{"id":"https://openalex.org/W2072473501","doi":"https://doi.org/10.1002/(sici)1097-0223(199812)18:13<1381::aid-pd495>3.0.co;2-n","title":"Application of single-needle blastomere biopsy in human preimplantation genetic diagnosis","display_name":"Application of single-needle blastomere biopsy in human preimplantation genetic diagnosis","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2072473501","doi":"https://doi.org/10.1002/(sici)1097-0223(199812)18:13<1381::aid-pd495>3.0.co;2-n","mag":"2072473501","pmid":"https://pubmed.ncbi.nlm.nih.gov/9949438"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0223(199812)18:13<1381::aid-pd495>3.0.co;2-n","doi":"https://doi.org/10.1002/(sici)1097-0223(199812)18:13<1381::aid-pd495>3.0.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0223(199812)18:13<1381::aid-pd495>3.0.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S171405753","display_name":"Prenatal Diagnosis","issn_l":"0197-3851","issn":["0197-3851","1097-0223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prenatal Diagnosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088138259","display_name":"Jos\u00e9 Inzunza","orcid":"https://orcid.org/0000-0003-0876-6767","observed_orcids":["https://orcid.org/0000-0003-0876-6767"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J. Inzunza","raw_affiliation_strings":["Unit for Embryo and Genome Research, Huddinge University Hospital F61, Sweden","The Unit for Embryo and Genome Research, Clinical Research Centre, Huddinge University Hospital F61, Karolinska Institutet, S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit for Embryo and Genome Research, Huddinge University Hospital F61, Sweden","institution_ids":[]},{"raw_affiliation_string":"The Unit for Embryo and Genome Research, Clinical Research Centre, Huddinge University Hospital F61, Karolinska Institutet, S-141 86 Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005997456","display_name":"Erik Iwarsson","orcid":"https://orcid.org/0000-0002-3827-0263","observed_orcids":["https://orcid.org/0000-0002-3827-0263"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E. Iwarsson","raw_affiliation_strings":["Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079416125","display_name":"Margareta Fridstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Fridstr\u00f6m","raw_affiliation_strings":["Department of Clinical Sciences, Obstetrics and Gynaecology Unit, Huddinge University Hospital, S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Obstetrics and Gynaecology Unit, Huddinge University Hospital, S-141 86 Huddinge, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111531381","display_name":"Bj\u00f6rn Rosenlund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Rosenlund","raw_affiliation_strings":["Department of Clinical Sciences, Obstetrics and Gynaecology Unit, Huddinge University Hospital, S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Obstetrics and Gynaecology Unit, Huddinge University Hospital, S-141 86 Huddinge, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051120406","display_name":"Peter Sj\u00f6blom","orcid":"https://orcid.org/0000-0001-6164-4908","observed_orcids":["https://orcid.org/0000-0001-6164-4908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Sj\u00f6blom","raw_affiliation_strings":["Department of Clinical Sciences, Obstetrics and Gynaecology Unit, Huddinge University Hospital, S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Obstetrics and Gynaecology Unit, Huddinge University Hospital, S-141 86 Huddinge, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029294298","display_name":"Torbj\u00f6rn Hillensj\u00f8","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Hillensj\u00f6","raw_affiliation_strings":["Department of Clinical Sciences, Obstetrics and Gynaecology Unit, Huddinge University Hospital, S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Obstetrics and Gynaecology Unit, Huddinge University Hospital, S-141 86 Huddinge, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013751990","display_name":"Elisabeth Blennow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E. Blennow","raw_affiliation_strings":["Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038488100","display_name":"Bernt E. Jones","orcid":"https://orcid.org/0000-0002-0465-1885","observed_orcids":["https://orcid.org/0000-0002-0465-1885"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B. Jones","raw_affiliation_strings":["Department of Clinical Chemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden","Dept of Clinical Chemistry, Swedish Univ. of Agricultural Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]},{"raw_affiliation_string":"Dept of Clinical Chemistry, Swedish Univ. of Agricultural Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022577576","display_name":"Magnus Nordenskj\u00f6ld","orcid":"https://orcid.org/0000-0002-4974-425X","observed_orcids":["https://orcid.org/0000-0002-4974-425X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M. Nordenskj\u00f6ld","raw_affiliation_strings":["Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027714227","display_name":"I. \u00c4hrlund-Richter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"I. \u00c4hrlund-Richter","raw_affiliation_strings":["The Unit for Embryo and Genome Research, Clinical Research Centre, Huddinge University Hospital F61, Karolinska Institutet, S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Unit for Embryo and Genome Research, Clinical Research Centre, Huddinge