{"id":"https://openalex.org/W2072446532","doi":"https://doi.org/10.1371/journal.pone.0027384","title":"IRF8 Governs Expression of Genes Involved in Innate and Adaptive Immunity in Human and Mouse Germinal Center B Cells","display_name":"IRF8 Governs Expression of Genes Involved in Innate and Adaptive Immunity in Human and Mouse Germinal Center B Cells","publication_year":2011,"publication_date":"2011-11-11","ids":{"openalex":"https://openalex.org/W2072446532","doi":"https://doi.org/10.1371/journal.pone.0027384","mag":"2072446532","pmid":"https://pubmed.ncbi.nlm.nih.gov/22096565","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3214047"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0027384","doi":"https://doi.org/10.1371/journal.pone.0027384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0027384","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0027384&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0027384&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001062720","display_name":"Dong\u2010Mi Shin","orcid":"https://orcid.org/0000-0002-4240-9432","observed_orcids":["https://orcid.org/0000-0002-4240-9432"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong-Mi Shin","raw_affiliation_strings":["Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100683428","display_name":"Chang\u2010Hoon Lee","orcid":"https://orcid.org/0000-0002-4031-3795","observed_orcids":["https://orcid.org/0000-0002-4031-3795"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang-Hoon Lee","raw_affiliation_strings":["Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026308918","display_name":"Herbert C. Morse","orcid":"https://orcid.org/0000-0002-9331-3705","observed_orcids":["https://orcid.org/0000-0002-9331-3705"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Herbert C. Morse","raw_affiliation_strings":["Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026308918"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.9733,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.85583664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"11","first_page":"e27384","last_page":"e27384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.1525000035762787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irf8","display_name":"IRF8","score":1.0},{"id":"https://openalex.org/keywords/germinal-center-b-cells","display_name":"germinal center B cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.796999990940094},{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.7059999704360962},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":1.0},{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/follicular-dendritic-cells","display_name":"follicular dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/promoter-binding-sites","display_name":"promoter binding sites","score":0.6610000133514404},{"id":"https://openalex.org/keywords/transcription-factor-binding-motifs","display_name":"transcription factor binding motifs","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.8889320492744446},{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.8448314666748047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7250271439552307},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5761058330535889},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5131173729896545},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.466668039560318},{"id":"https://openalex.org/C3753494","wikidata":"https://www.wikidata.org/wiki/Q2631550","display_name":"Follicular dendritic cells","level":5,"score":0.46054476499557495},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.44062110781669617},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4322405457496643},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42255815863609314},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.41687408089637756},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3275120258331299},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.23829737305641174},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1918283998966217},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18233156204223633},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.12434658408164978},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.11983418464660645}],"mesh":[{"descriptor_ui":"D000099185","descriptor_name":"Interferon Regulatory Factor-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099232","descriptor_name":"Proto-Oncogene Protein Spi-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0027384","doi":"https://doi.org/10.1371/journal.pone.0027384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0027384","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0027384&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3214047","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3214047","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22096565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22096565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.288.3207","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.288.3207","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3c/17/PLoS_One_2011_Nov_11_6(11)_e27384.