pmid":"https://pubmed.ncbi.nlm.nih.gov/17210472"},"language":"en","primary_location":{"id":"doi:10.1016/j.tcm.2006.10.001","doi":"https://doi.org/10.1016/j.tcm.2006.10.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tcm.2006.10.001","pdf_url":null,"source":{"id":"https://openalex.org/S37062379","display_name":"Trends in Cardiovascular Medicine","issn_l":"1050-1738","issn":["1050-1738","1873-2615"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052263620","display_name":"Alessandro Cataliotti","orcid":"https://orcid.org/0000-0001-5476-8523","observed_orcids":["https://orcid.org/0000-0001-5476-8523"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alessandro Cataliotti","raw_affiliation_strings":["Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA. cataliotti.alessandro@mayo.edu","Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA. cataliotti.alessandro@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090322167","display_name":"Horng H. Chen","orcid":"https://orcid.org/0000-0002-2315-0330","observed_orcids":["https://orcid.org/0000-0002-2315-0330"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Horng H. Chen","raw_affiliation_strings":["Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109257464","display_name":"Kenneth D. James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth D. James","raw_affiliation_strings":["Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101494602","display_name":"John C. Jr Burnett","orcid":"https://orcid.org/0000-0002-3414-1659","observed_orcids":["https://orcid.org/0000-0002-3414-1659"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Burnett","raw_affiliation_strings":["Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiorenal Research Laboratory and Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052263620"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4740,"currency":"USD","value_usd":4740},"apc_paid":null,"fwci":2.2339,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.88875999,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"17","issue":"1","first_page":"10","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6499999761581421},{"id":"https://openalex.org/keywords/natriuretic-peptide-system","display_name":"natriuretic peptide system","score":0.8529999852180481},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.8889999985694885},{"id":"https://openalex.org/keywords/heart-as-endocrine-organ","display_name":"heart as endocrine organ","score":0.8199999928474426},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6850000023841858},{"id":"https://openalex.org/keywords/therapeutic-peptides","display_name":"peptide therapeutics","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8166393041610718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.777646005153656},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6125260591506958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5245264172554016},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5040282607078552},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.46007758378982544},{"id":"https://openalex.org/C2775846464","wikidata":"https://www.wikidata.org/wiki/Q66360952","display_name":"Brain natriuretic peptide","level":3,"score":0.45357242226600647},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.42366480827331543},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.41874125599861145},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40401044487953186},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3734227418899536},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37207552790641785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06335559487342834}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045283","descriptor_name":"Natriuretic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D045283","descriptor_name":"Natriuretic Agents","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D045283","descriptor_name":"Natriuretic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tcm.2006.10.001","doi":"https://doi.org/10.1016/j.tcm.2006.10.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tcm.2006.10.001","pdf_url":null,"source":{"id":"https://openalex.org/S37062379","display_name":"Trends in Cardiovascular Medicine","issn_l":"1050-1738","issn":["1050-1738","1873-2615"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmid:17210472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17210472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in cardiovascular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3907268241","display_name":"Biology and Novel Therapeutics of Cardiovascular Peptides","funder_award_id":"P01HL076611","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G569541972","display_name":"Cardiac Peptides in Cardiorenal Protection","funder_award_id":"R01HL036634","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1490299254","https://openalex.org/W1555210583","https://openalex.org/W1976200721","https://openalex.org/W1981438457","https://openalex.org/W2002352450","https://openalex.org/W2005607216","https://openalex.org/W2011780678","https://openalex.org/W2017557087","https://openalex.org/W2034619044","https://openalex.org/W2043239905","https://openalex.org/W2050215340","https://openalex.org/W2052097767","https://openalex.org/W2071575321","https://openalex.org/W2081801091","https://openalex.org/W2087638953","https://openalex.org/W2092609165","https://openalex.org/W2094945284","https://openalex.org/W2095930245","https://openalex.org/W2107592448","https://openalex.org/W2111720825","https://openalex.org/W2114358130","https://openalex.org/W2136718447","https://openalex.org/W2154705621","https://openalex.org/W2165168977","https://openalex.org/W2168145859","https://openalex.org/W2404498480","https://openalex.org/W2411985090"],"related_works":["https://openalex.org/W2151798249","https://openalex.org/W2015911108","https://openalex.org/W2618283546","https://openalex.org/W1976277600","https://openalex.org/W2379829072","https://openalex.org/W2328065994","https://openalex.org/W2162326285","https://openalex.org/W2060125194","https://openalex.org/W2072248059","https://openalex.org/W2357149805"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}