{"id":"https://openalex.org/W2072247644","doi":"https://doi.org/10.1097/01.mpg.0000237931.53470.ba","title":"Arachidonic Acid Content in Adipose Tissue Is Associated With Insulin Resistance in Healthy Children","display_name":"Arachidonic Acid Content in Adipose Tissue Is Associated With Insulin Resistance in Healthy Children","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2072247644","doi":"https://doi.org/10.1097/01.mpg.0000237931.53470.ba","mag":"2072247644","pmid":"https://pubmed.ncbi.nlm.nih.gov/17204958"},"language":"en","primary_location":{"id":"doi:10.1097/01.mpg.0000237931.53470.ba","doi":"https://doi.org/10.1097/01.mpg.0000237931.53470.ba","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpg.0000237931.53470.ba","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063174554","display_name":"Luis Jose Aldamiz-Echevarria","orcid":"https://orcid.org/0000-0003-0687-6604","observed_orcids":["https://orcid.org/0000-0003-0687-6604"]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Luis Ald\u00e1miz\u2010Echevarr\u00eda","raw_affiliation_strings":["Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain","reprint requests to Dr. Luis Ald\u00e1miz-Echevarr\u00eda, Divisi\u00f3n de Metabolismo, Departamento de Pediatr\u00eda, Hospital de Cruces, 48903 Barakaldo, Spain (E-mail: [email\u00a0protected])"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain","institution_ids":["https://openalex.org/I4210137412"]},{"raw_affiliation_string":"reprint requests to Dr. Luis Ald\u00e1miz-Echevarr\u00eda, Divisi\u00f3n de Metabolismo, Departamento de Pediatr\u00eda, Hospital de Cruces, 48903 Barakaldo, Spain (E-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103494951","display_name":"Jos\u00e9 Angel Prieto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A Prieto","raw_affiliation_strings":["Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065348183","display_name":"Fernando Andrade","orcid":"https://orcid.org/0000-0003-1197-0443","observed_orcids":["https://orcid.org/0000-0003-1197-0443"]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fernando Andrade","raw_affiliation_strings":["Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022442625","display_name":"Javier Elorz","orcid":"https://orcid.org/0000-0002-8614-5109","observed_orcids":["https://orcid.org/0000-0002-8614-5109"]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Elorz","raw_affiliation_strings":["Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036645106","display_name":"Pablo Sanjurjo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Sanjurjo","raw_affiliation_strings":["Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054366704","display_name":"Juan Rodr\u00edguez Soriano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Rodr\u00edguez Soriano","raw_affiliation_strings":["Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain","institution_ids":["https://openalex.org/I4210137412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063174554"],"corresponding_institution_ids":["https://openalex.org/I4210137412"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":2.7645,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.88954889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"44","issue":"1","first_page":"77","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9700000286102295},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8759999871253967},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8659999966621399},{"id":"https://openalex.org/keywords/fatty-acid-composition","display_name":"fatty acid composition","score":0.8510000109672546},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8240000009536743},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5389999747276306},{"id":"https://openalex.org/keywords/homa-index","display_name":"HOMA index","score":0.7089999914169312},{"id":"https://openalex.org/keywords/insulin-levels","display_name":"insulin levels","score":0.8899999856948853},{"id":"https://openalex.org/keywords/linoleic-acid","display_name":"linoleic acid","score":0.7799999713897705},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":1.0},{"id":"https://openalex.org/keywords/trans-fatty-acids","display_name":"trans fatty acids","score":0.9490000009536743},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9478601217269897},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.861996054649353},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8316181898117065},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.7496803998947144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5801051259040833},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5512151718139648},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5022625923156738},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1578224003314972},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.mpg.0000237931.53470.ba","doi":"https://doi.org/10.1097/01.mpg.0000237931.53470.ba","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpg.0000237931.53470.ba","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},{"id":"pmid:17204958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17204958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric