{"id":"https://openalex.org/W2072376684","doi":"https://doi.org/10.1016/j.diff.2010.08.005","title":"Enhanced hepatic differentiation of mesenchymal stem cells after pretreatment with injured liver tissue","display_name":"Enhanced hepatic differentiation of mesenchymal stem cells after pretreatment with injured liver tissue","publication_year":2010,"publication_date":"2010-10-13","ids":{"openalex":"https://openalex.org/W2072376684","doi":"https://doi.org/10.1016/j.diff.2010.08.005","mag":"2072376684","pmid":"https://pubmed.ncbi.nlm.nih.gov/20943307"},"language":"en","primary_location":{"id":"doi:10.1016/j.diff.2010.08.005","doi":"https://doi.org/10.1016/j.diff.2010.08.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.diff.2010.08.005","pdf_url":null,"source":{"id":"https://openalex.org/S53475899","display_name":"Differentiation","issn_l":"0301-4681","issn":["0301-4681","1432-0436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Differentiation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017026968","display_name":"Sadia Mohsin","orcid":"https://orcid.org/0000-0002-2106-1094","observed_orcids":["https://orcid.org/0000-0002-2106-1094"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sadia Mohsin","raw_affiliation_strings":["National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003037848","display_name":"Sulaiman Shams","orcid":"https://orcid.org/0000-0001-7792-1180","observed_orcids":["https://orcid.org/0000-0001-7792-1180"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sulaiman Shams","raw_affiliation_strings":["National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066200728","display_name":"Ghazanfar Ali Nasir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ghazanfar Ali Nasir","raw_affiliation_strings":["National Center of Excellence in Molecular Biology, 87 West Canal Bank Road, University of the Punjab, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Excellence in Molecular Biology, 87 West Canal Bank Road, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053928033","display_name":"Mohsin Khan","orcid":"https://orcid.org/0000-0001-7007-1048","observed_orcids":["https://orcid.org/0000-0001-7007-1048"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mohsin Khan","raw_affiliation_strings":["National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013672537","display_name":"Sana Javaid Awan","orcid":"https://orcid.org/0000-0001-5333-6702","observed_orcids":["https://orcid.org/0000-0001-5333-6702"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sana Javaid Awan","raw_affiliation_strings":["National Center of Excellence in Molecular Biology, 87 West Canal Bank Road, University of the Punjab, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Excellence in Molecular Biology, 87 West Canal Bank Road, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108227268","display_name":"Shaheen N. Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shaheen N. Khan","raw_affiliation_strings":["National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056512930","display_name":"Sheikh Amer Riazuddin","orcid":"https://orcid.org/0000-0001-6012-0192","observed_orcids":["https://orcid.org/0000-0001-6012-0192"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Sheikh Riazuddin","raw_affiliation_strings":["National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Excellence in Molecular Biology, 87-West Canal Bank Road, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056512930"],"corresponding_institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":2.2776,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.87319983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"81","issue":"1","first_page":"42","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatic-differentiation","display_name":"hepatic differentiation","score":0.984000027179718},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.6240000128746033},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cell-homing","display_name":"cell homing","score":0.5910000205039978},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hepatocyte-markers","display_name":"hepatocyte markers","score":0.5389999747276306},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4659999907016754},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8017492890357971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6402245163917542},{"id":"https://openalex.org/C116716535","wikidata":"https://www.wikidata.org/wiki/Q5009851","display_name":"CD90","level":4,"score":0.6150946021080017},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5080287456512451},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.48559969663619995},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4637245535850525},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42952588200569153},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.42424240708351135},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4205928444862366},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.407576322555542},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.2518513798713684},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.225791335105896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14948773384094238},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14849001169204712},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08067566156387329},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015696","descriptor_name":"Gene Products, tat","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051538","descriptor_name":"Hepatocyte Nuclear Factor 1-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.diff.2010.08.005","doi":"https://doi.org/10.1016/j.diff.2010.08.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.diff.2010.08.005","pdf_url":null,"source":{"id":"https://openalex.org/S53475899","display_name":"Differentiation","issn_l":"0301-4681","issn":["0301-4681","1432-0436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Differentiation","raw_type":"journal-article"},{"id":"pmid:20943307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20943307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Differentiation; research in biological diversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W68928600","https://openalex.org/W122380073","https://openalex.org/W1909955930","https://openalex.org/W1978514461","https://openalex.org/W1980325398","https://openalex.org/W1996623301","https://openalex.org/W2003612554","https://openalex.org/W2003994441","https://openalex.org/W2007658961","https://openalex.org/W2022035441","https://openalex.org/W2022884442","https://openalex.org/W2025866203","https://openalex.org/W2030771547","https://openalex.org/W2036450544","https://openalex.org/W2051922866","https://openalex.org/W2053092860","https://openalex.org/W2053576798","https://openalex.org/W2053714569","https://openalex.org/W2056850633","https://openalex.org/W2057055394","https://openalex.org/W2064252292","https://openalex.org/W2071730233","https://openalex.org/W2072176858","https://openalex.org/W2072390562","https://openalex.org/W2074000348","https://openalex.org/W2074246682","https://openalex.org/W2075348465","https://openalex.org/W2081321708","https://openalex.org/W2094432949","https://openalex.org/W2098348380","https://openalex.org/W2105649511","https://openalex.org/W2107259575","https://openalex.org/W2109191124","https://openalex.org/W2115335074","https://openalex.org/W2116582289","https://openalex.org/W2126892264","https://openalex.org/W2128825156","https://openalex.org/W2158048826","https://openalex.org/W2161820725","https://openalex.org/W2171383148","https://openalex.org/W2381786617","https://openalex.org/W2384122820","https://openalex.org/W2983266270","https://openalex.org/W4214819463","https://openalex.org/W4232584760","https://openalex.org/W6809112960"],"related_works":["https://openalex.org/W2988580977","https://openalex.org/W2351437132","https://openalex.org/W2075364726","https://openalex.org/W2079256869","https://openalex.org/W4415721989","https://openalex.org/W7096648948","https://openalex.org/W7098913763","https://openalex.org/W2398950475","https://openalex.org/W2466150620","https://openalex.org/W1682217338"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}