{"id":"https://openalex.org/W2072378488","doi":"https://doi.org/10.1111/j.1399-3089.2010.00573_6.x","title":"Hemeoxygenase\u20101: a cytoprotective gene with broad therapeutic potential in xenotransplantation and other inflammatory diseases","display_name":"Hemeoxygenase\u20101: a cytoprotective gene with broad therapeutic potential in xenotransplantation and other inflammatory diseases","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W2072378488","doi":"https://doi.org/10.1111/j.1399-3089.2010.00573_6.x","mag":"2072378488"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-3089.2010.00573_6.x","doi":"https://doi.org/10.1111/j.1399-3089.2010.00573_6.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3089.2010.00573_6.x","pdf_url":null,"source":{"id":"https://openalex.org/S102890116","display_name":"Xenotransplantation","issn_l":"0908-665X","issn":["0908-665X","1399-3089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenotransplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067643807","display_name":"Miguel Parreira Soares","orcid":"https://orcid.org/0000-0002-9314-4833","observed_orcids":["https://orcid.org/0000-0002-9314-4833"]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"M. Soares","raw_affiliation_strings":["Instituto Gulbenkian de Cie\u0302ncia, Oeiras, Portugal","Instituto Gulbenkian de Ci\u00eancia; Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Cie\u0302ncia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia; Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067643807"],"corresponding_institution_ids":["https://openalex.org/I48057805"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1309537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"2","first_page":"101","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.6470000147819519},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8939999938011169},{"id":"https://openalex.org/keywords/heme-degradation","display_name":"heme degradation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/biliverdin","display_name":"biliverdin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.6990000009536743},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.6949999928474426},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.746999979019165},{"id":"https://openalex.org/keywords/stress-responsive-genes","display_name":"stress response genes","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2780967304","wikidata":"https://www.wikidata.org/wiki/Q246156","display_name":"Cytoprotection","level":3,"score":0.8553388118743896},{"id":"https://openalex.org/C2778442404","wikidata":"https://www.wikidata.org/wiki/Q55505","display_name":"Xenotransplantation","level":3,"score":0.7904649376869202},{"id":"https://openalex.org/C2779730776","wikidata":"https://www.wikidata.org/wiki/Q5631153","display_name":"HMOX1","level":5,"score":0.6631648540496826},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5999265313148499},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5951798558235168},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.5067489743232727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4915657937526703},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4447143077850342},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4289102554321289},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.397458016872406},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.36945727467536926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27547961473464966},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1261865496635437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12051329016685486},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11722084879875183},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/j.1399-3089.2010.00573_6.x","doi":"https://doi.org/10.1111/j.1399-3089.2010.00573_6.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3089.2010.00573_6.x","pdf_url":null,"source":{"id":"https://openalex.org/S102890116","display_name":"Xenotransplantation","issn_l":"0908-665X","issn":["0908-665X","1399-3089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenotransplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1568253208","https://openalex.org/W2018229946","https://openalex.org/W1990834361","https://openalex.org/W2007477049","https://openalex.org/W2119001528","https://openalex.org/W1853939159","https://openalex.org/W47125266","https://openalex.org/W2044916014","https://openalex.org/W2352465368","https://openalex.org/W3171042656"],"abstract_inverted_index":{"Cells":[0],"have":[1,67,106,176],"a":[2,36,60,68,97,125,169],"variety":[3],"of":[4,28,57,73,81,91,145,183,206,213,218,227,237],"constitutive":[5],"and":[6,55,63,85,104,154,192],"inducible":[7],"defense":[8,32],"cytoprotective":[9],"mechanisms":[10,33],"against":[11],"oxidative":[12,22],"stress.":[13],"These":[14],"aim":[15],"at":[16,44],"re\u2010establishing":[17],"homeostasis":[18],"in":[19,35,71,96,123,133,142,168,172,233],"response":[20,95],"to":[21,39,109,161,208,223],"injury.":[23],"In":[24,186],"the":[25,82,89,92,112,119,134,139,143,163,173,181,204,210,225,234],"particular":[26,235],"context":[27,236],"organ":[29,62,84],"(xeno)transplantation,":[30,128],"these":[31],"contribute":[34],"critical":[37],"manner":[38,98],"sustain":[40],"(xeno)graft":[41,75,101,170],"survival":[42,54,226],"via":[43],"least":[45],"two":[46],"interrelated":[47],"mechanisms.":[48],"First,":[49],"cytoprotection":[50,78],"per":[51],"se":[52],"supports":[53],"function":[56],"cells":[58],"within":[59],"(xeno)transplanted":[61,83],"as":[64,138],"such":[65,124],"should":[66,87],"beneficial":[69],"effect":[70,199],"terms":[72],"sustaining":[74],"survival.":[76,102],"Second,":[77],"reduces":[79],"immunogenicity":[80],"thus":[86],"modulate":[88],"activation":[90],"recipient's":[93],"immune":[94],"that":[99,111,165,179,184,196],"sustains":[100],"Others":[103],"we":[105],"gathered":[107],"evidence,":[108],"suggest":[110],"stress\u2010responsive":[113],"enzyme":[114,141],"hemeoxygenase\u20101":[115],"(HO\u20101":[116],"encoded":[117],"by":[118,203],"gene":[120],"Hmox1)":[121],"acts":[122],"manner.":[126],"Upon":[127],"HO\u20101":[129,166,207],"becomes":[130],"ubiquitously":[131],"expressed":[132],"transplanted":[135,228],"organ,":[136],"acting":[137],"rate\u2010limiting":[140],"catabolism":[144],"free":[146,214],"heme":[147],"into":[148],"carbon":[149],"monoxide":[150],"(CO),":[151],"iron":[152],"(Fe)":[153],"biliverdin.":[155],"There":[156],"is":[157],"now":[158],"accumulating":[159],"evidence":[160,195],"support":[162,224],"notion":[164],"expression":[167],"and/or":[171],"recipient":[174],"can":[175],"salutary":[177,198],"effects":[178,212],"prevent":[180],"rejection":[182],"(xeno)graft.":[185],"this":[187,197,220],"talk":[188],"I":[189],"will":[190,230],"argue":[191],"provide":[193],"experimental":[194],"might":[200],"be":[201,231],"mediated":[202],"ability":[205],"limit":[209],"deleterious":[211],"heme.":[215],"The":[216],"possibility":[217],"using":[219],"\u201cprotective":[221],"effect\u201d":[222],"organs":[229],"addressed":[232],"xenotransplantation.":[238]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
