{"id":"https://openalex.org/W2072348418","doi":"https://doi.org/10.1002/hep.25776","title":"Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells","display_name":"Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells","publication_year":2012,"publication_date":"2012-04-13","ids":{"openalex":"https://openalex.org/W2072348418","doi":"https://doi.org/10.1002/hep.25776","mag":"2072348418","pmid":"https://pubmed.ncbi.nlm.nih.gov/22505225","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418440"},"language":"en","primary_location":{"id":"doi:10.1002/hep.25776","doi":"https://doi.org/10.1002/hep.25776","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25776","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25776","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25776","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017426783","display_name":"Edward Kai\u2010Hua Chow","orcid":"https://orcid.org/0000-0002-3075-1898","observed_orcids":["https://orcid.org/0000-0002-3075-1898"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward Kai-Hua Chow","raw_affiliation_strings":["Department of Microbiology and Immunology, G. W. Hooper Research Foundation, University of California, San Francisco, CA 94143, USA. edward.chow@ucsf.edu","Department of Microbiology and Immunology, G. W. Hooper Research Foundation, University of California, San Francisco, CA","fax: 415-476-6185"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, G. W. Hooper Research Foundation, University of California, San Francisco, CA 94143, USA. edward.chow@ucsf.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, G. W. Hooper Research Foundation, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"fax: 415-476-6185","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101548097","display_name":"Lingling Fan","orcid":"https://orcid.org/0000-0002-2666-1582","observed_orcids":["https://orcid.org/0000-0002-2666-1582"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ling-ling Fan","raw_affiliation_strings":["Center for Stem Cell Research and Application, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell Research and Application, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363101","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-9588-0164","observed_orcids":["https://orcid.org/0000-0002-9588-0164"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":null,"display_name":"Michael J. Bishop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Bishop","raw_affiliation_strings":["Department of Microbiology and Immunology, G. W. Hooper Research Foundation, University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, G. W. Hooper Research Foundation, University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017426783"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":3.5979,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.94030408,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"56","issue":"4","first_page":"1331","last_page":"1341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9589999914169312},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.7440000176429749},{"id":"https://openalex.org/keywords/myc-driven-tumors","display_name":"MYC-driven tumors","score":0.7429999709129333},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6930000185966492},{"id":"https://openalex.org/keywords/nras","display_name":"NRAS","score":0.9959999918937683},{"id":"https://openalex.org/keywords/side-population","display_name":"side population cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hoechst-33342-efflux","display_name":"Hoechst 33342 efflux","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mdr1","display_name":"MDR1","score":0.6159999966621399},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.722000002861023},{"id":"https://openalex.org/keywords/hepatic-progenitor-cells","display_name":"hepatic progenitor cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2780546549","wikidata":"https://www.wikidata.org/wiki/Q7508338","display_name":"Side population","level":4,"score":0.7622140645980835},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7480121850967407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6888843178749084},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6655557751655579},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5405174493789673},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5379688143730164},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5002365112304688},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.49494022130966187},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4906724691390991},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.45590701699256897},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.44956374168395996},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3352310061454773},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2516099810600281},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.17470794916152954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1302376687526703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08712169528007507},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08382934331893921},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/hep.25776","doi":"https://doi.org/10.1002/hep.25776","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25776","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25776","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:22505225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22505225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2774435","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418440","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3418440","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418440","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hepatology","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8c98h94r","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8c98h94r","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hepatology, vol 56, iss 4","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/hep.25776","doi":"https://doi.org/10.1002/hep.25776","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.25776","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25776","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8785859341","display_name":"Molecular Genetics of Liver Cancers","funder_award_id":"R01CA136606","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072348418.pdf","grobid_xml":"https://content.openalex.org/works/W2072348418.