{"id":"https://openalex.org/W2072541702","doi":"https://doi.org/10.1021/ja210475a","title":"Measurement and Theory of Hydrogen Bonding Contribution to Isosteric DNA Base Pairs","display_name":"Measurement and Theory of Hydrogen Bonding Contribution to Isosteric DNA Base Pairs","publication_year":2012,"publication_date":"2012-02-02","ids":{"openalex":"https://openalex.org/W2072541702","doi":"https://doi.org/10.1021/ja210475a","mag":"2072541702","pmid":"https://pubmed.ncbi.nlm.nih.gov/22300089","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3293652"},"language":"en","primary_location":{"id":"doi:10.1021/ja210475a","doi":"https://doi.org/10.1021/ja210475a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja210475a","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3293652","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074095631","display_name":"Omid Khakshoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omid Khakshoor","raw_affiliation_strings":["Department of Chemistry, Stanford University, Stanford, California 94305, United\rStates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Stanford University, Stanford, California 94305, United\rStates","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007309417","display_name":"Steven E. Wheeler","orcid":"https://orcid.org/0000-0001-7824-6906","observed_orcids":["https://orcid.org/0000-0001-7824-6906"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven E. Wheeler","raw_affiliation_strings":["Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042178740","display_name":"Kendall N. Houk","orcid":"https://orcid.org/0000-0002-8387-5261","observed_orcids":["https://orcid.org/0000-0002-8387-5261"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. N. Houk","raw_affiliation_strings":["Department of Chemistry\rand\rBiochemistry, University of California,\rLos Angeles, California 90095, United States","Department of Chemistry#R#and#R#Biochemistry, University of California, Los Angeles, California 90095, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry\rand\rBiochemistry, University of California,\rLos Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Chemistry#R#and#R#Biochemistry, University of California, Los Angeles, California 90095, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078529502","display_name":"Eric T. Kool","orcid":"https://orcid.org/0000-0002-7310-2935","observed_orcids":["https://orcid.org/0000-0002-7310-2935","https://orcid.org/0000-0003-1125-2425"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric T. Kool","raw_affiliation_strings":["Department of Chemistry, Stanford University, Stanford, California 94305, United\rStates","Department, of Chemistry, Stanford University, Stanford, California 94305, United#R#States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Stanford University, Stanford, California 94305, United\rStates","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department, of Chemistry, Stanford University, Stanford, California 94305, United#R#States","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007309417","https://openalex.org/A5078529502"],"corresponding_institution_ids":["https://openalex.org/I91045830","https://openalex.org/I97018004"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.6971,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.90957097,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"134","issue":"6","first_page":"3154","last_page":"3163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-base-pairing","display_name":"DNA base pairing","score":0.5709999799728394},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8460000157356262},{"id":"https://openalex.org/keywords/duplex-stability","display_name":"duplex stability","score":0.6890000104904175},{"id":"https://openalex.org/keywords/noncovalent-interactions","display_name":"non-covalent interactions","score":0.6579999923706055},{"id":"https://openalex.org/keywords/nucleobase-analogs","display_name":"nucleobase analogs","score":0.6620000004768372},{"id":"https://openalex.org/keywords/dna-polymerase-active-site","display_name":"DNA polymerase active site","score":0.5770000219345093},{"id":"https://openalex.org/keywords/nucleic-acid-thermodynamics","display_name":"nucleic acid