{"id":"https://openalex.org/W2072371083","doi":"https://doi.org/10.1159/000053259","title":"Significant Gene Expression of Insulin-Like Growth Factor II and Proliferating Cell Nuclear Antigen in a Rapidly Growing Recurrent Pituitary ACTH-Secreting Adenoma","display_name":"Significant Gene Expression of Insulin-Like Growth Factor II and Proliferating Cell Nuclear Antigen in a Rapidly Growing Recurrent Pituitary ACTH-Secreting Adenoma","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2072371083","doi":"https://doi.org/10.1159/000053259","mag":"2072371083","pmid":"https://pubmed.ncbi.nlm.nih.gov/11416238"},"language":"en","primary_location":{"id":"doi:10.1159/000053259","doi":"https://doi.org/10.1159/000053259","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000053259","pdf_url":null,"source":{"id":"https://openalex.org/S159506102","display_name":"Hormone Research in Paediatrics","issn_l":"1663-2818","issn":["1663-2818","1663-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone Research in Paediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109070741","display_name":"Kozo Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kozo Hashimoto","raw_affiliation_strings":["2nd Department of Internal Medicine, Kochi Medical School, Nankoku, Japan. hasimotk@kochi-ms.ac.jp","2nd Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Internal Medicine, Kochi Medical School, Nankoku, Japan. hasimotk@kochi-ms.ac.jp","institution_ids":["https://openalex.org/I4210088960"]},{"raw_affiliation_string":"2nd Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Isao Nagano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isao Nagano","raw_affiliation_strings":["2nd Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111939075","display_name":"Koichi Asaba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koichi Asaba","raw_affiliation_strings":["2nd Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103782813","display_name":"Mari Inoue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mari Inoue","raw_affiliation_strings":["2nd Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113601460","display_name":"Tatsuya Nishioka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuya Nishioka","raw_affiliation_strings":["2nd Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045586814","display_name":"Toshihiro Takao","orcid":"https://orcid.org/0000-0002-4252-3438","observed_orcids":["https://orcid.org/0000-0002-4252-3438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshihiro Takao","raw_affiliation_strings":["2nd Department of Internal Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Internal Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103906316","display_name":"Takahito Nakajo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahito Nakajo","raw_affiliation_strings":["Department of Neurosurgery, Kochi Medical School, Nankoku, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Kochi Medical School, Nankoku, and","institution_ids":["https://openalex.org/I4210088960"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takahisa Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahisa Mori","raw_affiliation_strings":["Department of Neurosurgery, Kochi Medical School, Nankoku, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Kochi Medical School, Nankoku, and","institution_ids":["https://openalex.org/I4210088960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035449306","display_name":"Masahiro Kurisaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Kurisaka","raw_affiliation_strings":["Department of Neurosurgery, Kochi Medical School, Nankoku, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Kochi Medical School, Nankoku, and","institution_ids":["https://openalex.org/I4210088960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041765648","display_name":"Fumio Otsuka","orcid":"https://orcid.org/0000-0001-7014-9095","observed_orcids":["https://orcid.org/0000-0001-7014-9095"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumio Otsuka","raw_affiliation_strings":["3rd Department of Internal Medicine, Okayama University Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Internal Medicine, Okayama University Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2623,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.79460937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"54","issue":"4","first_page":"198","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cushing-disease","display_name":"Cushing's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/recurrent-pituitary-adenoma","display_name":"recurrent pituitary adenoma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.8999999761581421},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/abducens-nerve-palsy","display_name":"abducens nerve palsy","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7206521034240723},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7203392386436462},{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.6195265650749207},{"id":"https://openalex.org/C79381400","wikidata":"https://www.wikidata.org/wiki/Q5173293","display_name":"Corticotropic cell","level":4,"score":0.6084316372871399},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.5804084539413452},{"id":"https://openalex.org/C2781309135","wikidata":"https://www.wikidata.org/wiki/Q418896","display_name":"Proopiomelanocortin","level":3,"score":0.5638580918312073},{"id":"https://openalex.org/C2776810848","wikidata":"https://www.wikidata.org/wiki/Q1947304","display_name":"Cushing's