{"id":"https://openalex.org/W2072575485","doi":"https://doi.org/10.1093/eurheartj/13.suppl_d.129","title":"Pharmacological basis for antihypertensive therapy with a novel dopamine agonist","display_name":"Pharmacological basis for antihypertensive therapy with a novel dopamine agonist","publication_year":1992,"publication_date":"1992-09-02","ids":{"openalex":"https://openalex.org/W2072575485","doi":"https://doi.org/10.1093/eurheartj/13.suppl_d.129","mag":"2072575485","pmid":"https://pubmed.ncbi.nlm.nih.gov/1356783"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/13.suppl_d.129","doi":"https://doi.org/10.1093/eurheartj/13.suppl_d.129","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/13.suppl_d.129","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"G. Haeusler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"G. Haeusler","raw_affiliation_strings":["Department of Pharmaceutical Research and Development, E. Merck, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Research and Development, E. Merck, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111615153","display_name":"Ingeborg Lues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Lues","raw_affiliation_strings":["Department of Pharmaceutical Research and Development E. Merck, Frankfurter Strasse 250, D-6100 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Research and Development E. Merck, Frankfurter Strasse 250, D-6100 Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109981173","display_name":"Klaus-Otto Minck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K.-O. Minck","raw_affiliation_strings":["Department of Pharmaceutical Research and Development E. Merck, Frankfurter Strasse 250, D-6100 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Research and Development E. Merck, Frankfurter Strasse 250, D-6100 Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069364433","display_name":"P. Schelling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. Schelling","raw_affiliation_strings":["Department of Pharmaceutical Research and Development E. Merck, Frankfurter Strasse 250, D-6100 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Research and Development E. Merck, Frankfurter Strasse 250, D-6100 Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109835656","display_name":"Christoph A. Seyfried","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. A. Seyfried","raw_affiliation_strings":["Department of Pharmaceutical Research and Development E. Merck, Frankfurter Strasse 250, D-6100 Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Research and Development E. Merck, Frankfurter Strasse 250, D-6100 Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I164928964"],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":0.3497,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.58612496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"suppl D","first_page":"129","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-agonists","display_name":"dopamine agonists","score":0.7419999837875366},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9649999737739563},{"id":"https://openalex.org/keywords/noradrenaline-release","display_name":"noradrenaline release","score":0.8679999709129333},{"id":"https://openalex.org/keywords/presynaptic-receptors","display_name":"presynaptic receptors","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.8489999771118164},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/indole-derivatives","display_name":"indole derivatives","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7569863796234131},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6379949450492859},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6159170269966125},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.554600715637207},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.5278216004371643},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4908314645290375},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4878961741924286},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4769514799118042},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.46923357248306274},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45527902245521545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43229928612709045},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.431140661239624},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.37429988384246826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13225409388542175}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/eurheartj/13.suppl_d.129","doi":"https://doi.org/10.1093/eurheartj/13.suppl_d.129","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/13.suppl_d.129","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},{"id":"pmid:1356783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1356783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409556517","https://openalex.org/W1985005719","https://openalex.org/W2299416386","https://openalex.org/W1500704870","https://openalex.org/W1990591848","https://openalex.org/W2037703041","https://openalex.org/W1999882720","https://openalex.org/W2027083829","https://openalex.org/W9051580","https://openalex.org/W2463696623"],"abstract_inverted_index":{"In":[0],"the":[1,9,22,33,37,39,45,56,59,64,95,105,110,119,141,179],"past,":[2],"nearly":[3],"all":[4],"major":[5],"mechanisms":[6],"involved":[7],"in":[8,77,94,151],"regulation":[10],"of":[11,17,29,54,58,67,70,86,107,123,140,154,161,170,189],"blood":[12,149],"pressure":[13,150],"have":[14],"become":[15],"targets":[16],"antihypertensive":[18],"drugs.":[19],"They":[20],"include":[21],"brain":[23],"stem":[24],"with":[25,132,178],"its":[26],"neuronal":[27],"circuits":[28],"central":[30],"cardiovascular":[31,96],"regulation,":[32],"sympathetic":[34,60,165,190],"neuro-effector":[35],"system,":[36,62],"kidney,":[38],"renin":[40],"angiotensin":[41],"aldosterone":[42],"system":[43,97],"and":[44],"vascular":[46],"smooth":[47],"muscle":[48],"cell.":[49],"There":[50],"are":[51,101,122],"various":[52,152],"ways":[53],"influencing":[55],"function":[57],"nervous":[61],"but":[63],"clinical":[65],"potential":[66],"one":[68],"mechanism":[69],"action":[71,136],"has":[72],"not":[73,102],"yet":[74],"been":[75],"explored":[76],"detail.":[78],"Drugs":[79],"that":[80,146,181],"inhibit":[81],"noradrenaline":[82,162],"release":[83,163,182],"through":[84,159],"stimulation":[85],"inhibitory":[87],"receptors":[88,115,177],"located":[89],"at":[90],"adrenergic":[91],"nerve":[92,166,191],"terminals":[93],"(inhibitory":[98],"presynaptic":[99,112,175],"receptors)":[100],"available":[103],"for":[104,138],"treatment":[106],"hypertension.":[108],"Among":[109],"multiple":[111],"receptors,":[113],"dopamine":[114,176],"which":[116],"belong":[117],"to":[118,186],"dopamine2":[120],"subtype,":[121],"particular":[124],"interest.":[125],"Carmoxirole":[126],"is":[127,172,184],"a":[128,133],"novel":[129],"indole":[130],"derivative":[131],"potent":[134],"agonist":[135],"selective":[137],"dopamine2-receptors":[139],"periphery.":[142],"Experimental":[143],"evidence":[144],"shows":[145],"carmoxirole":[147,171],"lowers":[148],"models":[153],"hypertension":[155],"mainly":[156],"or":[157],"exclusively":[158],"inhibition":[160,183],"from":[164],"endings.":[167],"This":[168],"effect":[169],"mediated":[173],"by":[174],"characteristic":[180],"restricted":[185],"low":[187],"rates":[188],"discharge.":[192]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