thermodynamics","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.897081196308136},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.789863109588623},{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.7667281627655029},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7361704111099243},{"id":"https://openalex.org/C14103023","wikidata":"https://www.wikidata.org/wiki/Q11681459","display_name":"Pairing","level":3,"score":0.7271610498428345},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.615730881690979},{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.6045787930488586},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.5194315910339355},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5009896755218506},{"id":"https://openalex.org/C61234307","wikidata":"https://www.wikidata.org/wiki/Q422960","display_name":"Nucleobase","level":3,"score":0.4413905739784241},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.43191853165626526},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.36937862634658813},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.35022756457328796},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.11729249358177185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09790253639221191},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C54101563","wikidata":"https://www.wikidata.org/wiki/Q124131","display_name":"Superconductivity","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020029","descriptor_name":"Base Pairing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/ja210475a","doi":"https://doi.org/10.1021/ja210475a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja210475a","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:22300089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22300089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2571977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3293652","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3293652","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3293652","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2571977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3293652","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G594650740","display_name":null,"funder_award_id":"GM 072705","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8253892943","display_name":"Probing Nucleotide Recognition in the Genetic Information Pathway","funder_award_id":"R01GM072705","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1584476217","https://openalex.org/W1931145733","https://openalex.org/W1985585525","https://openalex.org/W1986495208","https://openalex.org/W1986627932","https://openalex.org/W1988101843","https://openalex.org/W1989955252","https://openalex.org/W1991245376","https://openalex.org/W1996080607","https://openalex.org/W1996371195","https://openalex.org/W1996730574","https://openalex.org/W1998698630","https://openalex.org/W1999132213","https://openalex.org/W2000848890","https://openalex.org/W2005293741","https://openalex.org/W2009705294","https://openalex.org/W2011621113","https://openalex.org/W2020357919","https://openalex.org/W2020527875","https://openalex.org/W2022889126","https://openalex.org/W2024775042","https://openalex.org/W2029578044","https://openalex.org/W2030345664","https://openalex.org/W2033601423","https://openalex.org/W2037101039","https://openalex.org/W2038185700","https://openalex.org/W2039386852","https://openalex.org/W2039559098","https://openalex.org/W2046387060","https://openalex.org/W2048975464","https://openalex.org/W2058848030","https://openalex.org/W2062330462","https://openalex.org/W2067834816","https://openalex.org/W2071034307","https://openalex.org/W2072098707","https://openalex.org/W2073505350","https://openalex.org/W2073880037","https://openalex.org/W2079086324","https://openalex.org/W2079955502","https://openalex.org/W2081653306","https://openalex.org/W2084962104","https://openalex.org/W2085217231","https://openalex.org/W2088979606","https://openalex.org/W2095700720","https://openalex.org/W2105414505","https://openalex.org/W2105496576","https://openalex.org/W2106137858","https://openalex.org/W2124162379","https://openalex.org/W2127313259","https://openalex.org/W2129073323","https://openalex.org/W2141157874","https://openalex.org/W2141728056","https://openalex.org/W2147662196","https://openalex.org/W2149681483","https://openalex.org/W2150697053","https://openalex.org/W2158207944","https://openalex.org/W2160946836","https://openalex.org/W2163987996","https://openalex.org/W2951464747"],"related_works":["https://openalex.org/W2069345285","https://openalex.org/W2147662196","https://openalex.org/W2000848890","https://openalex.org/W2106137858","https