University Hospital F61, Karolinska Institutet, S-141 86 Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027714227"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":1.9703,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.85665597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"13","first_page":"1381","last_page":"1388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preimplantation-genetic-diagnosis","display_name":"preimplantation genetic diagnosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/human-preimplantation-embryos","display_name":"human preimplantation embryos","score":0.9049999713897705},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C68760520","wikidata":"https://www.wikidata.org/wiki/Q882097","display_name":"Blastomere","level":4,"score":0.902847409248352},{"id":"https://openalex.org/C2778805741","wikidata":"https://www.wikidata.org/wiki/Q1501356","display_name":"Preimplantation genetic diagnosis","level":3,"score":0.8881206512451172},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6750280261039734},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5851092338562012},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5710192322731018},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.5337883830070496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5224536657333374},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4508768916130066},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4130639433860779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3652833104133606},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.3616963028907776},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29599305987358093},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2556145191192627},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1956826150417328}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001757","descriptor_name":"Blastomeres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004624","descriptor_name":"Embryo Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-0223(199812)18:13<1381::aid-pd495>3.0.co;2-n","doi":"https://doi.org/10.1002/(sici)1097-0223(199812)18:13<1381::aid-pd495>3.0.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0223(199812)18:13<1381::aid-pd495>3.0.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S171405753","display_name":"Prenatal Diagnosis","issn_l":"0197-3851","issn":["0197-3851","1097-0223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prenatal Diagnosis","raw_type":"journal-article"},{"id":"pmid:9949438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9949438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prenatal diagnosis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W165156436","https://openalex.org/W1015300732","https://openalex.org/W1821398537","https://openalex.org/W1977255499","https://openalex.org/W1984352944","https://openalex.org/W2020733083","https://openalex.org/W2057929408","https://openalex.org/W2073362237","https://openalex.org/W2100463463","https://openalex.org/W2116073351","https://openalex.org/W2122406769","https://openalex.org/W2153155759","https://openalex.org/W2157031233","https://openalex.org/W2258066394","https://openalex.org/W2419188616","https://openalex.org/W2738128030"],"related_works":["https://openalex.org/W2049153020","https://openalex.org/W1020251401","https://openalex.org/W4245150783","https://openalex.org/W2370886481","https://openalex.org/W2029340959","https://openalex.org/W2045377680","https://openalex.org/W1969968188","https://openalex.org/W4254546706","https://openalex.org/W2394039482","https://openalex.org/W4221109062"],"abstract_inverted_index":{"We":[0],"have":[1],"tested":[2],"and":[3,32,44,68,75,77,87,93,106],"subsequently":[4],"successfully":[5],"applied":[6],"a":[7,29,38,89,120,140],"single-needle":[8,141,153],"approach":[9,142,154],"to":[10,34,61,79,84,122,127],"obtain":[11],"blastomere":[12],"biopsies":[13,160],"from":[14],"human":[15,100,144],"preimplantation":[16,19,101],"embryos":[17,58],"for":[18,159],"genetic":[20],"diagnosis":[21],"(PGD).":[22],"The":[23],"method":[24],"was":[25,111],"first":[26,133],"evaluated":[27],"in":[28,42,45,143,161],"mouse":[30,50,57],"system":[31],"shown":[33,78],"be":[35,80],"compatible":[36],"with":[37,82,113],"high":[39],"degree":[40],"of":[41,48,91,108,116,135,139],"vitro":[43],"vivo":[46],"development":[47,67],"biopsied":[49,56],"embryos.":[51],"Furthermore,":[52],"we":[53,149],"showed":[54],"that":[55,151],"after":[59],"transfer":[60],"recipient":[62],"mice":[63],"underwent":[64],"implantation,":[65],"normal":[66,81],"delivery.":[69],"Litters":[70],"were":[71],"followed":[72,103],"through":[73],"puberty":[74],"adulthood":[76],"regard":[83],"sexual":[85],"function":[86],"also":[88],"panel":[90],"biochemical":[92],"morphological":[94],"parameters":[95],"including":[96],"organ":[97],"histology.":[98],"Successful":[99],"diagnosis,":[102],"by":[104],"pregnancies":[105],"birth":[107],"healthy":[109],"babies,":[110],"established":[112],"two":[114],"out":[115],"three":[117],"couples":[118],"carrying":[119],"risk":[121],"transmit":[123],"chromosomal":[124],"abnormalities":[125],"leading":[126],"severe":[128],"disease.":[129],"This":[130],"is":[131,155],"the":[132,136,152],"report":[134],"successful":[137],"use":[138],"PGD.":[145,162],"Considering":[146],"its":[147],"simplicity,":[148],"conclude":[150],"an":[156],"attractive":[157],"alternative":[158]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