gastroenterology and nutrition","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1536281764","https://openalex.org/W1564433957","https://openalex.org/W1823183858","https://openalex.org/W1871942206","https://openalex.org/W1876046294","https://openalex.org/W1925909900","https://openalex.org/W1949305708","https://openalex.org/W1953409237","https://openalex.org/W1962574364","https://openalex.org/W1966227854","https://openalex.org/W1966296687","https://openalex.org/W1974698688","https://openalex.org/W1975672885","https://openalex.org/W1977436008","https://openalex.org/W1982460743","https://openalex.org/W1987243476","https://openalex.org/W1997187747","https://openalex.org/W2006353594","https://openalex.org/W2009389715","https://openalex.org/W2011076773","https://openalex.org/W2019675955","https://openalex.org/W2020981912","https://openalex.org/W2022584932","https://openalex.org/W2023069079","https://openalex.org/W2033211235","https://openalex.org/W2035093916","https://openalex.org/W2035586426","https://openalex.org/W2040759506","https://openalex.org/W2050372974","https://openalex.org/W2052996202","https://openalex.org/W2058762551","https://openalex.org/W2060070399","https://openalex.org/W2076918333","https://openalex.org/W2098065069","https://openalex.org/W2102966441","https://openalex.org/W2106234893","https://openalex.org/W2111544843","https://openalex.org/W2113768115","https://openalex.org/W2116824077","https://openalex.org/W2119400774","https://openalex.org/W2119859961","https://openalex.org/W2121820700","https://openalex.org/W2129316761","https://openalex.org/W2130362366","https://openalex.org/W2132028404","https://openalex.org/W2156637290","https://openalex.org/W2158418727","https://openalex.org/W2159052592","https://openalex.org/W2160234571","https://openalex.org/W2168526937","https://openalex.org/W2170381403","https://openalex.org/W2211467290","https://openalex.org/W2263011231","https://openalex.org/W2315929780","https://openalex.org/W2327794244","https://openalex.org/W2468467232"],"related_works":["https://openalex.org/W2102966441","https://openalex.org/W2070874135","https://openalex.org/W2093171656","https://openalex.org/W3168931857","https://openalex.org/W2130710838","https://openalex.org/W2953975554","https://openalex.org/W2067759859","https://openalex.org/W2166862791","https://openalex.org/W2151469610","https://openalex.org/W2061194677"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"fatty":[2,27,196],"acid":[3,28,74,120,127,148,175,224],"composition":[4,29,75],"of":[5,30,76,91,103,205,215],"membrane":[6],"structural":[7],"lipids,":[8],"which":[9,218],"is":[10,16,219],"partly":[11],"dependent":[12],"on":[13],"dietary":[14],"intake,":[15],"associated":[17],"with":[18,37,135,202,222],"insulin":[19,38,94,206,216],"action.":[20],"AIM:":[21],"To":[22],"examine":[23],"the":[24,115],"association":[25],"between":[26,141,168],"adipose":[31,77,108,130,151,227],"tissue":[32,78,109,131,152],"and":[33,67,80,87,93,106,125,146,173,187],"skeletal":[34,81,123,178],"muscle":[35,82,124,179],"phospholipids":[36,180],"resistance":[39],"markers":[40],"in":[41,122,129,150,177,226],"a":[42,48,100,212],"healthy":[43,54],"pediatric":[44,116],"population.":[45],"METHODS:":[46],"Using":[47],"cross-sectional":[49],"design,":[50],"we":[51],"studied":[52],"83":[53],"children":[55,210],"divided":[56],"into":[57],"3":[58],"groups,":[59],"ages":[60],"2":[61],"to":[62,65],"5,":[63],"6":[64],"10":[66,70],"more":[68],"than":[69],"years.":[71],"MEASUREMENTS:":[72],"Fatty":[73],"triacylglycerols":[79,153],"phospholipids,":[83],"plasma":[84,89],"lipid":[85],"profile":[86],"fasting":[88],"levels":[90],"glucose":[92],"were":[95],"measured.":[96],"RESULTS:":[97],"There":[98],"was":[99,160,166],"linear":[101],"increase":[102,214],"insulinemia,":[104],"glycemia":[105],"homeostasis":[107],"model":[110],"assessment":[111],"(HOMA)":[112],"index":[113,145,172],"throughout":[114],"age":[117],"range.":[118],"Linoleic":[119],"proportion":[121,128],"arachidonic":[126,147,223],"also":[132],"increased":[133],"significantly":[134,220],"age.":[136],"An":[137,162],"age-independent":[138],"positive":[139],"correlation":[140,165],"insulinemia":[142,169],"or":[143,170],"HOMA":[144,171],"content":[149,176,198,225],"(r":[154,181],"=":[155,182,185,189],"0.47,":[156],"P":[157,184,191],"<":[158,192],"0.001)":[159],"found.":[161],"age-dependent":[163],"negative":[164],"present":[167,211],"oleic":[174],"-0.30,":[183],"0.03":[186],"r":[188],"-0.28,":[190],"0.04,":[193],"respectively).":[194],"Trans":[195],"acids":[197],"did":[199],"not":[200],"correlate":[201],"any":[203],"marker":[204],"resistance.":[207],"CONCLUSION:":[208],"Healthy":[209],"prepubertal":[213],"resistance,":[217],"correlated":[221],"tissue.":[228]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}