://openalex.org/W2044933165","https://openalex.org/W2082908643","https://openalex.org/W2134098839","https://openalex.org/W1970355296","https://openalex.org/W2045652999","https://openalex.org/W6921864587"],"abstract_inverted_index":{"We":[0,138,367],"address":[1],"the":[2,6,103,114,140,160,197,208,262,278,289,311,317,343,364,369],"recent":[3,51,374],"debate":[4],"surrounding":[5],"ability":[7,29],"of":[8,14,30,55,105,119,142,199,244,264,283,292,298,300,304,353,373,378],"2,4-difluorotoluene":[9],"(F),":[10],"a":[11,19,80,123,200,348,359],"low-polarity":[12],"mimic":[13],"thymine":[15],"(T),":[16],"to":[17,37,45,90,94,101,225,294],"form":[18],"hydrogen-bonded":[20],"complex":[21],"with":[22,150,193,241,347,355],"adenine":[23,230,328],"in":[24,39,47,57,74,79,130,145,180,249,371],"DNA.":[25],"The":[26,320],"hydrogen":[27,66],"bonding":[28,67],"F":[31,70,86,222,293,354],"has":[32],"been":[33],"characterized":[34],"as":[35,191,239],"small":[36,46,349],"zero":[38],"various":[40],"experimental":[41,134],"studies,":[42],"and":[43,71,78,96,117,122,135,149,164,255,280,302,332,377],"moderate":[44],"computational":[48,136,274],"studies.":[49],"However,":[50],"X-ray":[52],"crystallographic":[53],"studies":[54,158,376],"difluorotoluene":[56],"DNA/RNA":[58],"have":[59],"indicated,":[60],"based":[61],"on":[62,108],"interatomic":[63],"distances,":[64],"possible":[65,152],"interactions":[68,203],"between":[69],"natural":[72],"bases":[73],"nucleic":[75],"acid":[76],"duplexes":[77],"DNA":[81,109,181,250,379],"polymerase":[82],"active":[83],"site.":[84],"Since":[85],"is":[87,99,182,217,223,251,296],"widely":[88],"used":[89],"measure":[91],"electrostatic":[92],"contributions":[93],"pairing":[95,115,153,179,216,290,334],"replication,":[97],"it":[98],"important":[100],"quantify":[102],"impact":[104],"this":[106,120,305],"isostere":[107],"stability.":[110],"Here,":[111],"we":[112],"studied":[113],"stability":[116],"selectivity":[118,243,326],"compound":[121],"closely":[124],"related":[125],"variant,":[126],"dichlorotoluene":[127,248],"deoxyriboside":[128],"(L),":[129],"DNA,":[131],"using":[132,159],"both":[133],"approaches.":[137],"measured":[139],"thermodynamics":[141],"duplex":[143],"formation":[144],"three":[146],"sequence":[147],"contexts":[148],"all":[151],"partners":[154],"by":[155,168,184,235,273,358],"thermal":[156],"melting":[157],"van't":[161],"Hoff":[162],"approach,":[163],"for":[165,220,229,327,340,363],"selected":[166],"cases":[167],"isothermal":[169],"titration":[170],"calorimetry":[171],"(ITC).":[172],"Experimental":[173,269],"results":[174,344],"showed":[175],"that":[176,288,299],"internal":[177],"F-A":[178,210],"destabilizing":[183,254],"3.8":[185],"kcal/mol":[186],"(van't":[187],"Hoff,":[188],"37":[189],"\u00b0C)":[190],"compared":[192,240],"T-A":[194,215],"pairing.":[195],"At":[196],"end":[198],"duplex,":[201],"base-base":[202],"are":[204,336,345],"considerably":[205],"smaller;":[206],"however,":[207],"net":[209],"interaction":[211,306,352],"remains":[212],"repulsive":[213],"while":[214],"attractive.":[218],"As":[219],"selectivity,":[221],"found":[224],"be":[226],"slightly":[227,252,256,337],"selective":[228,258],"over":[231,329],"C,":[232],"G,":[233],"T":[234],"0.5":[236],"kcal":[237],"mol,":[238],"thymine's":[242],"2.4":[245],"kcal/mol.":[246],"Interestingly,":[247],"less":[253],"more":[257],"than":[259,339],"F,":[260],"despite":[261],"lack":[263],"strongly":[265],"electronegative":[266],"fluorine":[267],"atoms.":[268],"data":[270],"were":[271],"complemented":[272],"results,":[275],"evaluated":[276],"at":[277],"M06-2X/6-31+G(d)":[279],"MP2/cc-pVTZ":[281],"levels":[282],"theory.":[284],"These":[285],"computations":[286],"suggest":[287],"energy":[291],"A":[295,356],"~28%":[297],"T-A,":[301],"most":[303],"does":[307],"not":[308],"arise":[309],"from":[310,316],"F\u00b7\u00b7\u00b7HN":[312],"interaction,":[313],"but":[314],"rather":[315],"CH\u00b7\u00b7\u00b7N":[318],"interaction.":[319],"nucleobase":[321],"analogue":[322],"shows":[323],"no":[324],"inherent":[325],"other":[330],"bases,":[331],"L-A":[333],"energies":[335],"weaker":[338],"F-A.":[341],"Overall,":[342],"consistent":[346],"favorable":[350],"noncovalent":[351],"offset":[357],"large":[360],"desolvation":[361],"cost":[362],"polar":[365],"partner.":[366],"discuss":[368],"findings":[370],"light":[372],"structural":[375],"replication":[380],"experiments":[381],"involving":[382],"these":[383],"analogues.":[384]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}