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W43614546","https://openalex.org/W1492396077","https://openalex.org/W1499694712","https://openalex.org/W1879626379","https://openalex.org/W1970468480","https://openalex.org/W1976251743","https://openalex.org/W1983826831","https://openalex.org/W1984500423","https://openalex.org/W1985166341","https://openalex.org/W1986403359","https://openalex.org/W1986815130","https://openalex.org/W1994993863","https://openalex.org/W2001826331","https://openalex.org/W2008737258","https://openalex.org/W2017352677","https://openalex.org/W2018591615","https://openalex.org/W2019120715","https://openalex.org/W2033346155","https://openalex.org/W2035528570","https://openalex.org/W2036172570","https://openalex.org/W2039767026","https://openalex.org/W2051935450","https://openalex.org/W2054657650","https://openalex.org/W2057436316","https://openalex.org/W2064437405","https://openalex.org/W2067224679","https://openalex.org/W2071697398","https://openalex.org/W2075563306","https://openalex.org/W2083819316","https://openalex.org/W2084446191","https://openalex.org/W2087943174","https://openalex.org/W2099865291","https://openalex.org/W2105121597","https://openalex.org/W2112738731","https://openalex.org/W2123641599","https://openalex.org/W2124603900","https://openalex.org/W2130976070","https://openalex.org/W2134987819","https://openalex.org/W2137956382","https://openalex.org/W2142291307","https://openalex.org/W2148365177","https://openalex.org/W2149226545","https://openalex.org/W2150485214","https://openalex.org/W2151948621","https://openalex.org/W2152690616","https://openalex.org/W2158362968","https://openalex.org/W2161892077","https://openalex.org/W2168471377","https://openalex.org/W2388163742","https://openalex.org/W4244573269","https://openalex.org/W6684834458"],"related_works":["https://openalex.org/W1765254582","https://openalex.org/W2472838456","https://openalex.org/W2888208679","https://openalex.org/W4296836661","https://openalex.org/W2058359419","https://openalex.org/W2030764098","https://openalex.org/W2083479805","https://openalex.org/W1414004483","https://openalex.org/W195656991","https://openalex.org/W4394869614"],"abstract_inverted_index":{"UNLABELLED:":[0],"At":[1],"least":[2],"some":[3],"cancer":[4,34],"stem":[5],"cells":[6,83,101,111,133,180,187,197],"(CSCs)":[7],"display":[8],"intrinsic":[9],"drug":[10,151],"resistance":[11,27,166],"that":[12,74,84,154,163,200,218,229,249],"may":[13,256],"thwart":[14],"eradication":[15],"of":[16,25,32,42,45,47,60,66,82,105,121,142,176,208,216,224,232,246,260],"a":[17,80,209,213],"malignancy":[18],"by":[19,28,36,147,203],"chemotherapy.":[20],"We":[21,72,161],"explored":[22],"the":[23,40,67,76,126,164,174,222,239,247,258],"genesis":[24,259],"such":[26],"studying":[29],"mouse":[30,254],"models":[31,255],"liver":[33,264],"driven":[35],"either":[37],"MYC":[38],"or":[39],"combination":[41],"oncogenic":[43],"forms":[44],"activation":[46],"v-akt":[48],"murine":[49],"thymoma":[50],"viral":[51],"oncogene":[52],"homolog":[53],"(AKT)":[54],"and":[55,102,125,188],"NRAS.":[56],"A":[57],"common":[58],"manifestation":[59],"chemoresistance":[61,158,217,240,251,261],"in":[62,159,181,252,262],"CSCs":[63,95,233],"is":[64,145],"efflux":[65,85,175],"DNA-binding":[68],"dye":[69],"Hoechst":[70,86,143,177],"33342.":[71,87],"found":[73,162],"only":[75],"MYC-driven":[77,183],"tumors":[78],"contained":[79],"subset":[81,191],"This":[88],"\"side":[89],"population\"":[90],"(SP)":[91],"was":[92,171],"enriched":[93],"for":[94,128,173],"when":[96],"compared":[97],"to":[98,138,157,198,221],"non-SP":[99,115,132,196],"tumor":[100,116,210,237],"exhibited":[103],"markers":[104],"hepatic":[106,225],"progenitor":[107,123],"cells.":[108,140],"The":[109,206],"SP":[110,139,179,186],"could":[112],"differentiate":[113],"into":[114,234],"cells,":[117,238],"with":[118],"coordinate":[119],"loss":[120],"chemoresistance,":[122],"markers,":[124],"enrichment":[127],"CSCs.":[129,226],"In":[130],"contrast,":[131],"did":[134],"not":[135],"give":[136],"rise":[137],"Exclusion":[141],"33342":[144],"mediated":[146],"ATP":[148],"binding":[149],"cassette":[150],"transporter":[152,170],"proteins":[153],"also":[155],"contribute":[156,220],"cancer.":[160,265],"multidrug":[165],"gene":[167],"1":[168],"(MDR1)":[169],"responsible":[172],"from":[178],"our":[182],"model.":[184],"Accordingly,":[185],"their":[189],"tumor-initiating":[190],"were":[192],"more":[193,235],"resistant":[194],"than":[195],"chemotherapeutics":[199],"are":[201],"effluxed":[202],"MDR1.":[204],"CONCLUSION:":[205],"oncogenotype":[207],"can":[211,219,241],"promote":[212,230],"specific":[214],"mechanism":[215],"survival":[223],"Under":[227],"circumstances":[228],"differentiation":[231],"mature":[236],"be":[242],"quickly":[243],"lost.":[244],"Elucidation":[245],"mechanisms":[248],"govern":[250],"these":[253],"illuminate":[257],"human":[263]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}