{"id":"https://openalex.org/W2072393575","doi":"https://doi.org/10.1111/j.1600-0625.2008.00832.x","title":"Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll\u2010like receptor 2","display_name":"Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll\u2010like receptor 2","publication_year":2008,"publication_date":"2008-12-24","ids":{"openalex":"https://openalex.org/W2072393575","doi":"https://doi.org/10.1111/j.1600-0625.2008.00832.x","mag":"2072393575","pmid":"https://pubmed.ncbi.nlm.nih.gov/19196344"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0625.2008.00832.x","doi":"https://doi.org/10.1111/j.1600-0625.2008.00832.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0625.2008.00832.x","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Min Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210111590","display_name":"Chinese Academy of Medical Sciences Dermatology Hospital","ror":"https://ror.org/01z6cw088","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111590"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Min Li","raw_affiliation_strings":["Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, 12 Jiangwangmiao St., Nanjing 210042, China. minli08@gmail.com","Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China","These two authors contributed equally to this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, 12 Jiangwangmiao St., Nanjing 210042, China. minli08@gmail.com","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210111590"]},{"raw_affiliation_string":"Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"These two authors contributed equally to this study","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119532430","display_name":"Qing Chen","orcid":"https://orcid.org/0000-0002-8450-9300","observed_orcids":["https://orcid.org/0000-0002-8450-9300"]},"institutions":[{"id":"https://openalex.org/I4210130818","display_name":"Children's Hospital of Michigan","ror":"https://ror.org/0429x9p85","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800326109","https://openalex.org/I4210130818"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Chen","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Children\u2019s Hospital of Michigan, Detroit, MI, USA","These two authors contributed equally to this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Children\u2019s Hospital of Michigan, Detroit, MI, USA","institution_ids":["https://openalex.org/I4210130818"]},{"raw_affiliation_string":"These two authors contributed equally to this study","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101096669","display_name":"Yongnian Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongnian Shen","raw_affiliation_strings":["Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101595237","display_name":"Weida Liu","orcid":"https://orcid.org/0000-0003-1936-3736","observed_orcids":["https://orcid.org/0000-0003-1936-3736","https://orcid.org/0000-0001-9524-0426","https://orcid.org/0000-0002-7133-3780"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weida Liu","raw_affiliation_strings":["Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing, China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210111590"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":1.4727,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.8077062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"7","first_page":"603","last_page":"610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11253","display_name":"Nail Diseases and Treatments","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cutaneous-candidiasis","display_name":"cutaneous candidiasis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8019999861717224},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8930000066757202},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pathogen-associated-molecular-patterns","display_name":"pathogen-associated molecular patterns","score":0.8539999723434448},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.7881191968917847},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.672626793384552},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6492663621902466},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6438000202178955},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5385061502456665},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5307170152664185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5290046334266663},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4972842037677765},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.49042126536369324},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.4143711030483246},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4032554030418396},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.38293617963790894},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3744674324989319},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3230699300765991},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.28682172298431396},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2390628159046173},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0884924829006195}],"mesh":[{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002179","descriptor_name":"Candidiasis, Cutaneous","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006017","descriptor_name":"Glycolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006017","descriptor_name":"Glycolipids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0625.2008.00832.x","doi":"https://doi.org/10.1111/j.1600-0625.2008.00832.