{"id":"https://openalex.org/W2072446111","doi":"https://doi.org/10.1111/j.1749-6632.1985.tb50416.x","title":"Intermediate Filament Proteins as Distinguishing Markers of Cell Type and Differentiated State in Cultured Human Urinary Tract Epithelia","display_name":"Intermediate Filament Proteins as Distinguishing Markers of Cell Type and Differentiated State in Cultured Human Urinary Tract Epithelia","publication_year":1985,"publication_date":"1985-10-01","ids":{"openalex":"https://openalex.org/W2072446111","doi":"https://doi.org/10.1111/j.1749-6632.1985.tb50416.x","mag":"2072446111","pmid":"https://pubmed.ncbi.nlm.nih.gov/3866508"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1985.tb50416.x","doi":"https://doi.org/10.1111/j.1749-6632.1985.tb50416.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1985.tb50416.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1749-6632.1985.tb50416.x","source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1749-6632.1985.tb50416.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108202793","display_name":"James G. Rheinwald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JAMES G. RHEINWALD","raw_affiliation_strings":["Department of Physiology and Biophysics, Harvard Medical School, Boston, Massachusetts 02115","Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071586611","display_name":"Therese M. O\u2019Connell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"THERESE M. O'CONNELL","raw_affiliation_strings":["Department of Physiology and Biophysics, Harvard Medical School, Boston, Massachusetts 02115","Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":1.0397,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.75836106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"455","issue":"1","first_page":"259","last_page":"267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intermediate-filament-proteins","display_name":"intermediate filament proteins","score":0.9620000123977661},{"id":"https://openalex.org/keywords/keratin","display_name":"keratin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mesothelial-cells","display_name":"mesothelial cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/epithelial-differentiation","display_name":"epithelial differentiation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cell-type-markers","display_name":"cell type markers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/epithelial-cell-culture","display_name":"epithelial cell culture","score":0.6470000147819519},{"id":"https://openalex.org/keywords/squamous-epithelium","display_name":"squamous epithelium","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cell-growth-regulation","display_name":"cell growth regulation","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C2993838110","wikidata":"https://www.wikidata.org/wiki/Q494230","display_name":"Medical school","level":2,"score":0.580752432346344},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.4547351002693176},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.36086708307266235},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3603936433792114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2844824492931366},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11969402432441711},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.08244231343269348}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014551","descriptor_name":"Urinary Tract","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014551","descriptor_name":"Urinary Tract","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D014551","descriptor_name":"Urinary Tract","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1985.tb50416.x","doi":"https://doi.org/10.1111/j.1749-6632.1985.tb50416.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1985.tb50416.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1749-6632.1985.tb50416.x","source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:3866508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3866508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1749-6632.1985.tb50416.x","doi":"https://doi.org/10.1111/j.1749-6632.1985.tb50416.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1985.tb50416.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1749-6632.1985.tb50416.x","source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072446111.pdf","grobid_xml":"https://content.openalex.org/works/W2072446111.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W188486901","https://openalex.org/W1579523891","https://openalex.org/W1583233593","https://openalex.org/W1753193583","https://openalex.org/W1773698728","https://openalex.org/W1972092014","https://openalex.org/W1977068625","https://openalex.org/W1983851236","https://openalex.org/W1990757909","https://openalex.org/W1997469925","https://openalex.org/W1999839467","https://openalex.org/W2014651656","https://openalex.org/W2016693266","https://openalex.org/W2018255535","https://openalex.org/W2036571146","https://openalex.org/W2045361130","https://openalex.org/W2045934824","https://openalex.org/W2049043712","https://openalex.org/W2070985748","https://openalex.org/W2079433581","https://openalex.org/W2087811918","https://openalex.org/W2088424142","https://openalex.org/W2089433310","https://openalex.org/W2089688759","https://openalex.org/W2126332265","https://openalex.org/W2135905960","https://openalex.org/W2165227755","https://openalex.org/W2321744919"],"related_works":["https://openalex.org/W1997469925","https://openalex.org/W1429171507","https://openalex.org/W2020647507","https://openalex.org/W7098243576","https://openalex.org/W2017267041","https://openalex.org/W1863057369","https://openalex.org/W150251983","https://openalex.org/W2400033136","https://openalex.org/W2418010650","https://openalex.org/W2080360085"],"abstract_inverted_index":{"The":[0],"epithelia":[1],"are":[2,74],"remarkably":[3],"diverse":[4],"with":[5],"respect":[6],"to":[7,87,115],"cell":[8,38,97,129],"morphology,":[9],"tissue":[10],"structure,":[11],"and":[12,30,53,101,140,143,171],"modes":[13],"of":[14,21,25,36,47,55,66,71,78,84,89,108],"growth":[15,27,52],"regulation,":[16],"befitting":[17],"the":[18,26,48,62,67,123,137,145],"wide":[19],"range":[20],"functions":[22],"they":[23],"perform.Identification":[24],"factors,":[28],"hormones,":[29],"nutritional":[31],"components":[32],"that":[33,61],"a":[34,75,105,168,172],"variety":[35],"epithelial":[37,68,96,128],"types":[39],"require":[40],"for":[41],"serial":[42],"cultivation":[43],"is":[44,58,92],"permitting":[45],"investigation":[46],"mechanisms":[49],"regulating":[50],"their":[51],"synthesis":[54],"differentiation-related":[56],"proteins.It":[57],"now":[59],"known":[60],"keratins":[63,91],"(subunit":[64],"proteins":[65],"cell-specific":[69],"type":[70,98],"intermediate":[72],"filament)":[73],"large":[76],"family":[77],"about":[79],"20":[80],"different":[81,155],"proteins.A":[82],"subset":[83],"from":[85,132,156],"two":[86],"ten":[88],"these":[90,149],"expressed":[93],"by":[94],"each":[95],"in":[99,102,159],"vivo":[100],"culture'-'":[103],"as":[104],"stable":[106],"feature":[107],"its":[109],"differentiated":[110],"state,":[111],"although":[112],"often":[113],"subject":[114],"extrinsic":[116],"modulation?-]*Recently":[117],"this":[118],"laboratory":[119],"has":[120,167],"been":[121],"studying":[122],"mesothelial":[124],"cell-a":[125],"simple":[126],"squamous":[127],"type,":[130],"derived":[131],"embryonic":[133],"mesoderm":[134],"-that":[135],"lines":[136],"pleural,":[138],"pericardial,":[139],"peritoneal":[141],"cavities":[142],"covers":[144],"organs":[146],"contained":[147],"within":[148],"cavities.Mesothelial":[150],"cells":[151,161],"contain":[152],"four":[153],"keratins,":[154],"those":[157],"present":[158],"epidermal":[160],"(FIGURE":[162],"1).6In":[163],"vivu,":[164],"normal":[165],"mesothelium":[166],"high":[169],"keratin":[170],"low,":[173],"but":[174],"detectable,":[175],"259":[176]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