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e5d31ae0c02642a983c845d9ba6de025","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e5d31ae0c02642a983c845d9ba6de025","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 11, p e27384 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/131467","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/IRF8_Governs_Expression_of_Genes_Involved_in_Innate_and_Adaptive_Immunity_in_Human_and_Mouse_Germinal_Center_B_Cells/131467","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0027384","doi":"https://doi.org/10.1371/journal.pone.0027384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0027384","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0027384&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072446532.pdf","grobid_xml":"https://content.openalex.org/works/W2072446532.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1541863220","https://openalex.org/W1592326302","https://openalex.org/W1786654010","https://openalex.org/W1821858011","https://openalex.org/W1912262500","https://openalex.org/W1965694516","https://openalex.org/W1971995316","https://openalex.org/W1979353384","https://openalex.org/W1986097339","https://openalex.org/W1988871238","https://openalex.org/W2001988677","https://openalex.org/W2004871248","https://openalex.org/W2005042248","https://openalex.org/W2005606581","https://openalex.org/W2008228521","https://openalex.org/W2010090099","https://openalex.org/W2016240370","https://openalex.org/W2022261101","https://openalex.org/W2023566832","https://openalex.org/W2029275361","https://openalex.org/W2035915920","https://openalex.org/W2053595706","https://openalex.org/W2065085347","https://openalex.org/W2065601509","https://openalex.org/W2070216538","https://openalex.org/W2074025680","https://openalex.org/W2076477779","https://openalex.org/W2080028493","https://openalex.org/W2080457149","https://openalex.org/W2080475151","https://openalex.org/W2088901705","https://openalex.org/W2089644287","https://openalex.org/W2095005830","https://openalex.org/W2097948293","https://openalex.org/W2100706488","https://openalex.org/W2109004232","https://openalex.org/W2116187144","https://openalex.org/W2121496836","https://openalex.org/W2123480703","https://openalex.org/W2128557245","https://openalex.org/W2128936341","https://openalex.org/W2132309323","https://openalex.org/W2132456274","https://openalex.org/W2136610354","https://openalex.org/W2136752250","https://openalex.org/W2139683904","https://openalex.org/W2145010689","https://openalex.org/W2146961300","https://openalex.org/W2147446676","https://openalex.org/W2147640266","https://openalex.org/W2147737828","https://openalex.org/W2324792516","https://openalex.org/W2330690422"],"related_works":["https://openalex.org/W7095519943","https://openalex.org/W2552546853","https://openalex.org/W2529967691","https://openalex.org/W2109004232","https://openalex.org/W2065698207","https://openalex.org/W4313381276","https://openalex.org/W2990624711","https://openalex.org/W2147737828","https://openalex.org/W2128936341","https://openalex.org/W2937775576"],"abstract_inverted_index":{"IRF8":[0,77,96,161],"(Interferon":[1],"Regulatory":[2],"Factor":[3],"8)":[4],"is":[5,23,55],"a":[6,98],"transcription":[7],"factor":[8],"expressed":[9,56],"throughout":[10],"B":[11,30,44,64,83,173,184],"cell":[12,31],"differentiation":[13],"except":[14],"for":[15,140],"mature":[16,43,172],"plasma":[17],"cells.":[18,65,193],"Previous":[19],"studies":[20],"showed":[21,159],"it":[22],"part":[24],"of":[25,42,101,109,118,168,171,178],"the":[26,36,40,47,69,119,169,179],"transcriptional":[27,70,91],"network":[28],"governing":[29],"specification":[32],"and":[33,50,54,72,80,90,125,145,190],"commitment":[34],"in":[35,60,78,143],"bone":[37],"marrow,":[38],"regulates":[39],"distribution":[41],"cells":[45,84,174],"into":[46],"splenic":[48],"follicular":[49,187,191],"marginal":[51],"zone":[52],"compartments,":[53],"at":[57],"highest":[58],"levels":[59],"germinal":[61],"center":[62],"(GC)":[63],"Here,":[66],"we":[67],"investigated":[68],"programs":[71],"signaling":[73],"pathways":[74],"affected":[75],"by":[76,87,103,114],"human":[79],"mouse":[81],"GC":[82,183],"as":[85,153],"defined":[86,152],"ChIP-chip":[88],"analyses":[89],"profiling.":[92],"We":[93,157],"show":[94],"that":[95,160],"binds":[97],"large":[99],"number":[100],"genes":[102,139,163],"targeting":[104],"two":[105],"distinct":[106],"motifs,":[107],"half":[108],"which":[110],"are":[111],"also":[112,158],"targeted":[113,138],"PU.1.":[115],"Over":[116],"70%":[117],"binding":[120],"sites":[121],"localized":[122],"to":[123,165],"proximal":[124],"distal":[126],"promoter":[127],"regions":[128],"with":[129,148],"\u223c25%":[130],"being":[131],"intragenic.":[132],"There":[133],"was":[134],"significant":[135],"enrichment":[136],"among":[137,182],"those":[141],"involved":[142],"innate":[144],"adaptive":[146],"immunity":[147],"over":[149],"30%":[150],"previously":[151],"interferon":[154],"stimulated":[155],"genes.":[156],"target":[162],"contributes":[164],"multiple":[166],"aspects":[167],"biology":[170],"including":[175],"critical":[176],"components":[177],"molecular":[180],"crosstalk":[181],"cells,":[185,189],"T":[186],"helper":[188],"dendritic":[192]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}