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0625.2008.00832.x","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:19196344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19196344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1519886765","https://openalex.org/W1550742290","https://openalex.org/W1627009127","https://openalex.org/W1832511462","https://openalex.org/W1948268265","https://openalex.org/W1965368723","https://openalex.org/W1965591217","https://openalex.org/W1965897811","https://openalex.org/W1978676714","https://openalex.org/W1995744610","https://openalex.org/W2017717232","https://openalex.org/W2017975787","https://openalex.org/W2023306690","https://openalex.org/W2026269930","https://openalex.org/W2028325150","https://openalex.org/W2031242426","https://openalex.org/W2036767516","https://openalex.org/W2047774467","https://openalex.org/W2063818626","https://openalex.org/W2076465259","https://openalex.org/W2079260693","https://openalex.org/W2081756009","https://openalex.org/W2082821194","https://openalex.org/W2089701444","https://openalex.org/W2100585044","https://openalex.org/W2106469311","https://openalex.org/W2107075312","https://openalex.org/W2107277218","https://openalex.org/W2110575428","https://openalex.org/W2111170139","https://openalex.org/W2114637517","https://openalex.org/W2114920135","https://openalex.org/W2118526748","https://openalex.org/W2129715917","https://openalex.org/W2145564764","https://openalex.org/W2147208502","https://openalex.org/W2151646233","https://openalex.org/W2169040326","https://openalex.org/W2171155970","https://openalex.org/W2171861423","https://openalex.org/W2172221157","https://openalex.org/W2290936009","https://openalex.org/W2411386918"],"related_works":["https://openalex.org/W2442483364","https://openalex.org/W2100585044","https://openalex.org/W2384112602","https://openalex.org/W1973650836","https://openalex.org/W2411386918","https://openalex.org/W2897271652","https://openalex.org/W2007318547","https://openalex.org/W2781353107","https://openalex.org/W2362065647","https://openalex.org/W2058553519"],"abstract_inverted_index":{"The":[0],"Toll-like":[1],"receptors":[2],"(TLRs)":[3],"play":[4],"an":[5,58],"important":[6],"role":[7],"in":[8,61,132,158,166,191],"the":[9,27,40,67,80,111,119,133,152,185,192],"recognition":[10],"of":[11,17,29,39,71,86,105,116,122,135,155,188],"Candida":[12],"albicans":[13,31],"components":[14],"and":[15,64,84,90,103,107,113,137,148,171,194],"activation":[16,134],"innate":[18],"immunity.":[19],"Phospholipomannan":[20],"(PLM),":[21],"a":[22,37],"glycolipid,":[23],"is":[24],"expressed":[25],"at":[26],"surface":[28],"C.":[30,53,179],"cell":[32],"wall,":[33],"which":[34],"acts":[35],"as":[36],"member":[38],"pathogen-associated":[41],"molecular":[42],"patterns":[43],"family.":[44],"In":[45],"this":[46],"study,":[47],"we":[48],"sought":[49],"to":[50,65,76,79,99,184],"clarify":[51],"whether":[52],"albicans-native":[54,180],"PLM":[55,77,93,109,130,181],"could":[56],"induce":[57,100],"inflammation":[59],"response":[60],"human":[62,73],"keratinocytes":[63,75],"determine":[66],"underlying":[68],"mechanisms.":[69],"Exposure":[70],"cultured":[72],"primary":[74],"led":[78],"increased":[81],"gene":[82,101],"expression":[83,102],"secretion":[85,104,154],"proinflammatory":[87],"cytokines":[88],"(IL-6)":[89],"chemokines":[91],"(IL-8).":[92],"hydrolysed":[94],"with":[95,129,168],"beta-d-mannoside":[96],"mannohydrolase":[97],"failed":[98],"IL-6":[106],"IL-8.":[108],"up-regulated":[110],"mRNA":[112,120],"protein":[114,139],"levels":[115],"TLR2,":[117],"whereas":[118],"level":[121],"TLR4":[123],"was":[124,164],"not":[125],"altered.":[126],"Keratinocytes":[127],"challenged":[128],"resulted":[131],"NF-kappaB":[136],"mitogen-activated":[138],"kinase":[140],"(MAPKs)":[141],"including":[142],"p38.":[143],"Anti-TLR2":[144],"neutralizing":[145],"antibody,":[146],"NFkappaB":[147],"p38MAPK":[149,195],"inhibitors":[150],"blocked":[151],"PLM-induced":[153],"IL-6,":[156],"IL-8":[157],"keratinocytes,":[159],"but":[160],"no":[161],"such":[162],"effect":[163],"observed":[165],"pretreatment":[167],"anti-TLR4-neutralizing":[169],"antibody":[170],"lipopolysaccharide":[172],"inhibitor":[173],"(polymyxin":[174],"B).":[175],"These":[176],"data":[177],"suggest":[178],"may":[182],"contribute":[183],"inflammatory":[186],"responses":[187],"cutaneous":[189],"candidiasis":[190],"TLR2-NF-kappaB":[193],"signalling":[196],"pathway":[197],"dependent":[198],"manner.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}