disease","level":3,"score":0.5443429946899414},{"id":"https://openalex.org/C2778491484","wikidata":"https://www.wikidata.org/wiki/Q922411","display_name":"Hypopituitarism","level":2,"score":0.5431252717971802},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.45660948753356934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4456270635128021},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.42676061391830444},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.34691351652145386},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.30655747652053833},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000053259","doi":"https://doi.org/10.1159/000053259","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000053259","pdf_url":null,"source":{"id":"https://openalex.org/S159506102","display_name":"Hormone Research in Paediatrics","issn_l":"1663-2818","issn":["1663-2818","1663-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone Research in Paediatrics","raw_type":"journal-article"},{"id":"pmid:11416238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11416238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone research","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W99842511","https://openalex.org/W1955141690","https://openalex.org/W1963747253","https://openalex.org/W1990307054","https://openalex.org/W1995983939","https://openalex.org/W2005427302","https://openalex.org/W2010788874","https://openalex.org/W2011722112","https://openalex.org/W2025056130","https://openalex.org/W2046106422","https://openalex.org/W2065437604","https://openalex.org/W2094303934","https://openalex.org/W2115679080","https://openalex.org/W2130858725","https://openalex.org/W2138070751","https://openalex.org/W2186745027","https://openalex.org/W3013482651","https://openalex.org/W4238687097","https://openalex.org/W4248807629"],"related_works":["https://openalex.org/W2075771255","https://openalex.org/W2001214726","https://openalex.org/W2059796564","https://openalex.org/W2037708497","https://openalex.org/W2019735663","https://openalex.org/W2089033050","https://openalex.org/W2154357554","https://openalex.org/W1986253284","https://openalex.org/W4387379101","https://openalex.org/W2027650565"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"quantified":[2],"the":[3,56,71,96,127,138,194,198,210,214,243,260],"expression":[4,199,219],"of":[5,49,73,89,95,113,122,200,213,220,265],"various":[6],"growth-related":[7,201],"factors":[8,202,255],"in":[9,209,242,259],"an":[10,99],"adrenocorticotropic":[11],"hormone":[12,81],"(ACTH)-secreting":[13],"adenoma":[14,244],"that":[15,126],"had":[16],"recurred":[17],"very":[18,51],"rapidly":[19],"as":[20],"invasive":[21],"macroadenoma.":[22],"METHODS/RESULTS:":[23],"A":[24,217,233],"43-year-old":[25],"woman":[26],"underwent":[27],"successful":[28],"transsphenoidal":[29],"surgery":[30],"for":[31,43],"Cushing's":[32,90],"disease.":[33,91],"Seven":[34],"years":[35,136],"later,":[36,137],"she":[37],"was":[38,60,106,149,191,231,239],"admitted":[39],"to":[40],"our":[41],"ward":[42],"further":[44],"endocrine":[45],"examinations.":[46],"In":[47],"spite":[48],"a":[50,179],"high":[52,234,247],"plasma":[53,156],"ACTH":[54,64,157,170],"level,":[55],"serum":[57,159],"cortisol":[58,66,163,172],"level":[59],"normal.":[61],"Discrepancies":[62],"between":[63,169],"and":[65,79,103,118,143,152,158,160,171,185,193,197,225,253,263],"levels":[67,164],"were":[68,165,203,207],"detected":[69,241],"on":[70],"basis":[72],"diurnal":[74],"rhythms,":[75],"dexamethasone":[76],"suppression":[77],"tests,":[78],"corticotropin-releasing":[80],"test.":[82],"The":[83,189],"patient":[84,139],"showed":[85,98],"no":[86,104],"clinical":[87],"features":[88],"Magnetic":[92,175],"resonance":[93,176],"imaging":[94,177],"pituitary":[97,181,268],"almost":[100],"empty":[101],"sella,":[102],"microadenoma":[105],"found.":[107],"These":[108,251],"results,":[109],"along":[110],"with":[111,183],"those":[112],"Sephadex":[114],"column":[115],"gel":[116],"filtration":[117],"high-performance":[119],"liquid":[120],"chromatography":[121],"plasma-immunoreactive":[123],"ACTH,":[124],"suggested":[125],"patient's":[128,267],"residual":[129],"corticotrophs":[130],"secreted":[131],"biologically":[132],"inactive":[133],"ACTH.":[134],"Two":[135],"suddenly":[140],"developed":[141],"diplopia":[142],"right":[144],"abducens":[145],"nerve":[146],"palsy.":[147],"She":[148],"slightly":[150],"moonfaced":[151],"centrally":[153],"obese.":[154],"Her":[155],"urinary":[161],"free":[162],"elevated,":[166],"although":[167],"discrepancies":[168],"still":[173],"existed.":[174],"revealed":[178],"large":[180],"mass":[182],"suprasellar":[184],"cavernous":[186],"sinus":[187],"extensions.":[188],"tumor":[190],"excised,":[192],"proopiomelanocortin":[195,215],"gene":[196],"analyzed.":[204],"No":[205],"mutations":[206],"found":[208],"ACTH-coding":[211],"region":[212],"gene.":[216],"significant":[218],"insulin-like":[221],"growth":[222,262],"factor":[223],"II":[224],"proliferating":[226],"cell":[227],"nuclear":[228],"antigen":[229],"mRNAs":[230],"demonstrated.":[232],"MIB-1":[235],"antibody":[236],"labeling":[237],"index":[238],"also":[240],"tissue,":[245],"suggesting":[246],"Ki-67":[248],"expression.":[249],"CONCLUSION:":[250],"growth-":[252],"proliferation-related":[254],"might":[256],"be":[257],"involved":[258],"rapid":[261],"aggressiveness":[264],"this":[266],"adenoma.":[269]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}